Synergism of cisplatin-oleanolic acid co-loaded hybrid nanoparticles on gastric carcinoma cells for enhanced apoptosis and reversed multidrug resistance

Li, Danyang; Cui, Ruixue; Xu, Shuning; Liu, Ying

doi:10.1080/10717544.2019.1710622

Cited by 27 publications

(12 citation statements)

References 38 publications

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“…The HNs were prepared from the membrane of MGC-803 cancer cells mixed with an aqueous solution of calcium carbonate (CC). The binding between calcium ions and the phosphates of the membrane led to the improved stability and targeting of the DDS [ 79 ]. Cisplatin is a commonly used chemotherapeutic agent involved in the formation of DNA adducts, which leads to DNA damage and apoptosis induction in cancer cells [ 80 ].…”

Section: Nanoformulations With Pentacyclic Triterpenoids In Anticamentioning

confidence: 99%

“…The drug release profile, in the case of both compounds, was pH-dependent, which is a crucial aspect in anticancer strategy due to the acidic extracellular pH in cancer tissue. Tumor-specific drug targeting and accumulation with the intensification of apoptosis processes and the withdrawal of MDR cells in both the in vitro and in vivo conditions of experiment were observed [ 79 ].…”

Section: Nanoformulations With Pentacyclic Triterpenoids In Anticamentioning

confidence: 99%

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Nanoformulations for Delivery of Pentacyclic Triterpenoids in Anticancer Therapies

2021

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The search for safe and effective anticancer therapies is one of the major challenges of the 21st century. The ineffective treatment of cancers, classified as civilization diseases, contributes to a decreased quality of life, health loss, and premature mortality in oncological patients. Many natural phytochemicals have anticancer potential. Pentacyclic triterpenoids, characterized by six- and five-membered ring structures, are one of the largest class of natural metabolites sourced from the plant kingdom. Among the known natural triterpenoids, we can distinguish lupane-, oleanane-, and ursane-types. Pentacyclic triterpenoids are known to have many biological activities, e.g., anti-inflammatory, antibacterial, hepatoprotective, immunomodulatory, antioxidant, and anticancer properties. Unfortunately, they are also characterized by poor water solubility and, hence, low bioavailability. These pharmacological properties may be improved by both introducing some modifications to their native structures and developing novel delivery systems based on the latest nanotechnological achievements. The development of nanocarrier-delivery systems is aimed at increasing the transport capacity of bioactive compounds by enhancing their solubility, bioavailability, stability in vivo and ensuring tumor-targeting while their toxicity and risk of side effects are significantly reduced. Nanocarriers may vary in sizes, constituents, shapes, and surface properties, all of which affect the ultimate efficacy and safety of a given anticancer therapy, as presented in this review. The presented results demonstrate the high antitumor potential of systems for delivery of pentacyclic triterpenoids.

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Section: Nanoformulations With Pentacyclic Triterpenoids In Anticamentioning

confidence: 99%

Section: Nanoformulations With Pentacyclic Triterpenoids In Anticamentioning

confidence: 99%

Nanoformulations for Delivery of Pentacyclic Triterpenoids in Anticancer Therapies

2021

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“…So, we precisely controlled the shapes and sizes of the NPs. In recent studies, the NPs sizes prepared were in the range of 100–600 nm 36 – 38 .…”

Section: Discussionmentioning

confidence: 99%

A new combination strategy to enhance apoptosis in cancer cells by using nanoparticles as biocompatible drug delivery carriers

Kucuksayan

Bozkurt

Yılmaz

et al. 2021

Sci Rep

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Some experimental and clinical studies have been conducted for the usage of chemotherapeutic drugs encapsulated into nanoparticles (NPs). However, no study has been conducted so far on the co-encapsulation of doxorubicin (Dox) and epoxomicin (Epo) into NPs as biocompatible drug delivery carriers. Therefore, we investigated if co-encapsulation of doxorubicin (Dox) and/or epoxomicin (Epo) into NPs enhance their anticancer efficiency and prevent drug resistance and toxicity to normal cells. We synthesized Dox and/or Epo loaded poly (lactic-co-glycolic acid) (PLGA) NPs using a multiple emulsion solvent evaporation technique and characterized them in terms of their particle size and stability, surface, molecular, thermal, encapsulation efficiency and in vitro release properties. We studied the effects of drug encapsulated NPs on cellular accumulation, intracellular drug levels, oxidative stress status, cellular viability, drug resistance, 20S proteasome activity, cytosolic Nuclear Factor Kappa B (NF-κB-p65), and apoptosis in breast cancer and normal cells. Our results proved that the nanoparticles we synthesized were thermally stable possessing higher encapsulation efficiency and particle stability. Thermal, morphological and molecular analyses demonstrated the presence of Dox and/or Epo within NPs, indicating that they were successfully loaded. Cell line assays proved that Dox and Epo loaded NPs were less cytotoxic to single-layer normal HUVECs than free Dox and Epo, suggesting that the NPs would be biocompatible drug delivery carriers. The apoptotic index of free Dox and Epo increased 50% through their encapsulation into NPs, proving combination strategy to enhance apoptosis in breast cancer cells. Our results demonstrated that the co-encapsulation of Dox and Epo within NPs would be a promising treatment strategy to overcome multidrug resistance and toxicity to normal tissues that can be studied in further in vivo and clinical studies in breast cancer.

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“…Some researchers have prepared calcium carbonate (CC) hybrid nanoparticles (HN) decorated with cancer cell membranes (CM) for the delivery of cisplatin (CDDP) and OA. The results showed that compared to free drugs alone or mono systems, it could enhance cell apoptosis and can reverse the cancer cells multidrug resistance [ 33 , 34 ].…”

Section: Pharmacological Effects Of Oa and Its Derivativesmentioning

confidence: 99%

Development and Evaluation of Oleanolic Acid Dosage Forms and Its Derivatives

Feng

Yang

Sun

et al. 2020

BioMed Research International

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Oleanolic acid is a pentacyclic triterpenoid compound that exists widely in medicinal herbs and other plants. Because of the extensive pharmacological activity, oleanolic acid has attracted more and more attention. However, the structural characteristics of oleanolic acid prevent it from being directly made into new drugs, which limits the application of oleanolic acid. Through the application of modern preparation techniques and methods, different oleanolic acid dosage forms and derivatives have been designed and synthesized. These techniques can improve the water solubility and bioavailability of oleanolic acid and lay a foundation for the new drug development. In this review, the recent progress in understanding the oleanolic acid dosage forms and its derivatives are discussed. Furthermore, these products were evaluated comprehensively from the perspective of characterization and pharmacokinetics, and this work may provide ideas and references for the development of oleanolic acid preparations.

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Synergism of cisplatin-oleanolic acid co-loaded hybrid nanoparticles on gastric carcinoma cells for enhanced apoptosis and reversed multidrug resistance

Cited by 27 publications

References 38 publications

Nanoformulations for Delivery of Pentacyclic Triterpenoids in Anticancer Therapies

Nanoformulations for Delivery of Pentacyclic Triterpenoids in Anticancer Therapies

A new combination strategy to enhance apoptosis in cancer cells by using nanoparticles as biocompatible drug delivery carriers

Development and Evaluation of Oleanolic Acid Dosage Forms and Its Derivatives

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