Synergic Topological- and Size-Control on Phosphazane Chemistry: First Unfolded Hybrid Tetrameric Macrocycle

Abstract

Herein, we report an unprecedented combination of pre-arranged building blocks and a multi-step synthetic route to rationally and simultaneously enable access to an unfolded tetrameric macrocycle, which is not accessible using conventional synthetic strategies. The obtained macrocycle, cis-[μ-P(μ-NtBu)]2(μ-p-OC6H4C(O)O)]4[μ-P(μ-NtBu)]2 (4), is the first unfolded open-face hybrid cyclodiphosphazane macrocycle reported and displays a cavity area of 110.1 Å2 - the largest of its kind.<br>

Recent Advances in the Synthesis and Applications of Nitrogen-Containing Macrocycles

“…The synthesis and properties of macrocycles possessing inorganic atoms in their core structure is still a demanding task. Cyclodiphosphazane-containing macrocycles were recently explored as a candidates for supramolecular-structures building blocks, but the synthesis of larger macrocycles is still under development [ 60 ]. The traditional one-step approach usually leads to smaller macrocycles, and in the cases of asymmetric linkers, it results in mixed exo / endo arrangement in the macrocycle backbone.…”