2024
DOI: 10.1101/2024.02.01.578341
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Synergistic Antitumor Effect of Naproxen and Sorafenib in Hepatocellular Carcinoma

Etkin Akar,
Seyma Unsal Beyge,
Deniz Cansen Kahraman

Abstract: Hepatocellular carcinoma (HCC) is one of the most prevalent and deadliest cancer types in the world. Due to the inevitable development of resistance to classical chemotherapy and current targeted therapies, combination therapy became an important strategy. Recently drug repurposing studies have emphasized the potential of non-steroidal anti-inflammatory drugs (NSAIDs) in exhibiting anti-tumor activities in different cancer types, including HCC. In this study, we explored the synergistic bioactivity of naproxen… Show more

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