2015
DOI: 10.1016/j.canlet.2014.11.026
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Synergistic antitumor activity of withaferin A combined with oxaliplatin triggers reactive oxygen species-mediated inactivation of the PI3K/AKT pathway in human pancreatic cancer cells

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Cited by 101 publications
(53 citation statements)
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“…These findings manifest that WFA can be able to upregulate the activity of both the initiator and effector caspases 9 and 3 and thereby confirming the pro-apoptotic activity of WFA. Few studies also indicated that WFA can act as pro-oxidant and thus trigger oxidative stress to induce apoptosis (Vyas and Singh, 2014;Li et al, 2015).…”
Section: Resultsmentioning
confidence: 99%
“…These findings manifest that WFA can be able to upregulate the activity of both the initiator and effector caspases 9 and 3 and thereby confirming the pro-apoptotic activity of WFA. Few studies also indicated that WFA can act as pro-oxidant and thus trigger oxidative stress to induce apoptosis (Vyas and Singh, 2014;Li et al, 2015).…”
Section: Resultsmentioning
confidence: 99%
“…In another study, glioma cell migration and invasion have also been correlated to Akt activation [47]. Ashwagandha has been reported to inhibit phosphorylation of Akt in several cancer cell lines such as pancreatic cancer, leukemia, and neuroblastomas [48,49]. The inhibition of Akt phosphorylation after treatment with ASH-WEX in C6 cells in vitro and in tumor allografts in vivo could possibly indicate the pro-apoptotic and anti-migratory/invasive role of ASH-WEX partially via disrupting the Akt/PI3K signaling pathway.…”
Section: Discussionmentioning
confidence: 96%
“…However, in more than 60 % of GBMs and other HGGs, PTEN is inactivated by genetic alterations, allowing PI3K to act uninhibited [59]. Phosphorylated PTEN levels were also reduced in combination therapy with no significant change in total PTEN levels [58].…”
Section: Mapk/erk Pathwaymentioning
confidence: 98%