Synergistic chemo-photodynamic therapy based on hollow mesoporous organosilica nanoparticles for reducing psoriasis-like inflammation

Fan, Zhijia; Zhao, Gang; Gan, Yixiao; Wei, Li; Xia, Rong; Lu, Min; Wang, Zhicheng

doi:10.1016/j.cej.2024.151613

Chemical Engineering Journal

2024

DOI: 10.1016/j.cej.2024.151613

|View full text |Cite

Synergistic chemo-photodynamic therapy based on hollow mesoporous organosilica nanoparticles for reducing psoriasis-like inflammation

Zhijia Fan,

Gang Zhao,

Yixiao Gan

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

2025

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Biodegradable Acid‐Responsive Nanocarrier for Enhanced Antibiotic Therapy Against Drug‐Resistant Helicobacter Pylori via Urease Inhibition

Fan,

Wong,

et al. 2024

Adv Funct Materials

View full text Add to dashboard Cite

Metal ion‐based inhibition of urease activity is a promising strategy for treating Helicobacter pylori (H. pylori) infections. However, the challenges of safe delivery and reducing cytotoxicity persist. In this study, an innovative nanocarrier capable of acid‐responsive release of Ag+ and antibiotics is developed, with complete degradation after treatment. Mesoporous organosilica nanoparticle (MON) is encapsulated with hyaluronic acid (HA) to prevent drug leakage and further coated with bacterial outer membrane vesicle (OMV) from Escherichia coli Nissle 1917, creating a nanocarrier with cell‐protective capabilities. Ag+ and antibiotic clarithromycin (CLR) are incorporated into the nanocarrier to form CLR‐Ag+@MON@HA@OMV (CAMO), designed for the targeted treatment of gastric H. pylori infection. The HA encapsulation ensures acid‐responsive release of CLR and Ag+ in the stomach, preventing premature release at non‐inflammatory sites. There is a potential for Ag⁺ in CAMO to replace Ni2⁺ at the active site of urease, enhancing the bactericidal effect of CLR through urease inhibition. Furthermore, the OMV provides additional cytoprotection, mitigating cell damage and inflammation response induced by the H. pylori infection. This study introduces a safe and effective nanocarrier that eradicates H. pylori and alleviates gastric inflammation.

show abstract

Biodegradable Acid‐Responsive Nanocarrier for Enhanced Antibiotic Therapy Against Drug‐Resistant Helicobacter Pylori via Urease Inhibition

Fan,

Wong,

et al. 2024

Adv Funct Materials

View full text Add to dashboard Cite

show abstract

Intradermal implantation of methotrexate-loaded puerarin-gelatin hydrogel via bubble-generating microneedles for psoriasis treatment

Zhao,

Liu,

Shi

et al. 2025

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

Recent Advances in Hollow Nanostructures: Synthesis Methods, Structural Characteristics, and Applications in Food and Biomedicine

Li,

Liu,

McClements

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Synergistic chemo-photodynamic therapy based on hollow mesoporous organosilica nanoparticles for reducing psoriasis-like inflammation

Cited by 3 publications

References 54 publications

Biodegradable Acid‐Responsive Nanocarrier for Enhanced Antibiotic Therapy Against Drug‐Resistant Helicobacter Pylori via Urease Inhibition

Biodegradable Acid‐Responsive Nanocarrier for Enhanced Antibiotic Therapy Against Drug‐Resistant Helicobacter Pylori via Urease Inhibition

Intradermal implantation of methotrexate-loaded puerarin-gelatin hydrogel via bubble-generating microneedles for psoriasis treatment

Recent Advances in Hollow Nanostructures: Synthesis Methods, Structural Characteristics, and Applications in Food and Biomedicine

Contact Info

Product

Resources

About