Synergic effects of ultrasound and ionic liquids on fluconazole emulsion

Hennemann, Bruno L.; Moleta, Guilherme S.; Fuchs, Ana L.; Villetti, Marcos A.; Kuhn, Bruna L.; Rampelotto, Camila Reck; Paz, Alisson V.; Silva, Cristiane de Bona da; Frizzo, Clarissa P.

doi:10.1016/j.ultsonch.2020.105446

Cited by 11 publications

(7 citation statements)

References 64 publications

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“…NaCS resulted in lower span values, which indicates a more homogeneous emulsion with similar droplet size compared to WPI. Hennemann et al 27 reported that when the power level of HIUS increased from 20 to 40%, the span value increased slightly due to high energy, leading to more collision and aggregation of particles. The span was also close to 1 in this study, which shows heterogeneity of the droplet size, especially in the case of WPI.…”

Section: Resultsmentioning

confidence: 99%

Stabilization of Olive Oil in Water Emulsion with Dairy Ingredients by Pulsed and Continuous High Intensity Ultrasound

2023

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Application of high intensity ultrasound (HIUS) for stabilization of olive oil in water emulsion with different dairy ingredients including sodium caseinate (NaCS) and whey protein isolate (WPI) was investigated. The emulsions were prepared by homogenization with a probe and then treated with either a second homogenization or HIUS at a different power level (20 and 50%) in pulsed or continuous mode for 2 min. The emulsion activity index (EAI), creaming index (CI), specific surface area (SSA), rheological properties, and droplet size of the samples were determined. The temperature of the sample rose when HIUS was applied in continuous mode and at increasing power level. HIUS treatment increased EAI and SSA of the emulsion and decreased droplet size and CI compared with those of the double-homogenized sample. Among the HIUS treatments, the highest EAI was found in the emulsion with NaCS that was treated at a power level of 50% in continuous mode, and the lowest one was obtained by HIUS applied at a power level of 20% in pulsed mode. SSA, droplet size, and span of the emulsion were not affected by HIUS parameters. Rheological properties of HIUS-treated emulsions were not different from those of the double-homogenized control sample. Continuous HIUS at 20% power level and pulsed HIUS at 50% power level reduced creaming in the emulsion after storage at a similar level. HIUS at a low power level or in pulsed mode can be preferred for heat sensitive materials.

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Section: Resultsmentioning

confidence: 99%

Stabilization of Olive Oil in Water Emulsion with Dairy Ingredients by Pulsed and Continuous High Intensity Ultrasound

2023

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“…The ILs were synthesized following the methodology previously described in the literature and adapted in our laboratory [21,22]; the updated synthesis methodology is reported in reference [16]. All ILs were characterized by electrospray ionization mass spectrometry (ESI-MS) and 1 H and 13 C nuclear magnetic resonance (NMR) spectroscopy using D 2 O as a solvent [16].…”

Section: Synthesismentioning

confidence: 99%

“…Emulsion preparation via magnetic stirring (MS) and ultrasound (US) and characterization data (e.g., polydispersity and viscosity) are described in detail in reference [16].…”

Section: Preparation Of Emulsionsmentioning

confidence: 99%

“…Furthermore, due to the possibility of changes being made to the cation, anion, and/or the alkyl chain of these ILs' structures, their properties can be easily adjusted according to the limitation to be overcome [12][13][14][15]. In a previous study, we presented the encapsulation of fluconazole using the imidazoliumbased ILs-[C 12 MIM]Br or [C 16 MIM]Br-through the formation of emulsions assisted by either US irradiation (at amplitudes of 20% and 40%) or magnetic stirring [16]. The results showed that the emulsion prepared using US at an amplitude of 40% resulted in increased encapsulation efficiency, lower viscosities, and better control of drug release.…”

Section: Introductionmentioning

confidence: 99%

“…The results showed that the emulsion prepared using US at an amplitude of 40% resulted in increased encapsulation efficiency, lower viscosities, and better control of drug release. Additionally, emulsions based on [C 16 MIM]Br presented a smaller droplet size with a spherical shape and smaller polydispersity (span index), indicating increased preliminary stability.…”

Section: Introductionmentioning

confidence: 99%

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Antifungal Activity and Stability of Fluconazole Emulsion Containing Ionic Liquids Explained by Intermolecular Interactions

et al. 2022

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This research reports accelerated stability experiments, the evaluation of intermolecular interactions, and antifungal assays for fluconazole emulsions prepared using ultrasound (US) and magnetic stirring (MS) in the presence of ionic liquids derived from 1,n-(3-methylimidazolium-1-yl)alkane bromide ([CnMIM]Br; n = 12 or 16). The goals of the investigation are to quantify the stability, identify the forces that drive the formation and stability, and determine the antifungal activity of fluconazole-containing emulsions, and corroborate the data from our previous results that indicated that the emulsion based on [C16MIM]Br seemed to be more stable. In this study, accelerated stability experiments evidenced a considerable stability for the [C16MIM]Br emulsions at two temperatures (25 and 37 °C)—the instability index increased in the following order: US40% < US20% < MS. The 1H NMR data showed that the ILs interacts differently with medium-chain triglycerides (MCT). Two distinct interaction mechanisms were also observed for [C12MIM]Br and [C16MIM]Br with fluconazole, in which the latter formed more compact mixed aggregates than the former. The result was corroborated by diffusion data, which showed that ILs suffered a decrease in diffusion in the presence of fluconazole. The antifungal assay showed that emulsions containing ILs displayed superior activity compared with fluconazole alone. The emulsions also showed potent activity in inhibiting a resistant species (C. glabrata—CG34) to FLZ. All emulsions showed weak irritant potential in HET-CAM assay.

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Efficient synthetic strategies for fused pyrimidine and pyridine derivatives: A review

Anjirwala,

Patel

2024

Journal of Heterocyclic Chem

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Pyrimidine and its derivatives play a paramount role in drug discovery as privileged pharmacophores with considerable chemical and biological significance and its presence in genes. This review aims to assemble a systematic evaluation of synthetic tactics of various fused pyrimidine derivatives containing nitrogen heterocycles such as pyridopyridines, pyridopyrimidines, and pyrimidopyrimidine from a pharmacological point of view and deliver an overview of methodologies presenting the chemistry of fused pyrimidine derivatives. The review details the importance of various catalysts and ring substitution using various electrophilic and nucleophilic reagents. These synthetic strategies were elaborated based on the different synthetic routes that lead to the specific type of pyrimidine and pyridine fused derivatives. The literature accumulates various developments in one‐pot condensation, the Knoevenagel–Michael addition mechanism, microwave and ultrasound irradiation, intramolecular cyclization, nano‐catalytic reactions, and so forth. Short reaction times, catalyst reusability, solvent‐free conditions, excellent yields, and stereo‐selectivity are some of the benefits of certain synthetic approaches.

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Synergic effects of ultrasound and ionic liquids on fluconazole emulsion

Cited by 11 publications

References 64 publications

Stabilization of Olive Oil in Water Emulsion with Dairy Ingredients by Pulsed and Continuous High Intensity Ultrasound

Stabilization of Olive Oil in Water Emulsion with Dairy Ingredients by Pulsed and Continuous High Intensity Ultrasound

Antifungal Activity and Stability of Fluconazole Emulsion Containing Ionic Liquids Explained by Intermolecular Interactions

Efficient synthetic strategies for fused pyrimidine and pyridine derivatives: A review

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