2012
DOI: 10.1016/j.toxicon.2011.11.007
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Synergism between baltergin metalloproteinase and Ba SPII RP4 PLA2 from Bothrops alternatus venom on skeletal muscle (C2C12) cells

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Cited by 46 publications
(23 citation statements)
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“…The PLA 2 family has recently been regarded a promising target for broad spectrum antivenom drug development, due to their wide-distribution, high content, and diverse toxicological effects [ 25 ]. Previous studies revealed that PLA 2 s acts with other toxic components in a synergistic manner, mostly zinc-dependent metalloproteinases, which are responsible for hemorrhage, blistering, and necrosis [ 26 , 27 , 28 ]. The anti-PLA 2 IgGs developed from Ba spII RP4 PLA 2 (a non-toxic PLA 2 from Bothrops alternates venom) could inhibit haemolysis and myotoxicity of the crude venom, and also decreased 50% of mortality of mice dosed with four times the LD 50 .…”
Section: Discussionmentioning
confidence: 99%
“…The PLA 2 family has recently been regarded a promising target for broad spectrum antivenom drug development, due to their wide-distribution, high content, and diverse toxicological effects [ 25 ]. Previous studies revealed that PLA 2 s acts with other toxic components in a synergistic manner, mostly zinc-dependent metalloproteinases, which are responsible for hemorrhage, blistering, and necrosis [ 26 , 27 , 28 ]. The anti-PLA 2 IgGs developed from Ba spII RP4 PLA 2 (a non-toxic PLA 2 from Bothrops alternates venom) could inhibit haemolysis and myotoxicity of the crude venom, and also decreased 50% of mortality of mice dosed with four times the LD 50 .…”
Section: Discussionmentioning
confidence: 99%
“…alternatus and B . jararacussu show cytotoxic effect on muscle cells [ 43 , 44 ]. svMPs with cytotoxic effect include the ones isolated from B .…”
Section: Discussionmentioning
confidence: 99%
“…asper [ 45 , 46 ]. The effects observed in Bothrops and Bothropoides venoms are probably due to a synergic and/or additive effect between these and other fractions with cytotoxic effect [ 43 ]. An important aspect of B .…”
Section: Discussionmentioning
confidence: 99%
“…The search for in vitro tests that would substitute in vivo assays, such as lethality and determination of hemorrhagic, myotoxic, dermonecrotic, and defibrinogenating activities, has been difficult due to the complex biochemical and toxicological nature of snake venoms, whereby toxicity is often determined by several toxins acting together in synergistic and additive fashions [102,103]. For neurotoxic venoms, the use of ex vivo neuromuscular preparations is useful for assessing neuromuscular blockade and its neutralization [79,104,105].…”
Section: Implementation Of the 3rs In Antivenom Testingmentioning
confidence: 99%