Syndrome sec et infection par le virus C de l'hépatite: un pseudosyndrome de Gougerot-Sjögren?

Extrahepatic manifestations of chronic hepatitis C

“…It has been reported that 10-20% of HCV patients have sicca symptoms of either the mouth or eyes (35)(36)(37), whereas Ͻ5% of patients with defined Sjögren's syndromes have HCV (38,39). Defined Sjögren's syndromes (defined by the presence of xerostomia, xerophthalmia, labial salivary gland histologic stages III or IV on the Chisholm scale, and anti-SSA or anti-SSB antibodies) are much rarer in HCV patients (38,(40)(41)(42). From the present series, however, we cannot rule out a stronger association between HCV and Sjögren's syndrome because our study did not focus on the presence of anti-extractable nuclear antigen antibodies or significant salivary gland abnormalities.…”

Whole stimulated salivary flow in patients with chronic hepatitis C virus infection

“…The simplicity and reproducibility of this technique makes it a method of choice for whole saliva collection (12). Although some authors (15, 16) have used unstimulated whole sialometry to evaluate salivary gland function in HCV infected patients, it has been suggested that the whole stimulated salivary flow rate could be especially useful in measuring salivary function in patients with common autoimmune disorders (17). The main advantage of gustatory stimulation, over the chewing method, is reduction in variability of salivary flow rates between individuals (12).…”

Oral manifestations of hepatitis C virus infection

“…Further studies [3,4,[44][45][46][47][48][49][50][51][52][53][54][55][56] have shown controversial results but up to 80% of HCV-infected individuals may have some salivary or lacrimal abnormality, frequently bling sialadenitis noted in humans [44,93] . Nests of lymphatic infiltrates were also noted in the LGs, but they occurred later and were less extensive than those found in the SGs.…”

“…June 28, 2014|Volume 20|Issue 24| WJG|www.wjgnet.com [61] 20 NA 10 Loustaud-Ratti et al [56] 26 NA 8 Mariette et al [62] 20 1 Fox Ⅰ 10 Barrier et al [63] 22 NA 9 Vidal et al [64] 28 1 Fox Ⅰ 14 Wattiaux et al [65] 109 European 3 Boscagli et al [50] 23 NA 5 Jorgensen et al [66] 62 European 19 Germany Potthoff et al [67] 73 2 AECG 18 Greece…”