Synergistic chemoprotective mechanisms of dietary phytoestrogens in a select combination against prostate cancer

Kumar, Rajeev; Verma, Vikas; Jain, Ashish; Jain, Rajeev; Maikhuri, Jagdamba P.; Gupta, Gopal

doi:10.1016/j.jnutbio.2010.06.003

Cited by 61 publications

(54 citation statements)

References 54 publications

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“…Results predict that taking apigenin-enriched foods or food supplements may have bortezomib-like effects against prostate cancer. The apigenin effect may further be potentiated by the presence of other similar natural products due to synergistic action [37]. On the other hand, apigenin's non-toxic nature and unique mechanisms of action may add considerably to its safety and help it to escape resistance by prostate cancer cells as encountered in the case of bortezomib.…”

Section: Discussionmentioning

confidence: 99%

Apigenin manipulates the ubiquitin–proteasome system to rescue estrogen receptor-β from degradation and induce apoptosis in prostate cancer cells

et al. 2014

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Apigenin selectively inhibits proteasomal degradation of tumor suppressor ER-β by specifically inhibiting chymotrypsin-like activity of proteasome, preventing its assembly via PSMA5 and inhibiting USP14 enzyme activity in prostate cancer cells, resulting in cancer cell apoptosis. Unlike bortezomib, apigenin's actions are subtle, precise, mechanistically distinct and capable of abstaining drug resistance.

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Section: Discussionmentioning

confidence: 99%

Apigenin manipulates the ubiquitin–proteasome system to rescue estrogen receptor-β from degradation and induce apoptosis in prostate cancer cells

et al. 2014

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“…Many studies have been carried out particularly on BCL-2 expression. According to one study, a combination of genistein, quercetin and biochanin-A was significantly more effective than individual compounds or their double combinations in decreasing BCL-2 mRNA expression as well as protein levels in prostate cancer (Kumar et al, 2010) …”

Section: Dietmentioning

confidence: 99%

A single nucleotide polymorphism in BCL-2 gene determines the risk of urinary bladder cancer

Kaur¹

2014

IOSRJPBS

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“…An in vitro study conducted by Kumar et al [72] described a synergistic effect from a combination of three phytoestrogens that included genistein, biochanin, and quercetin. This combination inhibited the growth of androgen-responsive prostate cancer cells (LNCaP) as well as androgen-independent metastatic prostate cancer cells (DU-145) and PC-3 prostate cancer cells by both estrogen dependent and independent pathways and by stimulation of caspase-3 activity.…”

Section: Human Trials Of Phytoestrogens and Prostate Health And Diseasementioning

confidence: 99%

Phytoestrogens and their Potential Role in Prostate Cancer Prevention and Treatment

Kolukula¹

2011

J Cancer Sci Ther

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Phytoestrogens are hormonally active compounds present in plant foods that are being studied extensively for their potential roles in hormonally-sensitive neoplasms such as prostate cancer. We postulate that the evidence for a protective role of phytoestrogens is not conclusive enough for a general recommendation for their use as dietary supplements, but phytoestrogens can be considered for therapeutic use in prostate cancer patients under certain circumstances. A literature review was performed to study the evidence regarding the chemopreventive role of phytoestrogens in healthy men, the protective role in early prostate cancer, and a possible therapeutic role in advanced prostate cancer patients. Dietary supplementation with phytoestrogens for chemoprevention of prostate cancer is still a debatable subject. Numerous pre-clinical in vitro studies have been promising, and novel molecular mechanisms of action for phytoestrogens continue to be identified. However, human clinical trials including studies done on prostate biomarkers and on the effects of phytoestrogens on steroid hormones are complicated by the possibility of local paracrine effects in prostatic tissue by phytoestrogens that are steroid-like in structure. Their interaction with multiple enzymes represents a paradigm for the complexity of phytoestrogen effects and a window into a potential reason that study results are inconsistent or difficult to explain. A final outcome of the phytoestrogen effect in the intact human may be difficult to discern because these agents can inhibit or induce enzymes, destroy cancer cells, yet will have intrinsic estrogenic effects themselves. Larger multi-center, multi-national, randomized controlled trials are needed before definitive recommendations can be made on the usefulness of phytoestrogens for chemoprevention and therapy for prostate cancer. However, combinations of phytoestrogens with radiation therapy and other antioxidants in advanced or metastatic prostate cancer can be considered because there are limited effective therapy options for this group of patients.

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Synergistic chemoprotective mechanisms of dietary phytoestrogens in a select combination against prostate cancer

Cited by 61 publications

References 54 publications

Apigenin manipulates the ubiquitin–proteasome system to rescue estrogen receptor-β from degradation and induce apoptosis in prostate cancer cells

Apigenin manipulates the ubiquitin–proteasome system to rescue estrogen receptor-β from degradation and induce apoptosis in prostate cancer cells

A single nucleotide polymorphism in BCL-2 gene determines the risk of urinary bladder cancer

Phytoestrogens and their Potential Role in Prostate Cancer Prevention and Treatment

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