Synergistic bactericidal effects of acrinol and tetracycline against Pseudomonas aeruginosa

Tomimasu

et al. 2005

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

ANDP-7, a Novel Acrinol Degradation Product by Light

Tomimasu

et al. 2005

“…Synergistic effects of acrinol with other antibiotics and the influence of light on the antimicrobial activity of acrinol solution have been reported. [1][2][3][4] Degradation of acrinol by light, however, has not been clarified, although color change of the acrinol liniment or ointment occurs by light irradiation.…”

Section: Introductionmentioning

confidence: 99%

Acrinol Degradation Products (ANDP)-8, A Novel Acrinol Degradation Product by Light

Nakamoto

et al. 2004

To clarify the degradation pathway of acrinol by light, isolation and identification of acrinol degradation products (ANDP) were attempted. A novel acrinol degradation product, ANDP-8, one of the ANDPs, was isolated by extraction with methanol from cloths dampened with acrinol solution, and purified by column chromatography on Diaion HP-10 and Sephadex LH-20. The structural elucidation of ANDP-8 was examined by infrared, 1 H-NMR, 13 C-NMR and electron impact ionization (EI)-mass spectra studies. From the spectroscopic data, the structure of ANDP-8 was determined to be 2-ethoxyl-6, 9-acridinediamine-5, 8-dione, that was found to be a novel degradation product of acrinol by light. Antimicrobial activities of ANDP-8 against Gram-positive bacteria were 10 to 100-fold higher than those of acrinol. ANDP-8 was also active against yeast and fungi. Nevertheless, acrinol did not show growth inhibition even at a concentration of 100 g/ml.

show abstract

“…Synergistic bacterial effects of acrinol with other antibiotics and the influence of light on the antimicrobial activity of acrinol and of acrinol with other antibiotics have been reported. [1][2][3][4] The degradation product of acrinol by light, however, has not been clarified, although color change of the acrinol liniment or ointment occurs by light irradiation. The degradation products of acrinol by light were produced after long time irradiation (more than three month).…”

Section: Introductionmentioning

confidence: 99%

ANDP-2, A Novel Acrinol Degradation Product by Light

Yoshioka

et al. 2007