Synergic fabrication of multifunctional liposomes nanocomposites for improved radiofrequency ablation combination for liver metastasis cancer therapy

Abstract

The field of biomedical research has recently been interested in nanoplatforms with various functionalities, such as cancer drug carriers and MRI and optical imaging, as well as thermal treatment, among other things. As a result of the present investigation, a unique multifunctional liposome (MFL) was established in this investigation. Using radiofrequency-induced imaging and drug release based on magnetic field impact, a dual drug delivery targeted with tumor multi-mechanism treatment was made more effective. The C60 (fullerene) surface was coated with iron nanocomposites to establish the proposed nanosystems, and PEGylation was used (Fe 3 O 4 -C60-PEG 2000 ). For fullerene radiofrequency-triggered drug release, thermosensitive DPPC liposomes with folate-DSPE-PEG 2000 enveloped the binary nanosystems and doxorubicin (DOX). The in vitro cytotoxicity of the nanocomposites was confirmed by the liver metastasis in HT-29 colon cancer cells using radiofrequency. The flow cytometry analysis confirmed the apoptosis cell death mechanism. The thermal treatment combined chemotherapeutic MFL nano framework transformed radiofrequency radiation from thermoresponsive liposomes, which was noticed both in vivo and in vitro . Due to their superior active tumor targeting and magnetic targeting characteristics, the MFL could also selectively destroy cancerous liver cells in highly co-localized targets.

Targeting the Gut: A Systematic Review of Specific Drug Nanocarriers

“…More recently, such stimuli have been coupled to nanocarriers, thus enabling new types of drug delivery, which improve the specificity of release in the desired body region. This is the case, for example, with colon cancer treatment through liposomes, where their dissolution can be activated by external stimuli, such as a magnetic field or light, when they reach the correct location for drug delivery [ 208 , 209 , 210 , 211 ]. As already reported, SPIONs magnetize in response to an external magnetic field.…”

Dual-Target Multifunctional Superparamagnetic Cationic Nanoliposomes for Multimodal Imaging-Guided Synergistic Photothermal/Photodynamic Therapy of Retinoblastoma

“…Secondly, PFH, ICG and SPIONs were used as multifunctional components of FCNPIFEs to simultaneously realize the functions of imaging /treatment or imaging/targeting, simplifying the synthesis process to some extent and reducing the synthesis cost compared with the other such theranostics nanoparticles. 51 , 52 Thirdly, ICG could display remarkable photothermal and photodynamic effects under the same laser excitation. Though the PDT efficacy of ICG was limited by hypoxia in tumors due to the high oxygen dependency, PFH in FCNPIFEs showed outstanding oxygen reserve capacity and effectively alleviated intratumor hypoxia.…”

Advanced Drug Carriers: A Review of Selected Protein, Polysaccharide, and Lipid Drug Delivery Platforms

“…An interesting solution has been additionally investigated by Zhang et al [55]. Here, multifunctional liposomal carriers of doxorubicin composed of fullerene and magnetic iron oxide nanoparticles combined with poly(ethylene glycol) have been developed.…”