2014
DOI: 10.1016/j.rbmo.2014.04.008
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Synergism between the N-acetyltransferase 2 gene and oxidant exposure increases the risk of idiopathic male infertility

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Cited by 13 publications
(11 citation statements)
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References 70 publications
(71 reference statements)
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“…This approach was proposed to overcome a problem of contradictory results between genetic association studies of male infertility and to better understand the mechanisms by which environmental factors provoke the disease in genetically susceptible men. Although such investigations are yet in their infancy, the results of our recent studies clearly demonstrated that oxidant and antioxidant exposures of the environment may potentiate the development of male infertility and their effects mediated by polymorphic genes for antioxidant and xenobiotic‐metabolising enzymes (Yarosh et al ., , ). It is known that smoking status may mask the relationship between polymorphism of GST genes and male infertility risk.…”
Section: Discussionmentioning
confidence: 97%
See 1 more Smart Citation
“…This approach was proposed to overcome a problem of contradictory results between genetic association studies of male infertility and to better understand the mechanisms by which environmental factors provoke the disease in genetically susceptible men. Although such investigations are yet in their infancy, the results of our recent studies clearly demonstrated that oxidant and antioxidant exposures of the environment may potentiate the development of male infertility and their effects mediated by polymorphic genes for antioxidant and xenobiotic‐metabolising enzymes (Yarosh et al ., , ). It is known that smoking status may mask the relationship between polymorphism of GST genes and male infertility risk.…”
Section: Discussionmentioning
confidence: 97%
“…Although exact reasons of inconsistent results across the genetic association studies in different ethnicities are not yet fully understood, the absence of association between GST genes alone and male infertility risk in some populations of the world may be attributed to gene–gene and gene–environment interactions within the framework of common metabolic pathway of xenobiotic biotransformation determined by the enzymes. In particular, our recent studies (Yarosh et al ., , ) demonstrated an importance of gene–environment interactions analysis for better understanding the role of genes for xenobiotic‐metabolising enzymes in the pathogenesis of idiopathic infertility in men. This study was designed to investigate a comprehensive contribution of GSTM1 , GSTT1 and GSTP1 gene polymorphisms and cigarette smoking to the risk of idiopathic infertility in Russian men.…”
Section: Introductionmentioning
confidence: 99%
“…N-acetyltransferase (NAT2) is a xenobiotic metabolism enzyme that plays a role in the detoxification of toxicants of tobacco, such as hydrazines, aromatic amines, and arylamines. Hypoacetylated genotypes of NAT2 have been shown to be associated with a link between cigarette smoking and infertility, presumably by increasing ROS production and OS (odds ratio [OR]=1.71, 95% confidence interval [CI]=1.02~2.87, p=0.042) [ 145 ].…”
Section: Smoking-related Genetic Epigenetic and Molecular Alterationmentioning
confidence: 99%
“…Male infertility is a complex multifactorial disease, and in approximately half of the cases the aetiology is unknown (Krausz et al, 2015). It is widely believed that genetic factors may play an important role in male infertility (Sen et al, 2016;Yarosh et al, 2014;Zhang et al, 2015).…”
Section: Introductionmentioning
confidence: 99%