Synergistic antidiabetic activities of zinc, cyclo (His-Pro), and arachidonic acid

Song, Min-Ae; Rosenthal, Mark J.; Hong, Suk-Jin; Harris, Diane M.; Hwang, In-Kyung; Yip, Ian; Golub, Michael S.; Ament, Marvin E.; Go, Vay Liang W.

doi:10.1053/meta.2001.19427

Cited by 41 publications

(51 citation statements)

References 49 publications

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“…[25][26][27][28][29] The MC-induced hypoglycemia may be due to a mixture of steroidal saponins called charantins, insulin-like peptides and alkaloids. 30) Day et al 4) have reported that these chemicals are divided into two categories with different time-dependent effects; one is present in the aqueous solution and the residue after alkaline chloroform extraction exerted a rapid hypoglycemic effect; the other is present in the acidic wash of chloroform extraction, which exerted a slow antihyperglycemic effect.…”

Section: Discussionmentioning

confidence: 99%

Slow Acting Protein Extract from Fruit Pulp of Momordica charantia with Insulin Secretagogue and Insulinomimetic Activities

Yibchok-anun

Adisakwattana

Yao

et al. 2006

Biological & Pharmaceutical Bulletin

109

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The protein from Thai bitter gourd (Momordica charantia) fruit pulp was extracted and studied for its hypoglycemic effect. Subcutaneous administration of the protein extract (5, 10 mg/kg) significantly and markedly decreased plasma glucose concentrations in both normal and streptozotocin-induced diabetic rats in a dose-dependent manner. The onset of the protein extract-induced antihyperglycemia/hypoglycemia was observed at 4 and 6 h in diabetic and normal rats, respectively. This protein extract also raised plasma insulin concentrations by 2 fold 4 h following subcutaneous administration. In perfused rat pancreas, the protein extract (10 m mg/ml) increased insulin secretion, but not glucagon secretion. The increase in insulin secretion was apparent within 5 min of administration and was persistent during 30 min of administration. Furthermore, the protein extract enhanced glucose uptake into C 2 C 12 myocytes and 3T3-L1 adipocytes. Time course experiments performed in rat adipocytes revealed that M. charantia protein extract significantly increased glucose uptake after 4 and 6 h of incubation. Thus, the M. charantia protein extract, a slow acting chemical, exerted both insulin secretagogue and insulinomimetic activities to lower blood glucose concentrations in vivo.

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Section: Discussionmentioning

confidence: 99%

Slow Acting Protein Extract from Fruit Pulp of Momordica charantia with Insulin Secretagogue and Insulinomimetic Activities

Yibchok-anun

Adisakwattana

Yao

et al. 2006

Biological & Pharmaceutical Bulletin

109

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“…In previous studies, we demonstrated that treatment of streptozotocin-induced diabetic rats with zinc plus CHP (ZC) significantly improved indices of diabetes, such as hyperglycemia (1,2). This diabetic rat model mimics human Type I diabetes mellitus (IDDM), a genetic disorder of pancreatic ␤-cell destruction evoked by certain environmental factors.…”

mentioning

confidence: 94%

Anti-Hyperglycemic Activity of Zinc Plus Cyclo (His-Pro) in Genetically Diabetic Goto-Kakizaki and Aged Rats

Song

Hwang²,

Rosenthal³

et al. 2003

Exp Biol Med (Maywood)

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We previously reported that treatment of streptozotocln-Induced diabetic rats with zinc plus cyclo (his-pro) (CHP) decreased fed blood glucose levels and water Intake. The present study was conducted to examine the dose-dependent, acute, and chronic treatment effects of CHP on oral glucose tolerance (OGT),fed blood glucose levels, water Intake, and plasma Insulin levels In young and aged Sprague-Dawley (S-D) rats, nondiabetic Wlstar rats, and genetically diabetic Goto-Kaklzakl (G-K) rats. Acute gastric gavage of 10 mg zinc pius 1.0 mg CHP/kg body weight significantly Improved OGT In 4-and ta-month-old nondiabetic SoD rats and In z-month-etd diabetic G-K rats. Young SoD and G-K rats returned to pretreatment OGT values 1 week after acute gavage of zinc plus CHP (ZC), but Improved OGT values persisted for at least 1 week after gavage In aged SoD rats. OGT values and fed blood glucose decreased to the greatest extent among other treatments when G-K rats were given free access to drinking water containing 1.0 to 1.5 mg CHP/l plus 10 mg zlnc/l for 2 weeks. Although food and water Intake showed a tendency to decrease, no statistically significant differences were observed In young G-K rats. Plasma Insulin levels and blood glucose levels In both normal and diabetic G-K rats decreased with 2-week treatment with ZC. To test the direct effects of ZC on muscle tissue, we observed the effect of various doses of ZC on normal and G-K rat muscle slices. The optimal level of CHP alone for maximal muscle glucose uptake In muscle slices from normal rats was 10 1J9/ml and 5.0 lJg!ml In G-K rats, and ZC stimulated glucose uptake. However, no statistically significant difference was demonstrated between normal and G-K rat tissues In this stUdy. These results indicate that oral Intake of an optimal dose of ZC stimulates

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“…또한 CHP는 뇌하수체로부터 prolactin의 분비를 저해하며 [11], 알콜에 의한 부작용을 완화하고 [12], 또한 식사욕구를 완화하여 비만을 예방할 수 있는 효과를 지니고 있다. 동물과 사람의 당뇨 유발 시 혈청 내의 TRH 수준이 감소되어지는 것을 확인하였으며, TRH는 인슐린 분비를 촉진하며, 조직 내에서는 뇌와 전립선에서 가장 높은 함량을 보이고 있다 [13].…”

Section: 서론unclassified

“…Diketopiperazines는 dipeptide esters 나 dipeptides로부터 쉽게 형성되고 dipeptide esters와 amides 또한 화학적 열처리를 통해 diketopiperazine으로 쉽게 고리 화된다 [14,35]. 식품 중의 CHP는 대부분 식품 가공 중에 단 백질 가수분해의 열처리 과정에서 생성되는 것으로 생각되고 있으며 [13], 실제로 단백질 가수분해물의 제조 공정 동안의 열처리 정도에 따라 CHP 함유량이 달라진다 [14]. 본 연구 에서 His-Pro 또는 Pro-His dipeptide를 다량 함유한 대두는 특정 균주에 의한 발효 과정에서 효소적 가수분해와 열처리 를 통해 고용량의 CHP를 형성하는 것으로 추정된다.…”

Section: Strain 1 Strainunclassified

Enhancement of Cyclo-His-Pro (CHP) Content from Soybean Fermented with Bacillus amyloliquefaciens CHP-12 and Its Anti-diabetic Effect

나경수¹,

최장원²

2011

KSBB Journal

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1) To enhance cyclo-His-Pro (CHP) content, soybean hydrolysate was obtained using the strains isolated from Chungkukjang and further purified by various purification steps. First, twenty two strains were screened from Chungkukjang containing high level of CHP. Among them, the strain No. 12, which showed higher productivity of CHP from soybean ferment and have homologous sequence with 16S rDNA of Bacillus amyloliquefaciens, was named B. amyloliquefaciens CHP-12. Through various purification processes, CHP was concentrated from soybean ferment using ultrafiltration, which showed the best efficiency of CHP production, with the yield (71.3%) and CHP content (2.14 mg/g). Moreover, when glucose tolerance test was performed in Type I Sprague-Dawley rat induced by streptozotocin using the soybean ferments [0.5 g soybean ferment/kg body weight (CHP-0.5 group)] and 1.0 g soybean ferment/kg body weight (CHP-1.0 group), there were significant differences in glucose levels between diabetes-control group (265.3 mg/dL) and soybean ferment-treated groups (CHP-0.

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Synergistic antidiabetic activities of zinc, cyclo (His-Pro), and arachidonic acid

Cited by 41 publications

References 49 publications

Slow Acting Protein Extract from Fruit Pulp of Momordica charantia with Insulin Secretagogue and Insulinomimetic Activities

Slow Acting Protein Extract from Fruit Pulp of Momordica charantia with Insulin Secretagogue and Insulinomimetic Activities

Anti-Hyperglycemic Activity of Zinc Plus Cyclo (His-Pro) in Genetically Diabetic Goto-Kakizaki and Aged Rats

Enhancement of Cyclo-His-Pro (CHP) Content from Soybean Fermented with Bacillus amyloliquefaciens CHP-12 and Its Anti-diabetic Effect

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