Synergistic Antioxidant and Anti‐Inflammatory Effects between Modified Citrus Pectin and Honokiol

Ramachandran, C; Eliaz, Isaac; Melnick, Steven J.; Eliaz, Isaac

doi:10.1155/2017/8379843

Cited by 37 publications

(26 citation statements)

References 53 publications

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“…In addition, the combination of two or more natural products with complementary beneficial activities should provide promising new alternatives to be explored. For example, a study revealed that both honokiol and modified citrus pectin induced dose-dependent antioxidant activity in a synergistic manner, inhibiting NF-kB and TNF-α (Ramachandran et al, 2017 ). The reviewed work suggests that combination of natural products in appropriated formulations represent a viable strategy for the treatment of skin conditions associated with inflammation and oxidative stress.…”

Section: Conclusion and Future Challengesmentioning

confidence: 99%

Natural Antioxidants: Multiple Mechanisms to Protect Skin From Solar Radiation

et al. 2018

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Human skin exposed to solar ultraviolet radiation (UVR) results in a dramatic increase in the production of reactive oxygen species (ROS). The sudden increase in ROS shifts the natural balance toward a pro-oxidative state, resulting in oxidative stress. The detrimental effects of oxidative stress occur through multiple mechanisms that involve alterations to proteins and lipids, induction of inflammation, immunosuppression, DNA damage, and activation of signaling pathways that affect gene transcription, cell cycle, proliferation, and apoptosis. All of these alterations promote carcinogenesis and therefore, regulation of ROS levels is critical to the maintenance of normal skin homeostasis. Several botanical products have been found to exhibit potent antioxidant capacity and the ability to counteract UV-induced insults to the skin. These natural products exert their beneficial effects through multiple pathways, including some known to be negatively affected by solar UVR. Aging of the skin is also accelerated by UVR exposure, in particular UVA rays that penetrate deep into the epidermis and the dermis where it causes the degradation of collagen and elastin fibers via oxidative stress and activation of matrix metalloproteinases (MMPs). Because natural compounds are capable of attenuating some of the UV-induced aging effects in the skin, increased attention has been generated in the area of cosmetic sciences. The focus of this review is to cover the most prominent phytoproducts with potential to mitigate the deleterious effects of solar UVR and suitability for use in topical application.

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Section: Conclusion and Future Challengesmentioning

confidence: 99%

Natural Antioxidants: Multiple Mechanisms to Protect Skin From Solar Radiation

et al. 2018

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“…Table 2 summarizes the key phytochemicals that are reported to have a TNF-α inhibitory effect in diverse experimental models, indicating their potential as plausible anti-TNF-α therapy. In vitro [99,100] Panax ginseng Ginsenoside Rg1 TNF-α mediated inflammatory cascades can be lowered by four main mechanisms, such as (1) by inhibiting the binding of TNF-α to TNFR1, (2) by lowering the activation of TACE that lowered the TNF-α production, (3) lowering the activation signaling that are responsible for TNF-α production, and (4) TNF-α degradation. Above mentioned medicinal plants, and their active chemicals target in one/more of these pathways and hence lowers the TNF-α and its related inflammatory pathways.…”

Section: Phytochemicals Inhibiting Tnf-α For Lowering the Neuroinflammentioning

confidence: 99%

Phytochemicals against TNFα-Mediated Neuroinflammatory Diseases

Subedi

Lee

Madiha

et al. 2020

IJMS

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Tumor necrosis factor-alpha (TNF-α) is a well-known pro-inflammatory cytokine responsible for the modulation of the immune system. TNF-α plays a critical role in almost every type of inflammatory disorder, including central nervous system (CNS) diseases. Although TNF-α is a well-studied component of inflammatory responses, its functioning in diverse cell types is still unclear. TNF-α functions through its two main receptors: tumor necrosis factor receptor 1 and 2 (TNFR1, TNFR2), also known as p55 and p75, respectively. Normally, the functions of soluble TNF-α-induced TNFR1 activation are reported to be pro-inflammatory and apoptotic. While TNF-α mediated TNFR2 activation has a dual role. Several synthetic drugs used as inhibitors of TNF-α for diverse inflammatory diseases possess serious adverse effects, which make patients and researchers turn their focus toward natural medicines, phytochemicals in particular. Phytochemicals targeting TNF-α can significantly improve disease conditions involving TNF-α with fewer side effects. Here, we reviewed known TNF-α inhibitors, as well as lately studied phytochemicals, with a role in inhibiting TNF-α itself, and TNF-α-mediated signaling in inflammatory diseases focusing mainly on CNS disorders.

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“…Citrus MP inhibits in vitro and in vivo angiogenesis in different types of cancer by blocking the association of galectin-3 to its receptors (Zhang, Xu, & Zhang, 2015). Other beneficial health properties might include the reduction of atherosclerotic lesions (Lu et al, 2017), anti-inflammatory and antioxidant properties (Popov & Ovodov, 2013;Ramachandran, Wilk, Melnick, & Eliaz, 2017) or immunostimulatory properties (Vogt et al, 2016). However, most of these studies were performed using cell cultures or in mice and extrapolation of the results to human or clinical investigations should be considered with caution.…”

Section: Introductionmentioning

confidence: 99%

In vitro fermentation properties of pectins and enzymatic-modified pectins obtained from different renewable bioresources

Ferreira-Lazarte

Kachrimanidou

Villamiel

et al. 2018

Carbohydrate Polymers

112

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The suitability of artichoke and sunflower by-products as renewable sources of pectic compounds with prebiotic potential was evaluated by studying their ability to modulate the human faecal microbiota in vitro. Bacterial populations and short-chain fatty acid (SCFA) production were measured. Reduction of the molecular weight of artichoke pectin resulted in greater stimulation of the growth of Bifidobacterium, Lactobacillus and Bacteroides/Prevotella, whilst this effect was observed only in Bacteroides/Prevotella for sunflower samples. In contrast, the degree of methoxylation did not have any impact on fermentability properties or SCFA production, regardless of the origin of pectic compounds. Although further in vivo studies should be conducted, either pectin or enzymatically-modified pectin from sunflower and artichoke by-products might be considered as prebiotic candidates for human consumption showing similar ability to promote the in vitro growth of beneficial gut bacteria as compared to well-recognized prebiotics such as inulin or fructo-oligosaccharides.

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Synergistic Antioxidant and Anti‐Inflammatory Effects between Modified Citrus Pectin and Honokiol

Cited by 37 publications

References 53 publications

Natural Antioxidants: Multiple Mechanisms to Protect Skin From Solar Radiation

Natural Antioxidants: Multiple Mechanisms to Protect Skin From Solar Radiation

Phytochemicals against TNFα-Mediated Neuroinflammatory Diseases

In vitro fermentation properties of pectins and enzymatic-modified pectins obtained from different renewable bioresources

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