Synergistic Activation of Interleukin-8 Gene Transcription by All-trans-retinoic Acid and Tumor Necrosis Factor-α Involves the Transcription Factor NF-κB

Harant, Hanna; Martin, Rainer de; Andrew, Penelope; Foglar, Elisabeth; Dittrich, Christian; Lindley, I. J. D.

doi:10.1074/jbc.271.43.26954

Cited by 107 publications

(85 citation statements)

References 41 publications

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“…in ICD models in previous in vivo and in vitro studies, although most of the studies were performed in the early induction stage of irritant dermatitis. TNF-α and IL-8 were also reported to be up-regulated in retinoid dermatitis [18][19][20] .…”

Section: Discussionmentioning

confidence: 99%

Epidermal Hyperplasia and Elevated HB-EGF are More Prominent in Retinoid Dermatitis Compared with Irritant Contact Dermatitis Induced by Benzalkonium Chloride

et al. 2010

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Background: 'Retinoid dermatitis' is a retinoid-induced irritant contact dermatitis (ICD). The mechanism of retinoid dermatitis may be different from that of other ICDs. However, it remains uncertain how topical retinoid induce ICD. Objective: We compared several aspects of contact dermatitis induced by topical retinol and benzalkonium chloride (BKC) on hairless mice skin. Methods: 2% retinol or 2.5% BKC was applied to hairless mice and transepidermal water loss (TEWL), ear thickness, histologic and immunohistochemical findings were compared. We also compared mRNA expression of inflammatory cytokines, epidermal differential markers, cyclooxygenases (COXs) and heparin binding epidermal growth factor like growth factor (HB-EGF). Results: Topical application of 2% retinol and 2.5% BKC increased TEWL and ear thickness in similar intensity. Epidermal hyperplasia was more prominent in retinol treated skin. Proliferating cell nuclear antigen, involucrin and loricrin expression were higher in retinol-treated skin than in BKC-treated skin. Filaggrin, however, was more expressed in BKC-treated skin. The mRNA expression of IL-8, TNF-α, COX-2, involucrin, loricrin and filaggrin were increased in both retinol-and BKC-treated skin in similar intensity. HB-EGF was more significantly increased in retinol-treated skin. Conclusion: Elevated HB-EGF and epidermal hyperplasia are more prominent features of retinoid dermatitis than in BKC-induced ICD. (Ann Dermatol 22(3) 290∼299,

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Section: Discussionmentioning

confidence: 99%

Epidermal Hyperplasia and Elevated HB-EGF are More Prominent in Retinoid Dermatitis Compared with Irritant Contact Dermatitis Induced by Benzalkonium Chloride

et al. 2010

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“…For example, up-regulation of proinflammatory mediators by RA such as IL-1 g , IL-8 and TNF- § has been reported previously [45][46][47], and these cytokines are also substantially promoted by ATRA in human mast cells (Babina et al, manuscript in preparation). Since IL-1 g and TNF- § are known to up-regulate ICAM-1 expression by EC, downregulation of CD11 subunits by monocytes might also represent a compensatory regulatory mechanism, preventing exaggerated adhesion of monocytes to the inflamed endothelium.…”

Section: Discussionmentioning

confidence: 99%

All‐trans retinoic acid down‐regulates expression and function of β₂ integrins by human monocytes: opposite effects on monocytic cell lines

Babina

Henz

2003

Eur J Immunol

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All-trans retinoic acid (ATRA) plays an important role in the differentiation of malignant myeloid cells but its effects on primary leukocytes have been poorly investigated. We report here that ATRA negatively affects expression and function of leukocyte integrins that play a key role in monocyte adhesive interactions. As evidenced by flow cytometry, ATRA (at 1 ? M) clearly and donor-independently suppressed the expression of all integrin chains investigated (CD11a, CD11b, CD11c, and CD18), most strikingly of CD11a. Down-regulation was detectable after 24 and maximal after 72-96 h. Reverse transcription-PCR analysis revealed diminished steady-state concentrations of § specific transcripts but not of the common g chain, suggesting that heterodimer expression was predominantly regulated through § chains. Results obtained with blood-derived monocytes were in sharp contrast to those for the leukemic cell lines THP-1 and U937, both of which showed marked increase in all integrin subunits in response to ATRA. ATRA-pretreated monocytes displayed significantly diminished g 2 integrin-dependent homotypic aggregation, and adhesion to stimulated endothelial cells (EC), while ATRA-pretreated monocytic cell lines showed the opposite behavior displaying markedly enhanced aggregation and CD18-mediated adhesion to EC. Therefore, the level of leukocyte integrins was obviously a decisive factor for these adhesive interactions irrespective of the cellular source. Collectively, our data indicate a striking difference between leukemic cell lines and normal hematopoietic cells with regard to ATRA responsiveness. By acting on key adhesive structures of normal leukocytes, ATRA mediates processes that may be of substantially broad range applying to inflammation and immunity in addition to differentiation and proliferation.

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“…Nuclear extracts from cells were prepared as described previously with minor changes (13,14). Briefly, cells were seeded in a 100-mm tissue culture dish and allowed to attach overnight.…”

Section: Nuclear Protein Extractionmentioning

confidence: 99%

During Human Melanoma Progression AP‐1 Binding Pairs are Altered with Loss of c‐Jun In Vitro

Yang

McNulty

Meyskens

2004

Pigment Cell Research

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We demonstrated previously that c‐Jun, JunB and c‐Fos RNA were dysregulated in metastatic melanoma cells compared with normal human melanocytes. The purpose of this study was to evaluate the distribution in composition of AP‐1 dimers in human melanoma pathogenesis. We investigated AP‐1 dimer pairing in radial growth phase‐like (RGP) (w3211) and vertical growth phase‐like (VGP) (w1205) human melanoma cells and metastatic cell lines (cloned from patients, c83‐2c, c81‐46A, A375, respectively) compared with melanocytes using electrophoretic mobility shift assay (EMSA), Western blot and transfection analyses. There are progressive variations in AP‐1 composition in different melanoma cell lines compared with normal melanocytes, in which c‐Jun, JunD and FosB were involved in AP‐1 complexes. In w3211, c‐Jun, JunD and Fra‐1 were involved in AP‐1 binding, while in w1205, overall AP‐1 binding activity was decreased significantly and supershift binding was detected only with JunD antibodies. In metastatic c81‐46A and A375 cells, only JunD was involved in AP‐1 binding activity, but in a third (c83‐2c) c‐Jun, JunD and Fra‐1 were present. Western blot evaluation detected c‐Jun in melanocytes and w3211, but this component was decreased significantly or was not detectable in w1205, c81‐46A and A375 cells. In contrast, JunD protein was elevated in c81‐46A and c83‐2c cells compared with melanocytes and RGP and VGP cell lines. Normal melanocytes and c83‐2c cells (which have c‐Jun involved in AP‐1 binding), transfected with c‐Jun antisense and treated with cisplatin, showed higher viability compared with untransfected cells, while in c81‐46A cells (in which only JunD is detectable) no change in cell viability was observed following treatment with cisplatin and c‐jun antisense transfection. A dominant‐negative c‐Jun mutant (TAM67) significantly increased the soft agar colony formation of w3211 and c83‐2c cells. These results suggest that components of AP‐1, especially c‐Jun, may offer a new target for the prevention or treatment of human melanoma progression.

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Synergistic Activation of Interleukin-8 Gene Transcription by All-trans-retinoic Acid and Tumor Necrosis Factor-α Involves the Transcription Factor NF-κB

Abstract: Induction of interleukin-8 (IL-8

Cited by 107 publications

References 41 publications

Epidermal Hyperplasia and Elevated HB-EGF are More Prominent in Retinoid Dermatitis Compared with Irritant Contact Dermatitis Induced by Benzalkonium Chloride

Epidermal Hyperplasia and Elevated HB-EGF are More Prominent in Retinoid Dermatitis Compared with Irritant Contact Dermatitis Induced by Benzalkonium Chloride

All‐trans retinoic acid down‐regulates expression and function of β₂ integrins by human monocytes: opposite effects on monocytic cell lines

During Human Melanoma Progression AP‐1 Binding Pairs are Altered with Loss of c‐Jun In Vitro

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Synergistic Activation of Interleukin-8 Gene Transcription by All-trans-retinoic Acid and Tumor Necrosis Factor-α Involves the Transcription Factor NF-κB

Abstract: Induction of interleukin-8 (IL-8

Cited by 107 publications

References 41 publications

Epidermal Hyperplasia and Elevated HB-EGF are More Prominent in Retinoid Dermatitis Compared with Irritant Contact Dermatitis Induced by Benzalkonium Chloride

Epidermal Hyperplasia and Elevated HB-EGF are More Prominent in Retinoid Dermatitis Compared with Irritant Contact Dermatitis Induced by Benzalkonium Chloride

All‐trans retinoic acid down‐regulates expression and function of β2 integrins by human monocytes: opposite effects on monocytic cell lines

During Human Melanoma Progression AP‐1 Binding Pairs are Altered with Loss of c‐Jun In Vitro

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All‐trans retinoic acid down‐regulates expression and function of β₂ integrins by human monocytes: opposite effects on monocytic cell lines