Synergistic anti-cancer effects of NIR-light responsive nanotherapeutics for chemo-photothermal therapy and photothermal immunotherapy: A combined therapeutic approach

Karthikeyan, Laxmanan; Vivek, Raju

doi:10.1016/j.adcanc.2022.100044

Cited by 21 publications

(17 citation statements)

References 154 publications

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“…For this experiment, to one million cells in a pellet simulating a small tumor, the materials, either the TR-CuFeS 2 -DOXO (3.6 μg DOXO/mL/40 μgCu/ mL) or the TR-CuFeS 2 NPs (at 40 μgCu/mL), were added and exposed to PTT under an 808 nm laser (Figure 5B and see setup in Figure S10A and heating profiles in Figure S10B,C). By re-culturing the cells post-PTT exposure, the cell viability was monitored at different time points (24,48, and 72 h) and compared to that of nontreated control U87/A431 cells that did not undergo any treatment (Ctrl) or to the viability of those cell samples that did receive the NPs material but were kept at 37 °C with no PTT exposure. The viability results showed that the combined effect of PTT and DOXO release by TR-CuFeS 2 -DOXO NPs caused the highest cytotoxicity against both tumoral cells (Figure 5C−D).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

CuFeS₂ Nanoparticles Functionalized with a Thermoresponsive Polymer for Photothermia and Externally Controlled Drug Delivery

Conteh

Nucci

Fernández‐Cabada

et al. 2023

ACS Appl. Mater. Interfaces

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CuFeS2 chalcopyrite nanoparticles (NPs) can generate heat under exposure to near-infrared laser irradiation. Here, we develop a protocol to decorate the surface of CuFeS2 NPs (13 nm) with a thermoresponsive (TR) polymer based on poly(ethylene glycol methacrylate) to combine heat-mediated drug delivery and photothermal heat damage. The resulting TR-CuFeS2 NPs feature a small hydrodynamic size (∼75 nm), along with high colloidal stability and a TR transition temperature of 41 °C in physiological conditions. Remarkably, TR-CuFeS2 NPs, when exposed to a laser beam (in the range of 0.5 and 1.5 W/cm2) at NP concentrations as low as 40–50 μg Cu/mL, exhibit a high heating performance with a rise in the solution temperature to hyperthermia therapeutic values (42–45 °C). Furthermore, TR-CuFeS2 NPs worked as nanocarriers, being able to load an appreciable amount of doxorubicin (90 μg DOXO/mg Cu), a chemotherapeutic agent whose release could then be triggered by exposing the NPs to a laser beam (through which a hyperthermia temperature above 42 °C could be reached). In an in vitro study performed on U87 human glioblastoma cells, bare TR-CuFeS2 NPs were proven to be nontoxic at a Cu concentration up to 40 μg/mL, while at the same low dose, the drug-loaded TR-CuFeS2-DOXO NPs displayed synergistic cytotoxic effects due to the combination of direct heat damage and DOXO chemotherapy, under photo-irradiation by a 808 nm laser (1.2 W/cm2). Finally, under a 808 nm laser, the TR-CuFeS2 NPs generated a tunable amount of reactive oxygen species depending on the applied power density and NP concentration.

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Section: ■ Results and Discussionmentioning

confidence: 99%

CuFeS₂ Nanoparticles Functionalized with a Thermoresponsive Polymer for Photothermia and Externally Controlled Drug Delivery

Conteh

Nucci

Fernández‐Cabada

et al. 2023

ACS Appl. Mater. Interfaces

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“…Some studies have shown synergistic effectiveness of PDT and PTT with cancer immunotherapy in several cancer models. Photosensitizers and immunomodulators were anchored to inorganic nanomaterials, causing increased cancer cell targeting and death. , …”

Section: Principle Of Actionmentioning

confidence: 99%

Light Conversion Nanomaterials for Wireless Phototherapy

Sun

Teo

et al. 2023

Acc. Chem. Res.

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“…PTT frequently necessitates the tumor to achieve higher temperatures (>50 °C), and a temperature gradient will occur so that the edge of the tumor will reach therapeutic temperatures. However, efficient ablation of the tumors demands the elimination of every cancer cell 7 , 8 .…”

Section: Introductionmentioning

confidence: 99%

“…They are carbon nanotubes, quantum dots, liposome NPs, polymer NPs and metallic NPs. Among the metal-based NPs, gold NPs (AuNP) have been the most evolved and sped up towards clinical preliminaries 8 , 16 .…”

Section: Introductionmentioning

confidence: 99%

Ultra-small NIR-Responsive Nanotheranostic Agent for Targeted Photothermal Ablation Induced Damage-Associated Molecular Patterns (DAMPs) from Post-PTT of Tumor Cells Activate Immunogenic Cell Death

Sobhana¹,

Sarathy²,

Karthikeyan³

et al. 2023

Nanotheranostics

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Theranostic nanoparticles (TNPs) is an efficient avenue that culminates both diagnosis and therapy into cancer treatment. Herein, we have formulated a theranostic nanocomposite (NC) with CuS being the ultra-small core component. To ensure stability to the NC, PEI was added which is a vital anchoring group polymer, especially on sulfide surfaces, and adds quality by being a better stabilizer and reducing agent. Additionally, to add stability, specificity, and added photothermal efficiency to the fabricated NC. In addition, encapsulation of indocyanine green (ICG), an efficient NIR absorber, and Folic acid (FA) were conjugated systematically, characterized, and analyzed for photo-stability. The photothermal conversion efficiency of the novel NC (CuS-PEI-ICG-FA) was analyzed at 808 nm, where the NC efficiently converted light energy to heat energy. The NC was also tested for hemocompatibility to clarify and also determined biocompatibility. Surprisingly, damage-associated molecular patterns (DAMPs) from post-PTT of tumor cells activate immunogenic cell death (ICD) for tumor-specific immune responses. The deserving photothermal performance and photo-stability makes the NC an ideal platform for photoacoustic imaging (PAI). A superior contrast was observed for PAI in a concentration-dependent manner enhancing the level of penetration into tissues, thereby better imaging. On account of this study, the newly formulated NC could be utilized as a "nanotheranostic" designed for therapeutic and image diagnostic agent of cancer biomedical applications.

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Synergistic anti-cancer effects of NIR-light responsive nanotherapeutics for chemo-photothermal therapy and photothermal immunotherapy: A combined therapeutic approach

Cited by 21 publications

References 154 publications

CuFeS₂ Nanoparticles Functionalized with a Thermoresponsive Polymer for Photothermia and Externally Controlled Drug Delivery

CuFeS₂ Nanoparticles Functionalized with a Thermoresponsive Polymer for Photothermia and Externally Controlled Drug Delivery

Light Conversion Nanomaterials for Wireless Phototherapy

Ultra-small NIR-Responsive Nanotheranostic Agent for Targeted Photothermal Ablation Induced Damage-Associated Molecular Patterns (DAMPs) from Post-PTT of Tumor Cells Activate Immunogenic Cell Death

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Synergistic anti-cancer effects of NIR-light responsive nanotherapeutics for chemo-photothermal therapy and photothermal immunotherapy: A combined therapeutic approach

Cited by 21 publications

References 154 publications

CuFeS2 Nanoparticles Functionalized with a Thermoresponsive Polymer for Photothermia and Externally Controlled Drug Delivery

CuFeS2 Nanoparticles Functionalized with a Thermoresponsive Polymer for Photothermia and Externally Controlled Drug Delivery

Light Conversion Nanomaterials for Wireless Phototherapy

Ultra-small NIR-Responsive Nanotheranostic Agent for Targeted Photothermal Ablation Induced Damage-Associated Molecular Patterns (DAMPs) from Post-PTT of Tumor Cells Activate Immunogenic Cell Death

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CuFeS₂ Nanoparticles Functionalized with a Thermoresponsive Polymer for Photothermia and Externally Controlled Drug Delivery

CuFeS₂ Nanoparticles Functionalized with a Thermoresponsive Polymer for Photothermia and Externally Controlled Drug Delivery