Synergetic Hepatoprotective Effects of Korean Red Ginseng andPueraria Radixon the Liver Damaged-Induced by Carbon Tetrachloride (CCl₄) in Mice

Abstract

− This study was designed to investigate the synergetic hepatoprotective effects from a mixture of Korean Red Ginseng and Pueraria Radix on carbon tetrachloride (CCl 4 )-induced hepatotoxicity in mice. Liver toxicity was induced by intraperitoneal administration of CCl 4 (0.6 mg/kg) in 12 groups of ICR mice. The negative control group was given CCl 4 without test samples and the normal group was given no treatment. Among treatment groups, the RGAP treatment (Korean Red ginseng acetic acid extract : Pueraria radix water extract, w/ w, 38.4:57.6) decreased CCl 4 -elevated ALT (101.60 IU/L), AST (833.89 IU/L), and LDH (365.02 IU/L) levels in the serum, and increased the SOD (11.03 unit/mg protein) and CAT (0.37 unit/mg protein) levels and the LPO levels (59.09 µM/g tissue) more than that in the mice group with CCl 4 -induced control group hepatotoxicity. These results suggest that administration of a mixture of Korean Red ginseng and Pueraria radix decreases CCl 4 -induced liver damage and enhances antioxidant activity in mice and imply that administration of the mixture in a certain ratio is more effective than single administration of either Korean Red ginseng or Pueraria radix alone.

A Hydroxypropyl Methylcellulose-Based Solid Dispersion of Curcumin with Enhanced Bioavailability and Its Hepatoprotective Activity

“…The samples were allowed to clot, and serum was separated by centrifugation (1200× g , 15 min) then stored in −80 °C for experiments. The activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) was measured with a kit (ASAN Pharmaceutical Inc, Korea) according to the manufacturer’s instructions and previous report [19].…”

Beneficial Effects of Deoxyshikonin on Delayed Wound Healing in Diabetic Mice

“…Male Institute of Cancer Research (ICR) mice (4–5 weeks old) were obtained from Orient Bio Co., Ltd. (Seongnam, Korea). Mice were acclimatized under controlled standard conditions according to previous reports (temperature of 23 ± 2 °C, relative humidity of 50 ± 5% and illumination cycle of 12/12 h light/darkness, respectively) [ 36 , 37 ]. Diabetes was induced by the administration of 150 mg/kg streptozotocin (STZ).…”