Synergistic antitumor effect of Andrographolide and cisplatin through ROS-mediated ER stress and STAT3 inhibition in colon cancer

Hong, Hui; Cao, Weilan; Wang, Quanpeng; Liu, Changbao; Huang, Chun-Chieh

doi:10.1007/s12032-022-01691-2

Cited by 12 publications

(5 citation statements)

References 46 publications

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“…Andro subsequently increased intracellular ROS in osteosarcoma cell lines, HOS, U2OS, SAOS‐2, and MG‐63 52 . Andro enhanced intracellular ROS generation in HCT116 colon cancer cells 53 . The administration of 4‐MTBITC and PTX resulted in enhanced intracellular ROS and decrease in MMP within T‐47D breast cancer cells 54 .…”

Section: Discussionmentioning

confidence: 99%

“…52 Andro enhanced intracellular ROS generation in HCT116 colon cancer cells. 53 The administration of 4-MTBITC and PTX resulted in enhanced intracellular ROS and decrease in MMP within T-47D breast cancer cells. 54 Additionally, this study also revealed Andro-mediated decrease in GSH activity within PTX and DOX-treated resistant KBCh R 8-5 cancer cells.…”

Section: Effect Of Andro On Expression Of Abcb1 and Akt In Kbch R 8-5...mentioning

confidence: 98%

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Andrographolide reverts multidrug resistance in KBCh^R 8‐5 cells through AKT signaling pathway

Lakra,

Bharathiraja,

Dhanalakshmi

et al. 2024

Cell Biochemistry & Function

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Multidrug resistance (MDR) is a major obstacle in cancer chemotherapy. P‐glycoprotein (P‐gp) one of the ATP‐binding cassette (ABC) transporters plays an important role in MDR. In this study, we examined the sensitizing property of andrographolide (Andro) to reverse MDR in the drug‐resistant KBChR 8‐5 cells. Andro exhibited increased cytotoxicity in a concentration‐dependent manner in the P‐gp overexpressing KBChR 8‐5 cells. Furthermore, Andro showed synergistic interactions with PTX and DOX in this drug‐resistant cells. Andro co‐administration enhanced PTX‐ and DOX‐induced cytotoxicity and reduced cell proliferation in the MDR cancer cells. Moreover, reactive oxygen species (ROS) were elevated with a decrease in the mitochondrial membrane potential (MMP) during Andro and chemotherapeutic drugs combination treatment in the drug‐resistant cells. Furthermore, Andro and PTX‐induced cell cycle arrest was observed in the drug‐resistant cell. We also noticed that the expression of ABCB1 and AKT were downregulated during Andro (4 µM) treatment. Furthermore, Andro treatment enhanced the expression of caspase 3 and caspase 9 in the combinational groups that support the enhanced apoptotic cell death in drug‐resistant cancer cells. Therefore, the results reveal that Andro plays a role in the reversal of P‐gp‐mediated MDR in KBChR 8‐5 cells which might be due to regulating ABCB1/AKT signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Section: Effect Of Andro On Expression Of Abcb1 and Akt In Kbch R 8-5...mentioning

confidence: 98%

Andrographolide reverts multidrug resistance in KBCh^R 8‐5 cells through AKT signaling pathway

Lakra,

Bharathiraja,

Dhanalakshmi

et al. 2024

Cell Biochemistry & Function

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“…Andrographolide Scutellarin enhanced the efficacy of 5-fluorouracil in treating CRC while reversing resistance to 5-fluorouracil in patients with colon cancer [ 149 , 150 , 151 ]. Andrographolide synergistically enhances the antitumor effect of oxaliplatin on CRC cells [ 152 ], while also enhancing radiosensitivity [ 153 ]. Resveratrol enhances the cytotoxic effect of 5-fluorouracil on colorectal tumors [ 154 ].…”

Section: Tcms With Anti-crc Effects Through Tlr4 Signaling Pathwaymentioning

confidence: 99%

The Role of Natural Products from Herbal Medicine in TLR4 Signaling for Colorectal Cancer Treatment

Luo,

Zhang,

et al. 2024

Molecules

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The toll-like receptor 4 (TLR4) signaling pathway constitutes an intricate network of protein interactions primarily involved in inflammation and cancer. This pathway triggers intracellular signaling cascades, modulating transcription factors that regulate gene expression related to immunity and malignancy. Previous studies showed that colon cancer patients with low TLR4 expression exhibit extended survival times and the TLR4 signaling pathway holds a significant role in CRC pathogenesis. In recent years, traditional Chinese medicines (TCMs) have garnered substantial attention as an alternative therapeutic modality for CRC, primarily due to their multifaceted composition and ability to target multiple pathways. Emerging evidence indicates that specific TCM products, such as andrographolide, rosmarinic acid, baicalin, etc., have the potential to impede CRC development through the TLR4 signaling pathway. Here, we review the role and biochemical processes of the TLR4 signaling pathway in CRC, and natural products from TCMs affecting the TLR4 pathway. This review sheds light on potential treatment strategies utilizing natural TLR4 inhibitors for CRC, which contributes to the advancement of research and accelerates their clinical integration into CRC treatment.

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“…In the past few years, several interesting articles have been published concerning the inducing effect on both apoptosis and autophagy of drugs, mostly of natural origin, through regulatory pathways mediated by oxidative stress [ 61 , 62 , 63 , 64 , 65 ]. In this regard, a study investigated how β-elemene, extracted from the genus Curcuma, affected cells in vitro and in vivo.…”

Section: Oxidative Stress and Modulation Of Autophagy And Apoptosismentioning

confidence: 99%

Different Roles of Apoptosis and Autophagy in the Development of Human Colorectal Cancer

Orlandi

Roncucci

Carnevale

et al. 2023

IJMS

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Colorectal cancer (CRC) remains a major life-threatening malignancy, despite numerous therapeutic and screening attempts. Apoptosis and autophagy are two processes that share common signaling pathways, are linked by functional relationships and have similar protein components. During the development of cancer, the two processes can trigger simultaneously in the same cell, causing, in some cases, an inhibition of autophagy by apoptosis or apoptosis by autophagy. Malignant cells that have accumulated genetic alterations can take advantage of any alterations in the apoptotic process and as a result, progress easily in the cancerous transformation. Autophagy often plays a suppressive role during the initial stages of carcinogenicity, while in the later stages of cancer development it can play a promoting role. It is extremely important to determine the regulation of this duality of autophagy in the development of CRC and to identify the molecules involved, as well as the signals and the mechanisms behind it. All the reported experimental results indicate that, while the antagonistic effects of autophagy and apoptosis occur in an adverse environment characterized by deprivation of oxygen and nutrients, leading to the formation and development of CRC, the effects of promotion and collaboration usually involve an auxiliary role of autophagy compared to apoptosis. In this review, we elucidate the different roles of autophagy and apoptosis in human CRC development.

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Synergistic antitumor effect of Andrographolide and cisplatin through ROS-mediated ER stress and STAT3 inhibition in colon cancer

Cited by 12 publications

References 46 publications

Andrographolide reverts multidrug resistance in KBCh^R 8‐5 cells through AKT signaling pathway

Andrographolide reverts multidrug resistance in KBCh^R 8‐5 cells through AKT signaling pathway

The Role of Natural Products from Herbal Medicine in TLR4 Signaling for Colorectal Cancer Treatment

Different Roles of Apoptosis and Autophagy in the Development of Human Colorectal Cancer

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Synergistic antitumor effect of Andrographolide and cisplatin through ROS-mediated ER stress and STAT3 inhibition in colon cancer

Cited by 12 publications

References 46 publications

Andrographolide reverts multidrug resistance in KBChR 8‐5 cells through AKT signaling pathway

Andrographolide reverts multidrug resistance in KBChR 8‐5 cells through AKT signaling pathway

The Role of Natural Products from Herbal Medicine in TLR4 Signaling for Colorectal Cancer Treatment

Different Roles of Apoptosis and Autophagy in the Development of Human Colorectal Cancer

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Product

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Andrographolide reverts multidrug resistance in KBCh^R 8‐5 cells through AKT signaling pathway

Andrographolide reverts multidrug resistance in KBCh^R 8‐5 cells through AKT signaling pathway