Synergism between Soluble and Dietary Fiber Bound Antioxidants

Çelik, Ecem Evrim; Gökmen, Vural; Skibsted, Leif H.

doi:10.1021/acs.jafc.5b00009

Cited by 33 publications

(10 citation statements)

References 34 publications

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“…As a consequence, the insoluble material with an increased antioxidant capacity was obtained (Çelik and Gökmen ). Furthermore, the interaction between insoluble and soluble antioxidant compounds was investigated using liposome‐based and electron‐spin resonance‐based systems (Çelik and others ). The synergistic interaction between soluble and insoluble antioxidant compounds was observed in both systems as an interaction of a radical scavenger and a secondary lipid oxidation inhibitor (Figure ).…”

Section: Interaction Between Soluble and Bound Antioxidant Compoundsmentioning

confidence: 99%

“…The synergistic interaction between soluble and insoluble antioxidant compounds was observed in both systems as an interaction of a radical scavenger and a secondary lipid oxidation inhibitor (Figure ). It was reported that the synergistic effects of the soluble antioxidants in various beverages depend on the nature of the antioxidant compounds, their concentrations, and their proportion in the mixture of insoluble and soluble antioxidants (Çelik and others ). It was also emphasized that the proposed regeneration concept may be similarly validated for different parts of the gastrointestinal tract, and the beneficial effects of bound antioxidants may persist for a long time because of the regenerative behavior of soluble antioxidant compounds.…”

Section: Interaction Between Soluble and Bound Antioxidant Compoundsmentioning

confidence: 99%

“…Synergistic antioxidant mechanism of bound antioxidants via regeneration by free soluble antioxidants in (A) the liposome system and (B) ESR‐based system (Çelik and others ).…”

Section: Interaction Between Soluble and Bound Antioxidant Compoundsmentioning

confidence: 99%

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Antioxidants Bound to an Insoluble Food Matrix: Their Analysis, Regeneration Behavior, and Physiological Importance

Cömert

Gökmen

2017

Comp Rev Food Sci Food Safe

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Dietary antioxidants play an important role in human health by counteracting oxidative stress and preventing chronic diseases. Most common dietary antioxidants in foods are vitamins, carotenoids, phenolic compounds, sulfurcontaining compounds, and neoformed antioxidants. Antioxidants may be present in free soluble or bound insoluble forms in foods. Antioxidants bound to insoluble food matrices have gained the spotlight because they exert their antioxidant effects much longer than free soluble ones. A direct procedure called QUENCHER has been shown to accurately measure the antioxidant capacity of antioxidants bound to insoluble matrices. This procedure overcomes the drawbacks of extraction-dependent classical assays leading to underestimation of the total antioxidant capacity (TAC) of foods. This review focuses on antioxidants that are found naturally in foods or are formed in foods during processing specifically the antioxidants bound to the insoluble food matrices. The literature gap on the importance of bound antioxidants, their physiological relevance, and methods for measurement of their antioxidant capacity will be filled by this comprehensive review. In particular, chemical properties and health effects of food antioxidants, measurement of the TAC of foods by the QUENCHER method, digestion behavior of bound insoluble antioxidants, and their interactions with free soluble antioxidants are discussed throughout this review.

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Section: Interaction Between Soluble and Bound Antioxidant Compoundsmentioning

confidence: 99%

Section: Interaction Between Soluble and Bound Antioxidant Compoundsmentioning

confidence: 99%

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Antioxidants Bound to an Insoluble Food Matrix: Their Analysis, Regeneration Behavior, and Physiological Importance

Cömert

Gökmen

2017

Comp Rev Food Sci Food Safe

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“…The gut may be a major site of action for these antioxidants [270,271], and protective effects may involve both insoluble antioxidants and antioxidants that are solubilized by partial digestion [272]. In fact, it has been reported that there is a synergistic effect between soluble antioxidants and dietary-fiber bound insoluble antioxidants [273,274] with suggested mechanisms involving the oxidative grafting of soluble phenolics to fiber-based amines [275].…”

Section: Probing For Redox Properties Of Dietary Antioxidantsmentioning

confidence: 99%

Electrochemical reverse engineering: A systems-level tool to probe the redox-based molecular communication of biology

Liu

Kim

et al. 2017

Free Radical Biology and Medicine

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The intestine is the site of digestion and forms a critical interface between the host and the outside world. This interface is composed of host epithelium and a complex microbiota which is "connected" through an extensive web of chemical and biological interactions that determine the balance between health and disease for the host. This biology and the associated chemical dialogues occur within a context of a steep oxygen gradient that provides the driving force for a variety of reduction and oxidation (redox) reactions. While some redox couples (e.g., catecholics) can spontaneously exchange electrons, many others are kinetically "insulated" (e.g., biothiols) allowing the biology to set and control their redox states far from equilibrium. It is well known that within cells, such non-equilibrated redox couples are poised to transfer electrons to perform reactions essential to immune defense (e.g., transfer from NADH to O for reactive oxygen species, ROS, generation) and protection from such oxidative stresses (e.g., glutathione-based reduction of ROS). More recently, it has been recognized that some of these redox-active species (e.g., HO) cross membranes and diffuse into the extracellular environment including lumen to transmit redox information that is received by atomically-specific receptors (e.g., cysteine-based sulfur switches) that regulate biological functions. Thus, redox has emerged as an important modality in the chemical signaling that occurs in the intestine and there have been emerging efforts to develop the experimental tools needed to probe this modality. We suggest that electrochemistry provides a unique tool to experimentally probe redox interactions at a systems level. Importantly, electrochemistry offers the potential to enlist the extensive theories established in signal processing in an effort to "reverse engineer" the molecular communication occurring in this complex biological system. Here, we review our efforts to develop this electrochemical tool for in vitro redox-probing.

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“…Carotenoids in whole grains include lutein, alpha-carotene, beta-carotene and beta-cyproxanthin, are found in the bran and germ layers of whole grains, can also serve as antioxidants [63]. Further, antioxidant capacity is inherent in insoluble grain fibers [64, 65]. Phytic acid is common phytochemical in many whole grains, and is well known as an antioxidant that represses iron-catalyzed redox reactions [66, 67].…”

Section: Introductionmentioning

confidence: 99%

Whole Grains in Amelioration of Metabolic Derangements

Yadav¹

2016

JNHFS

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Daily diet influences whole body metabolism, and intricately linked to the prevention or progression of metabolic diseases including obesity, diabetes and cardiovascular diseases. Several epidemiological and large scale studies have shown that diets enriched with whole grains improves metabolic function and protect from the development of metabolic diseases. Direct impact of whole grain diet can be mediated on several levels of metabolic functions i.e. reduced glycemic index, improved fat oxidation potential, increased cholesterol clearance or decreased cholesterol biosynthesis and modulation of gut microbiome. In this article we reviewed several studies indicating the beneficial effects of whole grain diets on metabolic functions, as well as discussed the potential active phytochemicals present in these whole grain foods to contribute in modulation of metabolic function in our body.

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Synergism between Soluble and Dietary Fiber Bound Antioxidants

Cited by 33 publications

References 34 publications

Antioxidants Bound to an Insoluble Food Matrix: Their Analysis, Regeneration Behavior, and Physiological Importance

Antioxidants Bound to an Insoluble Food Matrix: Their Analysis, Regeneration Behavior, and Physiological Importance

Electrochemical reverse engineering: A systems-level tool to probe the redox-based molecular communication of biology

Whole Grains in Amelioration of Metabolic Derangements

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