Synergistic Benefits on Combining Injectable Platelet-Rich Fibrin and Bone Graft Porous Particulate Materials

Oliveira, Miguel Noronha; Varela, Hugo Almeida; Caramês, João; Silva, Filipe; Henriques, Bruno; Teughels, Wim; Quirynen, Marc; Souza, Júlio C. M.

doi:10.1007/s44174-022-00004-5

Cited by 2 publications

(1 citation statement)

References 86 publications

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“…The formation of blood vessels takes place in the macro-scale spaces among particulate biomaterials with distance between 50 and 400 µm. A combination of granules and hydrogels has been studied to improve clinical handling of particulate bone graft materials and to control the distribution of granules in a bone defect [55][56][57]. Hydrogels (i.e., such as collagen-or fibrinbased materials) have been used to preserve a three-dimensional homogeneous distribution of graft material in a bone defect, maintaining adequate inter-granule spacing [55,56].…”

Section: In Vivo Evidence Of Bone Healingmentioning

confidence: 99%

Tooth-Derived Matrix Granules for Enhanced Bone Healing: Chemical Composition, Morphological Aspects, and Clinical Outcomes

et al. 2022

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Bone grafting has increasingly been used in surgical procedures for enhanced bone augmentation. Tooth-derived graft material has received considerable attention due to its chemical composition and autogenous source that can improve bone tissue healing. The main aim of this study was to provide a short and comprehensive review on the chemical composition, morphological aspects, and clinical outcomes of bone grafting using tooth-derived matrix granules. Dentin tissue has a chemical composition similar to that on bone tissues regarding the presence of hydroxyapatite, type I collagen, and different growth factors. Dentin-matrix granules are often processed at well-controlled size ranging from approximately 300 up to 1300 µm, while maintaining porosity and organic content. In addition, a dense collagen fiber network is still present after the milling and chemical treatment of dentin granules. Thus, dentin-matrix granules can improve the bone healing process considering their chemical composition, porous structure, and adequate size. However, further in vivo and in vitro studies should be performed taking into consideration different demineralization procedures, remnant organic content, porosity, and granule size.

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Section: In Vivo Evidence Of Bone Healingmentioning

confidence: 99%

Tooth-Derived Matrix Granules for Enhanced Bone Healing: Chemical Composition, Morphological Aspects, and Clinical Outcomes

et al. 2022

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Porous Zirconia Blocks Embedded with Platelet Rich Fibrin for Enhanced Bone Healing: Mechanical and Morphological Assessment

Sampaio

Oliveira

Carvalho

et al. 2023

Biomedical Materials & Devices

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Extensive bone defects can not be repaired with traditional porous blocks composed of graft ceramics concerning the low strength of the materials. In this way, zirconia porous blocks become alternative bone graft material for repairing of extensive bone sites considering their physical properties. The main aim of this study was to evaluate the compressive strength and morphological aspects of porous zirconia blocks embedded with platelet rich fibrin for enhanced bone healing. Porous blocks composed of yttria-stabilized zirconia polycrystals (Y-TZP) were manufactured by the replica method using a polyurethane sponge. Specimens were submitted to a heat treatment at 1 °C/min up to 1500 °C for 120 min. Half of specimens were embedded with an injectable platelet rich fibrin (i-PRF). On i-PRF, harvested blood was immediately centrifuged by using a high-quality table centrifuge at 2700 rpm (408 g) and at room temperature for 3 min. Random specimens were prepared for morphological analyses by optical and scanning electron microscopy. Groups of specimens were mechanically assessed by compressive strength and nano-indentation tests. Porous structures composed of (Y-TZP) revealed high strength values even though interconnected pores had large dimensions. The size of pores was proper for cell migration, bone ingrowth, and angiogenesis. The incorporation of platelet rich fibrin promoted an increase in compressive strength of the porous YTZP structure. However, a decrease in strength of the porous structures was noted with the increase of number and size of pores. Fragile porous zirconia blocks can reveal an adequate strength for surgical handling and tissue healing at extensive bone repair. Also, the incorporation of further bioactive absorbable materials such as platelet rich fibrin increases the strength of the porous structures. The combination of zirconia porous blocks and platelet rich fibrin can enhance the bone healing leading to low risks of clinical issues. Graphical Abstract

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Synergistic Benefits on Combining Injectable Platelet-Rich Fibrin and Bone Graft Porous Particulate Materials

Cited by 2 publications

References 86 publications

Tooth-Derived Matrix Granules for Enhanced Bone Healing: Chemical Composition, Morphological Aspects, and Clinical Outcomes

Tooth-Derived Matrix Granules for Enhanced Bone Healing: Chemical Composition, Morphological Aspects, and Clinical Outcomes

Porous Zirconia Blocks Embedded with Platelet Rich Fibrin for Enhanced Bone Healing: Mechanical and Morphological Assessment

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