Synergistic activity of crocin and crocin loaded in niosomes alone and in combination with fluconazole against Candida albicans isolates: In vitro and in silico study

Norozipor, Sara; Bamorovat, Mehdi; Ayatollahi Mosavi, Seyyed Amin; Salarkia, Ehsan; Hadizadeh, Sanaz; Sharifi, Fatemeh; Karamoozian, Ali; Ranjbar, Mehdi; Agha Kuchak Afshari, Setareh

doi:10.1016/j.mycmed.2024.101478

Journal of Medical Mycology

2024

DOI: 10.1016/j.mycmed.2024.101478

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Synergistic activity of crocin and crocin loaded in niosomes alone and in combination with fluconazole against Candida albicans isolates: In vitro and in silico study

Sara Norozipor,

Mehdi Bamorovat,

Seyyed Amin Ayatollahi Mosavi

et al.

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Investigation of Potent Antifungal Metabolites from Marine Streptomyces bacillaris STR2 (MK045300) from Western Algeria

Boublenza,

Dergal,

Belyagoubi

et al. 2024

Bacteria

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Fungal infections significantly threaten public health, and many strains are resistant to antifungal drugs. Marine Actinobacteria have been identified as the generators of powerful bioactive compounds with antifungal activity and can be used to address this issue. In this context, strains of Actinomycetes were isolated from the marine area of Rachgoun Island, located in western Algeria. The isolates were phenotypically and genetically characterized. The most potent antifungal isolate was selected, and its crude extract was purified and characterized by the GC/MS method. The results revealed that the STR2 strain showed the strongest activity against at least one target fungal species tested on a panel of fungal pathogens, including Candida albicans, Aspergillus fumigatus, Aspergillus niger, and Fusarium oxysporum. The molecular assignment of the STR2 strain based on the 16S rRNA gene positioned this isolate as a Streptomyces bacillaris species. The presence of safranal (2,3-dihydro-2,2,6-trimethylbenzaldehyde) in the crude chloroform extract of Streptomyces bacillaris STR2 strain was discovered for the first time in bacteria using chromatographic analysis of its TLC fractions. Moreover, certain molecules of biotechnological interest, such as phenols, 1,3-dioxolane, and phthalate derivatives, were also identified. This study highlights the potential of marine actinomycetes to produce structurally unique natural compounds with antifungal activity.

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Investigation of Potent Antifungal Metabolites from Marine Streptomyces bacillaris STR2 (MK045300) from Western Algeria

Boublenza,

Dergal,

Belyagoubi

et al. 2024

Bacteria

View full text Add to dashboard Cite

show abstract

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Synergistic activity of crocin and crocin loaded in niosomes alone and in combination with fluconazole against Candida albicans isolates: In vitro and in silico study

Cited by 1 publication

References 26 publications

Investigation of Potent Antifungal Metabolites from Marine Streptomyces bacillaris STR2 (MK045300) from Western Algeria

Investigation of Potent Antifungal Metabolites from Marine Streptomyces bacillaris STR2 (MK045300) from Western Algeria

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