Synergic effects of artemisinin and resveratrol in cancer cells

Li, Peichun; Yang, Sen; Dou, Mengmeng; Chen, Youran; Zhang, Jie; Zhao, Xiaoyan

doi:10.1007/s00432-014-1771-7

Cited by 29 publications

(17 citation statements)

References 35 publications

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“…Many studies show the synergistic effects of ARTs with other compounds or therapeutic approaches. The combined treatment of ART and resveratrol markedly inhibits cell proliferation and migration, and enhances apoptosis and ROS production in human cervical cancer HeLa and hepatocellular carcinoma HepG2 cells [213]. Similarly, the use of combined DHA and gemcitabine exhibits strong synergistic effects on the loss of mitochondrial membrane potential and induction of apoptosis in human NSCLC A549 cells [214].…”

Section: Artemisininsmentioning

confidence: 99%

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

et al. 2019

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Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer activities, including antiproliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects, as well as regulate autophagy, reverse multidrug resistance, balance immunity, and enhance chemotherapy in vitro and in vivo. To provide new insights into the critical path ahead, we systemically reviewed the most recent advances (reported since 2011) on the key compounds with anti-cancer effects derived from Chinese herbal medicine (curcumin, epigallocatechin gallate, berberine, artemisinin, ginsenoside Rg3, ursolic acid, silibinin, emodin, triptolide, cucurbitacin B, tanshinone I, oridonin, shikonin, gambogic acid, artesunate, wogonin, β-elemene, and cepharanthine) in scientific databases (PubMed, Web of Science, Medline, Scopus, and Clinical Trials). With a broader perspective, we focused on their recently discovered and/or investigated pharmacological effects, novel mechanism of action, relevant clinical studies, and their innovative applications in combined therapy and immunomodulation. In addition, the present review has extended to describe other promising compounds including dihydroartemisinin, ginsenoside Rh2, compound K, cucurbitacins D, E, I, tanshinone IIA and cryptotanshinone in view of their potentials in cancer therapy. Up to now, the evidence about the immunomodulatory effects and clinical trials of natural anti-cancer compounds from Chinese herbal medicine is very limited, and further research is needed to monitor their immunoregulatory effects and explore their mechanisms of action as modulators of immune checkpoints.

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Section: Artemisininsmentioning

confidence: 99%

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

et al. 2019

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“…The finding was in agreement with previous studies, where it has been reported that deguelin, a flavonoid compound increase antitumor activity of cisplatin against gastric cancer cells. 16 Furthermore, another study also reported that triptolide, a diterpene from Tripterygium wilfordii in combination with cisplatin produced a synergistic anticancer effect in gastric cancer cells. By this combination, triptolide increased apoptosis effect of cisplatin through activation of caspase-3 and caspase-9.…”

Section: Resultsmentioning

confidence: 99%

“…Synergistic study − The interaction of flavonoid compounds with cisplatin was determined using an isobologram analysis as previously described with slight modification. 16 Briefly, the dose-dependent effects of each compounds and fixed concentrations of compound were determined using MTT assay. The cells were then treated with a combination of flavonoid compounds and cisplatin.…”

Section: Percentage Inhibition (%) =mentioning

confidence: 99%

Synergistic Effect of Flavonoids fromArtocarpus heterophyllusHeartwoods on Anticancer Activity of Cisplatin Against H460 and MCF-7 Cell Lines

et al. 2019

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Artocarpus heterophyllus has been used as traditional medicine. This plant is one of the sources of flavonoid. Flavonoid compounds possessed a wide range of biological properties including anticancer. This study was performed to investigate the cytotoxic effect of flavonoids from A. heterophyllus on H460 and MCF-7 cell lines. The interaction of flavonoids and cisplatin against tested cancer cells was also evaluated. MTT assay was used to determine the cytotoxic effect of flavonoid. Isobologram analysis was selected to evaluate the synergistic effect between flavonoid and cisplatin, their interaction was then confirmed using AO/PI staining method. Amongst of flavonoid compounds, artocarpin exhibited strong cytotoxic effect on both MCF-7 and H460 cell lines with IC 50 values of 12.53 µg/mL (28.73 µM) and 9.77 µg/mL (22.40 µM), respectively. This compound enhanced anticancer activity of cisplatin against H460 and MCF-7. The combination produced a synergistic effect on H460 and MCF-7 cell lines with a combination index (CI) values of 0.2 and 0.18, respectively. The AO/ PI stained demonstrated that the combination of artocarpin and cisplatin caused morphological changes that indicated apoptosis. Moreover, artocarpanone also significantly increased cytotoxic effect of cisplatin compared to its single concentration with CI below than 1. This result suggested the potency of flavonoid named artocarpin to enhance the anticancer activity of cisplatin on H460 and MCF-7 cell lines.

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“…The proportion of apoptosis (sub-G1 cell cycle accumulation) and DNA fragmentation were increased more significantly by the combination compared to single-agent treatments [37]. Resveratrol elicited more significant inhibitory effects on ovarian and hepatocellular carcinoma cells when combined with artemisinin at a ratio of 2:1 by increasing apoptosis, ROS levels and by decreasing migratory ability [38]. Combinations of resveratrol with matrine, genistein and arsenic trioxide have been used in the treatment of hepatoma, breast cancer and acute and chronic myeloid leukemias [39-41].…”

Section: Synergistic Effects Of Chm Compounds Chms Combinations and mentioning

confidence: 99%

Advances in Synergistic Combinations of Chinese Herbal Medicine for the Treatment of Cancer

Hu¹,

Sun²,

Lau³

et al. 2016

CCDT

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The complex pathology of cancer development requires correspondingly complex treatments. The traditional application of individual single-target drugs fails to sufficiently treat cancer with durable therapeutic effects and tolerable adverse events. Therefore, synergistic combinations of drugs represent a promising way to enhance efficacy, overcome toxicity and optimize safety. Chinese Herbal Medicines (CHMs) have long been used as such synergistic combinations. Therefore, we summarized the synergistic combinations of CHMs used in the treatment of cancer and their roles in chemotherapy in terms of enhancing efficacy, reducing side effects, immune modulation, as well as abrogating drug resistance. Our conclusions support the development of further science-based holistic modalities for cancer care.

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Synergic effects of artemisinin and resveratrol in cancer cells

Abstract: Taken together, the present study suggested that ART and Res possessed the synergistic anti-tumor effect. ART in combination with Res could be an effective therapeutic strategy for cancer.

Cited by 29 publications

References 35 publications

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Synergistic Effect of Flavonoids fromArtocarpus heterophyllusHeartwoods on Anticancer Activity of Cisplatin Against H460 and MCF-7 Cell Lines

Advances in Synergistic Combinations of Chinese Herbal Medicine for the Treatment of Cancer

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