Synergic effect of doxorubicin release and two-photon irradiation of Mn<sup>2+</sup>-doped Prussian blue nanoparticles on cancer therapy

Ali, Lamiaa M. A.; Mathlouthi, Emna; Cahu, Maëlle; Sene, Saad; Daurat, Morgane; Long, Jérôme; Guari, Yannick; Salles, Fabrice; Chopineau, Joël; Devoisselle, Jean-Marie; Larionova, Joulia; Gary‐Bobo, Magali

doi:10.1039/c9ra09133e

Cited by 11 publications

(8 citation statements)

References 40 publications

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“…In the case of PBA, LeBail refinement applied to the XRD pattern (Supplementary Material: Section 4, Figure S6) provides a solid argument that the space group is identified as Fm3m type having a unit cell parameter a = 10.2091(3) Å in good accordance with the results reported for similar samples [37][38][39].…”

Section: Resultssupporting

confidence: 80%

Heat Release Kinetics upon Water Vapor Sorption Using Cation-Exchanged Zeolites and Prussian Blue Analogues as Adsorbents: Application to Short-Term Low-Temperature Thermochemical Storage of Energy

et al. 2021

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In view of potential uses in short-term thermochemical heat storage by sorption of water vapor, the capacity to release a sufficient heat amount at the appropriate rate of a Prussian blue analogue (PBA) containing hexacyanocobaltate vacancies has been compared with those of 13X type zeolites possessing Na+, Ce3+, Ce4+, or Tb3+ extra-framework compensating cations. The extended structural and surface characterization demonstrated good reproducibility of the preparation procedures performed on a 10-g scale. The adsorbents were tested under dynamic conditions of gas flow with the aid of either a gas flow calorimeter (120 mL h−1 helium flow) to measure the amount and rate of the integral heat release or a laboratory-scale test rig (15,000 to 22,800 mL h−1 nitrogen flow) to monitor the outlet temperature of nitrogen heated by adsorption. For a regeneration temperature of 353 K and a partial H2O pressure of 2.8 kPa in helium, the PBA sample yielded an integral heat ranging between 900 and 1020 kJ kg−1 with a very slow heat release lasting for even 12–14 h. The zeolite-based materials generated between 350 and 950 kJ kg−1 more rapidly (up to 6–7 h), depending on the nature and the content of compensating cations, as well as on the dehydration state achieved during regeneration. With the laboratory-scale test rig, the efficiency of heat extraction by convection was about 65% for Na-13X and only 38% for PBA, and it diminished with decreasing flow rate.

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Section: Resultssupporting

confidence: 80%

Heat Release Kinetics upon Water Vapor Sorption Using Cation-Exchanged Zeolites and Prussian Blue Analogues as Adsorbents: Application to Short-Term Low-Temperature Thermochemical Storage of Energy

et al. 2021

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“…For this reason, Ali et al investigated the efficiency of combined PTT and chemotherapy to eradicate tumor cells and clearly reported a significant advantage of TPE laser irradiation over SPE irradiation under the same experimental conditions treated with nanoparticles (Figure 3). Data showed that, in the case of pulsed TPE at 808 nm, 91 % of cell death was found with 1@DOX 24 h after irradiation (Figure 3a), but the cells treated with 1@DOX only showed 35 % of cell death after 24 h of irradiation (808 nm, 2.5 W/cm −2 ) (Figure 3b) [95].…”

Section: Pbnps For Tumor Photothermal and Photodynamic Therapymentioning

confidence: 97%

“…Figure 3. Cell counting (%) of living MDA-MB-231 cells treated with Mn 2+ -doped PBNPs@DOX(1@DOX) and Mn 2+ -doped PBNPs (1) at 50 mg/mL and free DOX before irradiation and 24 h after irradiation with a TPE laser at 808 nm (3.7 W, 5% of total laser power) for 10 min (a) and with SPE at 808 nm (2.5 W cm −2 ) for 30 min (b), adapted with permission from ref [95]…”

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The Application of Prussian Blue Nanoparticles in Tumor Diagnosis and Treatment

Gao

Wang

Cheng

et al. 2020

Sensors

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Prussian blue nanoparticles (PBNPs) have attracted increasing research interest in immunosensors, bioimaging, drug delivery, and application as therapeutic agents due to their large internal pore volume, tunable size, easy synthesis and surface modification, good thermal stability, and favorable biocompatibility. This review first outlines the effect of tumor markers using PBNPs-based immunosensors which have a sandwich-type architecture and competitive-type structure. Metal ion doped PBNPs which were used as T1-weight magnetic resonance and photoacoustic imaging agents to improve image quality and surface modified PBNPs which were used as drug carriers to decrease side effects via passive or active targeting to tumor sites are also summarized. Moreover, the PBNPs with high photothermal efficiency and excellent catalase-like activity were promising for photothermal therapy and O2 self-supplied photodynamic therapy of tumors. Hence, PBNPs-based multimodal imaging-guided combinational tumor therapies (such as chemo, photothermal, and photodynamic therapies) were finally reviewed. This review aims to inspire broad interest in the rational design and application of PBNPs for detecting and treating tumors in clinical research.

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“…HUVECs were maintained in endothelial cell growth medium 2. Both media were supplemented according to the literature. , All cells were grown at 37 °C in a humidified atmosphere with 5% CO 2 .…”

Section: Methodsmentioning

confidence: 99%

“…Both media were supplemented according to the literature. [63][64] All cells were grown at 37°C in humidified atmosphere with 5% CO 2 .…”

Section: Cell Linesmentioning

confidence: 99%

Periodic Mesoporous Ionosilica Nanoparticles for Green Light Photodynamic Therapy and Photochemical Internalization of siRNA

Mezghrani

Ali

Richeter

et al. 2021

ACS Appl. Mater. Interfaces

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We report Periodic Mesoporous Ionosilica Nanoparticles (PMINPs) as versatile nano-objects for imaging, photodynamic therapy (PDT), and efficient adsorption and delivery of siRNA into breast cancer cells. In order to endow these nanoparticles PDT and siRNA photochemical internalization (PCI) properties, a porphyrin derivative was integrated into the ionosilica framework. For this purpose, we synthesized PMINPs via hydrolysis-cocondensation procedures from oligosilylated ammonium and porphyrin precursors. The formation of these nanoobjects was attested by TEM. The formed nanoparticles were then thoroughly characterized via solid state NMR, nitrogen sorption, DLS, UV-Vis and fluorescence spectroscopy. Our results indicate the formation of highly porous nanorods with a length of 108 ± 9 nm and a width of 54 ± 4 nm. A significant PDT effect of type I mechanism (95 ± 2.8% of cell death) was observed upon green light irradiation in nanoparticles treated-breast cancer cells, while the blue light irradiation caused a significant phototoxic effect in non-treated cells. Furthermore, PMINPs formed stable complexes with siRNA (up to 24 h), which were efficiently internalized into the cells after 4 h of incubation mostly with energy-dependent endocytosis process. The PCI effect was obvious with green light irradiation and successfully led to 83 ± 1.1% silencing of luciferase gene in luciferase expressing breast cancer cells, while no gene silencing effect was observed with blue light irradiation. The present work highlights the high potential of porphyrin-doped PMINPs as multifunctional nanocarriers for nucleic acids, such as siRNA, with a triple ability to perform imaging, PDT and PCI.

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Synergic effect of doxorubicin release and two-photon irradiation of Mn²⁺-doped Prussian blue nanoparticles on cancer therapy

Abstract: Mn2+-doped Prussian blue nanoparticles loaded with doxorubicin present high efficiency for combined photothermal and chemotherapy of cancer cells with a synergic effect under two-photon irradiation.

Cited by 11 publications

References 40 publications

Heat Release Kinetics upon Water Vapor Sorption Using Cation-Exchanged Zeolites and Prussian Blue Analogues as Adsorbents: Application to Short-Term Low-Temperature Thermochemical Storage of Energy

Heat Release Kinetics upon Water Vapor Sorption Using Cation-Exchanged Zeolites and Prussian Blue Analogues as Adsorbents: Application to Short-Term Low-Temperature Thermochemical Storage of Energy

The Application of Prussian Blue Nanoparticles in Tumor Diagnosis and Treatment

Periodic Mesoporous Ionosilica Nanoparticles for Green Light Photodynamic Therapy and Photochemical Internalization of siRNA

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Synergic effect of doxorubicin release and two-photon irradiation of Mn2+-doped Prussian blue nanoparticles on cancer therapy

Abstract: Mn2+-doped Prussian blue nanoparticles loaded with doxorubicin present high efficiency for combined photothermal and chemotherapy of cancer cells with a synergic effect under two-photon irradiation.

Cited by 11 publications

References 40 publications

Heat Release Kinetics upon Water Vapor Sorption Using Cation-Exchanged Zeolites and Prussian Blue Analogues as Adsorbents: Application to Short-Term Low-Temperature Thermochemical Storage of Energy

Heat Release Kinetics upon Water Vapor Sorption Using Cation-Exchanged Zeolites and Prussian Blue Analogues as Adsorbents: Application to Short-Term Low-Temperature Thermochemical Storage of Energy

The Application of Prussian Blue Nanoparticles in Tumor Diagnosis and Treatment

Periodic Mesoporous Ionosilica Nanoparticles for Green Light Photodynamic Therapy and Photochemical Internalization of siRNA

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Synergic effect of doxorubicin release and two-photon irradiation of Mn²⁺-doped Prussian blue nanoparticles on cancer therapy