Synergism among Oral Carcinogens, Ill. Simultaneous Feeding of Four Bladder Carcinogens to Dogs

Deichmann, William B.; Radomski, Jack L.; Gläss, Eberhard; Anderson, W. A. D.; Coplan, Milton M.; Woods, Frank M.

doi:10.1097/00043764-196603000-00031

Cited by 2 publications

(3 citation statements)

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“…Epidemiological surveys in US chemical plants indicate a high incidence of bladder cancer among workers exposed to 4-ABP (308,309). Oral 4-ABP administration has been reported to result in an increased incidence of angiosarcoma in mice of both genders; bladder carcinoma and HCC in male and female mice, respectively (310,311); and bladder carcinoma in dogs of both genders (312,313). Subcutaneous (314) or intraperitoneal injection (315,316) have been demonstrated to increase HCC incidence in male mice.…”

Section: Resultsmentioning

confidence: 99%

“…Animal studies have demonstrated that administration to dogs results in formation of N -(deoxyguanonsin-8-yl)-4-ABP (dG-C8-ABP) as the major DNA adduct (~70% of total adducts) in hepatocytes and bladder cells (319,320). In BALB/c mice, a linear association has been described between dG-C8-ABP levels in liver DNA and liver tumor incidence (312). In human liver tissue, higher 4-ABP-DNA levels were observed in HCC cases compared with controls (321–323).…”

Section: Resultsmentioning

confidence: 99%

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Non-infective occupational risk factors for hepatocellular carcinoma: A review

Ledda

Loreto

Zammit

et al. 2016

Molecular Medicine Reports

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Liver cancer is the second leading worldwide cause of cancer-associated mortalities. Hepatocellular carcinoma, which accounts for the majority of liver tumors, ranks fifth among types of human cancer. Well-established risk factors for liver cancer include the hepatitis B and C viruses, aflatoxins, alcohol consumption, and oral contraceptives. Tobacco smoking, androgenic steroids, and diabetes mellitus are suspected risk factors. Current knowledge regarding non-infective occupational risk factors for liver cancer is inconclusive. The relevance of liver disorders to occupational medicine lies in the fact that the majority of chemicals are metabolized in the liver, and toxic metabolites generated via metabolism are the predominant cause of liver damage. However, their non-specific clinical manifestations that are similar in a number of liver diseases make diagnosis difficult. Furthermore, concomitant conditions, such as viral hepatitis and alcohol or drug abuse, may mask liver disorders that result from occupational hepatotoxic agents and block the demonstration of an occupational cause. The identification of environmental agents that result in human cancer is a long and often difficult process. The purpose of the present review is to summarize current knowledge regarding the association of non-infective occupational risk exposure and HCC, to encourage further research and draw attention to this global occupational public health problem.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Non-infective occupational risk factors for hepatocellular carcinoma: A review

Ledda

Loreto

Zammit

et al. 2016

Molecular Medicine Reports

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show abstract

“…In experimental carcinogenesis there are examples of an apparent enhancement or antagonism between two chemicals (Miller and Miller, 1953;Miller et al, 1958;Falk and Kotin, 1963;Deichmann et al, 1965), or between dietary conditions and a chemical (Miller and Miller, 1953;Sugai et al, 1962), or between the hormonal environment and a chemical (Furth, 1961;Weisburger et al, 1964).…”

mentioning

confidence: 99%