Synergetic EGCG and coenzyme Q10 DSPC liposome nanoparticles protect against myocardial infarction

Abstract

At the site of myocardial infarction (MI), various phenomena such as oxidative stress and myocardial apoptosis were observed. Both Epigallocatechin gallate (EGCG) and Coenzyme Q10 (CoQ10) exhibited antioxidant and anti-inflammatory...

Advanced Nanomedicine Approaches for Myocardial Infarction Treatment

“…All these nanoparticles demonstrated effective anti-oxidant ability and efficacy for MI treatment in vitro or in vivo. Other antioxidants such as bilirubin, 71 epigallocatechin gallate (EGCG), and coenzyme Q10 (CoQ10) 72 were also loaded inside polymer and liposome nanoparticles, respectively, to effectively eradicate ROS, mitigate myocardial cell apoptosis, and improve cardiac function.…”

Stimuli-responsive polymer-based nanosystems for cardiovascular disease theranostics

“…191 Plaque rupture can contribute to myocardial infarction, and various strategies for scavenging reactive oxygen species (ROS) have recently been employed in the management of myocardial infarction. 192,193 Building upon the oxidation theory, numerous antioxidants have been investigated for their therapeutic potential by scavenging ROS. 194 In recent years, the application of natural antioxidants in the treatment of AS has gained attention due to their favourable safety profile; however, therapeutic strategies utilizing these antioxidants have been limited by inadequate elimination of ROS and unsatisfactory clinical outcomes.…”