Synergism of dynamics of tetrahedral hydrogen bonds of liquid water

Kholmanskiy, Alexander

doi:10.1063/5.0052566

Cited by 6 publications

(15 citation statements)

References 43 publications

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“…Anomalies of its physical properties in the range from ~25 °C to ~ 42 °C are determined by the dynamics of hydrogen bonds in clusters of various compositions [64,65,66]. These features of the thermodynamics of water and its hydrogen bonds with the proteins of the conductive channels of cell membranes can underlie the differentiation of the mechanisms of operation of cold, heat and pain receptors in the epidermis.…”

Section: Discussionmentioning

confidence: 99%

Thermal stimulation of pressure phosphenes

Kholmanskiy¹,

Konyukhova²,

Minakhin³

2021

Preprint

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Synesthesia of vision and somatosensory is based on physiology of interconnection of neurons in different nuclei of thalamus or areas of cerebral cortex. Work studied effect on the intensity of pressure phosphenes (PP) of various methods of heating eyes and hands, as well as manual influence on cervical spine. Along with subjective assessments of the PP intensity, EEG and ECG were used for chronometry of bioelectrical activity of brain and heart. From analysis of frequency and amplitude spectra of EEG, it was concluded that mechanism of PP generation is dominated by processes of redistribution and recombination of charges in retinal and LGB layers. Stimulation of PP by heating hands was associated with convergence of LGB neurons and neurons of thalamus nuclei, which are responsible for thermoreception and are adjacent to LGB. Enhancement of effect of PP stimulation by heating hands in water and in sauna was explained by resonant mechanism of heat transfer from heated water to water of physiological fluids of epidermis and water associated with proteins of ion channels of thermoreceptor membranes. It was suggested that breakdown of water clusters in physiological fluids of epidermis at temperature above 42 C promotes to transformation of thermoreceptors into pain receptors.

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Section: Discussionmentioning

confidence: 99%

Thermal stimulation of pressure phosphenes

Kholmanskiy¹,

Konyukhova²,

Minakhin³

2021

Preprint

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“…In the general case, taking into account the known forms of the dependence of the properties of water on T β , the contribution of E T in the Arrhenius approximations (F A ) was expressed as a separate exponential [25, 28, 29]: …”

Section: Methodsmentioning

confidence: 99%

Thermo- and photoreceptors of eyes as regulators of circadian rhythm and glymphatic system

Kholmanskiy

2023

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The dynamics of hydrogen bonds in bulk and hydrated water affected the activation energies of temperature dependence of ion currents of voltage-dependent channels that regulate communication and trophic bonds in the neuropil of the cortical parenchyma. The physics of minimizing of isobaric heat capacity of water made it possible to explain stabilization and functional optimization of thermodynamics of eyeball fluids at 34.5 C and human brain during sleep at 36.5 C. At these temperatures, thermoreceptors of cornea and cells of ganglionic layer of the retina, through connections with suprachiasmatic nucleus and pineal gland, switch brain metabolism from daytime to nighttime modes. The phylogenesis of circadian rhythm was reflected in dependence of duration of nighttime sleep of mammals on diameter of eyeball, mass of pineal gland, and density of neurons in parenchyma of cortex. The activity of all nerves of eyeball led to division of nocturnal sleep into slow and fast phases. These phases correspond to two modes of glymphatic system - electrochemical and dynamic. The first is responsible for relaxation processes of synaptic plasticity and chemical neutralization of toxins with participation of water and melatonin. Rapid eye movement and an increase in cerebral blood flow in second mode increase water exchange in parenchyma and flush out toxins into venous system.

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“…Gap junctions provide movement of the depolarization front of myocardial cardiomyocytes at a speed of ~1 m/s. The dielectric relaxation time of water (τD), which characterizes the dynamics of the collective reorientation of molecules at 37°C, is ~7 ps [22,36,37], which ensures the propagation of EMV through the liquid media of the body and brain at a rate of C*.…”

Section: Electrophysics Of the Brain And Bloodmentioning

confidence: 99%

“…These values are close to Тw=34.5 °C, in the vicinity of which the isobaric heat capacity of water (CP) has a minimum [20,21]. It can be assumed that the following of the glymphatic system of the brain to the circadian rhythm is based on the features of the molecular physics of water in the vicinity of Tw [21][22][23], which are responsible for the mechanism of adaptation and stabilization of the brain temperature during wakefulness and sleep.…”

Section: Introduction 1the Uniqueness Of Water Physicsmentioning

confidence: 96%

Connection of brain glymphatic system with circadian rhythm

Kholmanskiy

2023

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To establish the relationship between the glymphatic system of the brain and the circadian rhythm, we analyzed the effect of anomalies in water thermodynamics on the dependence of the dynamic, electrical, and optical characteristics of physiological fluids on temperature. The dynamics of hydrogen bonds in bulk and hydrated water affected the activation energies of ion currents of voltage-dependent channels that regulate signaling and trophic bonds in the neuropil of the cortical parenchyma. The physics of minimizing the of the isobaric heat capacity of water made it possible to explain the stabilization and functional optimization of the thermodynamics of eyeball fluids at 34.5 C and the human brain during sleep at 36.5 C. At these temperatures, the thermoreceptors of the cornea and the cells of the ganglionic layer of the retina, through connections with the suprachiasmatic nucleus and the pineal gland, switch the circadian rhythm from daytime to nighttime. The phylogenesis of the circadian rhythm was reflected in the dependence of the duration of the nighttime sleep of mammals on the diameter of the eyeball and the mass of the pineal gland. The activity of all the nerves of the eyeball led to the division of the nocturnal brain metabolism into NREM and REM phases. These phases correspond to two modes of the glymphatic system - electrochemical and dynamic. The first is responsible for the relaxation processes of synaptic plasticity and chemical neutralization of toxins with the participation of water and melatonin. Rapid eye movement and an increase in cerebral blood flow in the second mode increase water exchange in the parenchyma and flush out toxins into the venous system. Electrophysics of clearance and conductivity of ionic and water channels of membranes of blood vessels and astrocytes modulate oscillations of polarization potentials of water dipole domains in parietal plasma layers of arterioles and capillaries.

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Synergism of dynamics of tetrahedral hydrogen bonds of liquid water

Cited by 6 publications

References 43 publications

Thermal stimulation of pressure phosphenes

Thermal stimulation of pressure phosphenes

Thermo- and photoreceptors of eyes as regulators of circadian rhythm and glymphatic system

Connection of brain glymphatic system with circadian rhythm

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