Synergistic anticancer action of quercetin and curcumin against triple‐negative breast cancer cell lines

Kundur, Sai; Prayag, Amrita; Selvakumar, Priyanga; Nguyen, Hung Thanh; McKee, Lloyd; Cruz, Clairissa; Srinivasan, Asha; Shoyele, Sunday; Lakshmikuttyamma, Ashakumary

doi:10.1002/jcp.27761

Cited by 95 publications

(67 citation statements)

References 67 publications

(142 reference statements)

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“…Meanwhile, a correlation between β-catenin and HAT has been reported in other cancers [100]. Recently, we showed that quercetin enhances epigenetically silenced BRCA1 expression in TNBC [102]. Furthermore, our study revealed that the combined effect of quercetin and curcumin enhanced BRCA1 expression synergistically and the BRCA1 promoter histone H3K9 acetylation was significantly increased with the combined treatment in a TNBC cell line (MDA-MB-231) [10].…”

Section: Quercetin Modulates Brca1 Expression Levelsupporting

confidence: 57%

Flavonoids and Other Polyphenols Act as Epigenetic Modifiers in Breast Cancer

et al. 2020

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Breast cancer is a common cancer that occurs due to different epigenetic alterations and genetic mutations. Various epidemiological studies have demonstrated an inverse correlation between breast cancer incidence and flavonoid intake. The anti-cancer action of flavonoids, a class of polyphenolic compounds that are present in plants, as secondary metabolites has been a major topic of research for many years. Our review analysis demonstrates that flavonoids exhibit anti-cancer activity against breast cancer occurring in different ethnic populations. Breast cancer subtype and menopausal status are the key factors in inducing the flavonoid’s anti-cancer action in breast cancer. The dose is another key factor, with research showing that approximately 10 mg/day of isoflavones is required to inhibit breast cancer occurrence. In addition, flavonoids also influence the epigenetic machinery in breast cancer, with research demonstrating that epigallocatechin, genistein, and resveratrol all inhibited DNA methyltransferase and altered chromatin modification in breast cancer. These flavonoids can induce the expression of different tumor suppressor genes that may contribute to decreasing breast cancer progression and metastasis. Additional studies are required to confirm the contribution of epigenetic modifications by flavonoids to breast cancer prevention.

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Section: Quercetin Modulates Brca1 Expression Levelsupporting

confidence: 57%

Flavonoids and Other Polyphenols Act as Epigenetic Modifiers in Breast Cancer

et al. 2020

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“…It has been reported that quercetin blocks the progression of diverse human tumors, such as oral cancer, breast cancer, and NSCLC . In this work, the function of quercetin in reversing the radioresistance of NSCLC cells was studied.…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that quercetin blocks the progression of diverse human tumors, such as oral cancer, breast cancer, and NSCLC. 14,27,28 In this work, the function of quercetin in reversing the radioresistance of NSCLC cells was studied. It was demonstrated for the first time that quercetin exerts an anti-cancer effect in vitro via modulating miR-16-5p and WEE1 expressions.…”

Section: Discussionmentioning

confidence: 99%

Quercetin radiosensitizes non‐small cell lung cancer cells through the regulation of miR‐16‐5p/WEE1 axis

et al. 2020

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Background Quercetin, a widely distributed bioflavonoid, plays a role in combating diverse human cancers including non‐small cell lung cancer (NSCLC). However, the role of quercetin in reversing the radioresistance of NSCLC cells and its underlying mechanism are far from being elucidated. Method Radiation‐resistant NSCLC cell lines were established. Quantitative real‐time PCR (qRT‐PCR) was used to detect the expression of miR‐16‐5p and WEE1 G2 checkpoint kinase (WEE1) mRNA in radiation‐resistant cells. After being treated with different concentrations of quercetin and different doses of X‐ray, cell proliferation and apoptosis were monitored by CCK‐8 assay, colony formation assay, and flow cytometry, respectively. Ultimately, the targeting relationship between miR‐16‐5p and WEE1 was verified via a dual fluorescent reporter gene assay. Results The expression of miR‐16‐5p was down‐regulated in radiation‐resistant cells, while the expression of WEE1 was up‐regulated. Quercetin enhanced the radiosensitivity of NSCLC cells in a dose‐ and time‐dependent manner. Furthermore, quercetin treatment increased the expression of miR‐16‐5p and decreased the expression of WEE1. The function of quercetin was reversed by miR‐16‐5p inhibitors or the transfection of WEE1 overexpressing plasmids. Conclusion In conclusion, quercetin enhanced the radiosensitivity of NSCLC cells via modulating the expression of miR‐16‐5p and WEE1.

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“…Therefore, T1 inhibited cancer growth in several BC cell lines (MCF-7, MDA-MB-231, SKBR3, MDA-MB-453) in vitro, at least partially by affecting the function of this gene [122]. Triple-negative breast cancer (TNBC), which represents an aggressive BC subtype with poor prognosis, is highly associated with mutations of tumorsupressor BRCA1 [125][126][127]. However, quercetin and curcumin (CUR) dose-dependently inhibited cell survival and migration of TNBC cell lines in vitro via modulation of BRCA1 expression.…”

Section: Impact Of Phytochemicals On Histone Chemical Modifications Imentioning

confidence: 99%

“…However, quercetin and curcumin (CUR) dose-dependently inhibited cell survival and migration of TNBC cell lines in vitro via modulation of BRCA1 expression. The authors of the study concluded that these synergistically acting natural compounds repressed the silencing of BRCA1 via an increase in H3 lysine acetylation of its promoter [127]. Moreover, anticancer efficacy of crystal lapiferin derived from the traditional Algerian plant, Ferulaves ceritensis, was evaluated in human BC cells.…”

Section: Impact Of Phytochemicals On Histone Chemical Modifications Imentioning

confidence: 99%

Fluctuations of Histone Chemical Modifications in Breast, Prostate, and Colorectal Cancer: An Implication of Phytochemicals as Defenders of Chromatin Equilibrium

et al. 2019

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Natural substances of plant origin exert health beneficiary efficacy due to the content of various phytochemicals. Significant anticancer abilities of natural compounds are mediated via various processes such as regulation of a cell’s epigenome. The potential antineoplastic activity of plant natural substances mediated by their action on posttranslational histone modifications (PHMs) is currently a highly evaluated area of cancer research. PHMs play an important role in maintaining chromatin structure and regulating gene expression. Aberrations in PHMs are directly linked to the process of carcinogenesis in cancer such as breast (BC), prostate (PC), and colorectal (CRC) cancer, common malignant diseases in terms of incidence and mortality among both men and women. This review summarizes the effects of plant phytochemicals (isolated or mixtures) on cancer-associated PHMs (mainly modulation of acetylation and methylation) resulting in alterations of chromatin structure that are related to the regulation of transcription activity of specific oncogenes, which are crucial in the development of BC, PC, and CRC. Significant effectiveness of natural compounds in the modulation of aberrant PHMs were confirmed by a number of in vitro or in vivo studies in preclinical cancer research. However, evidence concerning PHMs-modulating abilities of plant-based natural substances in clinical trials is insufficient.

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Synergistic anticancer action of quercetin and curcumin against triple‐negative breast cancer cell lines

Cited by 95 publications

References 67 publications

Flavonoids and Other Polyphenols Act as Epigenetic Modifiers in Breast Cancer

Flavonoids and Other Polyphenols Act as Epigenetic Modifiers in Breast Cancer

Quercetin radiosensitizes non‐small cell lung cancer cells through the regulation of miR‐16‐5p/WEE1 axis

Fluctuations of Histone Chemical Modifications in Breast, Prostate, and Colorectal Cancer: An Implication of Phytochemicals as Defenders of Chromatin Equilibrium

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