Dioscorea bulbifera L. and leri water have the potential to control dry wood termites because they contain several compounds (flavonoids, alkaloids, chlorine, and tannins) that can eradicate termites and damage insect body cells. This study aims to determine the effectiveness of the combination of D. bulbifera extract and leri water against Cryptotermes cynocephalus Light. The completely randomized design investigation employed three replications and nine treatments. In this study, only one test, namely the contact poison test, was applied. A variety of concentrations, a D. bulbifera extract source, and leri water were used as the treatment in this investigation. Termite mortality, test weight reduction, and the degree of damage were the parameters that were measured. The treatment significantly decreased the test's weight and the degree of damage. Still, it had no statistically significant impact on mortality, according to the DMRT test, at a substantial level of 5%. The results showed that the best mortality, test weight reduction, and degree of damage were found in the combination of stem (50%): leri water (50%), which were 62.22% (equal to corrected mortality of 45.16%), 8.34%, 16.47%, respectively. The combination of these extracts efficiently inhibits dry wood termites, according to this result.