Synergism of Diet, Genetics, and Microbiome on Health

Abstract

“Human microbiome” includes a series of microscopic organisms that thrive, interact, and function with the human body. Studies related to gut microbiome reveal a very promising perspective of several diseases, though there are several knowledge gaps on their role in host-microbiome interactions, as well as potential therapeutic applications. Synergism of diet, genetics, and the microbiome on health is a complex interplay that has gained significant attention in recent years. This chapter will delve into the intricate relationships between diet, genetics, and the microbiome, exploring how they influence each other and ultimately shape human health. Certain microbial profiles are linked to diseases, but the causal relationships among environmental factors, diet, and genetics remain unclear. Dietary interventions may not always sufficiently modify microbial populations for optimal health. By unraveling these processes, we can develop targeted approaches to promote favorable gut microbial compositions and better overall health.