Syndrome of Transient Headache and Neurological Deficits with Cerebrospinal Fluid Lymphocytosis: HaNDL

Nakashima, Kenichiro

doi:10.2169/internalmedicine.44.690

Cited by 10 publications

(5 citation statements)

References 5 publications

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“…HaNDL syndrome and its potential relationship to migraine have been evaluated in several studies. [ 12 ] Transcranial Doppler sonography and cerebral angiograms have been used to evaluate intracranial blood flow during and after episodes of HaNDL syndrome. Asymmetric velocities and pulsatilities were documented in bilateral middle cerebral arteries during an episode that normalized later simulating vasomotor features seen in migraine.…”

Section: Discussionmentioning

confidence: 99%

Recurrent headache in a five year old boy

Saini

Kumar

Chakrabarty

et al. 2016

Ann Indian Acad Neurol

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Headache is infrequent in early childhood. Headache and neurological deficits associated with cerebrospinal fluid (CSF) lymphocytosis (HaNDL), a variant of migraine, is a rare disorder. A 5-year-old boy presented with recurrent episodes of headache for 6 months. Each episode lasted for a week and in the current episode, he was symptomatic for 3 days. All the episodes were associated with paresthesias and CSF lymplocytosis with normal protein and sugar. There was history of migraine in his family. His magnetic resonance imaging (MRI) brain with contrast with magnetic resonance (MR) angiography and venography were normal. Work-up for relevant causes of infection and vasculitis were negative. His symptoms subsided on oral antimigraine prophylaxis and he has been on remission for last 8 months. HaNDL should be considered in relevant clinical scenarios, as it prevents unnecessary investigations, therapy, and hospitalization.

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Section: Discussionmentioning

confidence: 99%

Recurrent headache in a five year old boy

Saini

Kumar

Chakrabarty

et al. 2016

Ann Indian Acad Neurol

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“…Nakashima concluded that while this syndrome is likely to be benign and occur infrequently, it should be considered in the differential diagnosis when evaluating patients with headache and neurological deficits [16]. …”

Section: Discussionmentioning

confidence: 99%

Confusional State in HaNDL Syndrome: Case Report and Literature Review

Nelson

2013

Case Reports in Neurological Medicine

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The syndrome of transient headache and neurologic deficits with cerebrospinal fluid lymphocytosis (HaNDL syndrome) is a self-limited condition. Confusional states are uncommonly reported as a clinical manifestation of this syndrome. Here, I report a 76-year-old female who presented with headache, confusion, and agitation with a mild CSF lymphocytosis. Other workup to determine the cause of her altered mental status was otherwise negative. The literature available in the English language on HaNDL syndrome is reviewed, including its history, pathophysiology, possible associations with migraine and stroke, and previously reported cases of confusional states in this syndrome. While HaNDL syndrome has been a described entity since the 1980s, its pathophysiology has yet to be clearly defined.

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“…En períodos asintomáticos es normal. (9,12,14) La tomograf ía computarizada de emisión monofotónica: Hipoperfusión cerebral focal transitoria en regiones congruentes con la clínica.…”

Section: Estudios Funcionalesunclassified

Síndrome de HaNDL: cefalea con pleocitosis linfocitaria

et al. 2018

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Se presenta el caso de un paciente de 32 años, con historia de cefaleas de 10 años de evolución, que consulta al Servicio de Emergencias por cuadro subagudo de cefalea, asoció aura visual y parestesia en ambos miembros superiores. Sumado a esto, en la punción lumbar se documentó hipertensión endocraneal y pleocitosis linfocitaria. En el proceso diagnóstico se realizaron estudios que excluyen causas estructurales, vasculares, inflamatorias e infecciosas. De forma paralela, se le brindó tratamiento sintomático, durante el mismo presentó resolución clínica y a nivel de LCR control. El diagnóstico de síndrome de Headache and Neurological Deficits with cerebrospinalfluid Lymphocytosis (HaNDL) se realizó restrospectivamente. Este síndrome es poco frecuente o subdiagnosticado.En general, cursa con un buen pronóstico, a diferencia de sus diagnósticos diferenciales. La comprensión e identificación adecuadas de esta entidad evita complicaciones iatrogénicas.

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Syndrome of Transient Headache and Neurological Deficits with Cerebrospinal Fluid Lymphocytosis: HaNDL

Cited by 10 publications

References 5 publications

Recurrent headache in a five year old boy

Recurrent headache in a five year old boy

Confusional State in HaNDL Syndrome: Case Report and Literature Review

Síndrome de HaNDL: cefalea con pleocitosis linfocitaria

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