Synergistic antimicrobial profiling of violacein with commercial antibiotics against pathogenic micro-organisms

Abstract

Violacein works synergistically with most commercial antibiotics and could be used as drug in combination with other antimicrobial agents.

Violacein antimicrobial activity onStaphylococcus epidermidisand synergistic effect on commercially available antibiotics

“…Studies show that VIO interacts synergistically with several commercially available antibiotics on Salmonella typhi , Vibrio cholera , P. aeruginosa , K. pneumonia and S. aureus , and with azole antifungals (ketoconazole, fluconazole, clotrimazole and itraconazole) on the dermatophyte fungus Trichophyton rubrum (Subramaniam et al . ; Anju et al . ).…”

In vitro Antibacterial Activity of <i>Manilkara hexandra</i> (Sapotaceae) Seed Extracts and Violacein against Multidrug Resistant <i>Streptococcus mutans

“…MIC of Violacein against S. aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Vibrio cholerae, and Salmonella typhi was reported to be in the range of 5.7-20 µg/mL. Violacein has also been shown to work synergistically with most commercial antibiotics, and hence may be used as drug in combination with other antimicrobial agents [38][39][40]. Violacein was also reported to have an inhibitory effect on gram-negative Meningococcus, and the mold Blastomyces dermatitidis [41].…”

Advances in Chromobacterium violaceum and properties of violacein-Its main secondary metabolite: A review

“…Combination of violacein with gentamicin and cefadroxil decreased the MIC to 1.0 μg/mL against S. aureus. Furthermore, this work revealed significant synergism for violacein combined with azithromycin and kanamycin against S. enterica Typhi (Subramaniam et al, 2014). Rajalakshmi et al (2011) published an interesting study showing the isolation of a C. violaceum strain from spoiled vegetables.…”

“…In a recent work by Subramaniam et al (2014) the combined activity of violacein extracted from C. violaceum Bergonzini (Neisseriaceae) and commercial antibiotics was published. The authors established MIC values of 5.7 μg/mL for S. aureus and Salmonella enterica Typhi, 15.6 μg/mL for Klebsiella pneumoniae, 18.5 μg/mL for Pseudomonas aeruginosa and 20.0 μg/mL for Vibrio cholerae.…”