Synergistic Cytotoxicity Of Shikonin‐Silver Nanoparticles As An Opportunity For Lung Cancer

Fayez, Hend; El-Motaleb, Mohamed Abd; Selim, Adli A.

doi:10.1002/jlcr.3818

Cited by 35 publications

(15 citation statements)

References 28 publications

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“…However, it has already been shown for shikonin that there are ways to overcome this problem. Fayez et al [ 53 ] reported recently that a combination of shikonin and silver nanoparticles synergistically inhibited the growth of lung cancer cells. Wang et al [ 54 ] have shown that shikonin and JQ1, a bromodomain and extra-terminal motif (BET) inhibitor, encapsulated in lactoferrin nanoparticles changed the tumor immune microenvironment, activated immunogenic cell death, repolarized protumor phenotype, tumor-associated macrophages, and repressed glucose metabolism.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Pharmacological In Vitro Investigations of Novel Shikonin Derivatives with a Special Focus on Cyclopropane Bearing Derivatives

Kretschmer

Hüfner

Durchschein

et al. 2021

IJMS

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Melanoma is the deadliest form of skin cancer and accounts for about three quarters of all skin cancer deaths. Especially at an advanced stage, its treatment is challenging, and survival rates are very low. In previous studies, we showed that the constituents of the roots of Onosma paniculata as well as a synthetic derivative of the most active constituent showed promising results in metastatic melanoma cell lines. In the current study, we address the question whether we can generate further derivatives with optimized activity by synthesis. Therefore, we prepared 31, mainly novel shikonin derivatives and screened them in different melanoma cell lines (WM9, WM164, and MUG-Mel2 cells) using the XTT viability assay. We identified (R)-1-(1,4-dihydro-5,8-dihydroxy-1,4-dioxonaphthalen-2-yl)-4-methylpent-3-enyl 2-cyclopropyl-2-oxoacetate as a novel derivative with even higher activity. Furthermore, pharmacological investigations including the ApoToxGloTM Triplex assay, LDH assay, and cell cycle measurements revealed that this compound induced apoptosis and reduced cells in the G1 phase accompanied by an increase of cells in the G2/M phase. Moreover, it showed hardly any effects on the cell membrane integrity. However, it also exhibited cytotoxicity against non-tumorigenic cells. Nevertheless, in summary, we could show that shikonin derivatives might be promising drug leads in the treatment of melanoma.

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Section: Resultsmentioning

confidence: 99%

Synthesis and Pharmacological In Vitro Investigations of Novel Shikonin Derivatives with a Special Focus on Cyclopropane Bearing Derivatives

Kretschmer

Hüfner

Durchschein

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…With the advancement of science and technology, researchers from all over the world have been focusing on the synergistic detoxification effects of potent drug molecules in combination or association with other components such as drug-metal nanoparticles, drug-carbon dots, and drug-related derivatives. These types of synergistic detoxification methodologies have emerged rapidly in recent years, particularly in cancer and other deteriorative ailments' treatment Advancement in cancer treatment studies show the potential of shikonin-AgNPs (silver nanoparticles) nanoparticles against A549 cells (human lung carcinoma cell line) (Fayez et al, 2020). Shikonin used in the synthesis of AgNPs reduced the hazards related to toxic chemicals, and together they possess inhibitory and proliferation activity against A549 cells (Fayez et al, 2020).…”

Section: Antitumoral and Anti-cancer Effectsmentioning

confidence: 99%

“…These types of synergistic detoxification methodologies have emerged rapidly in recent years, particularly in cancer and other deteriorative ailments' treatment Advancement in cancer treatment studies show the potential of shikonin-AgNPs (silver nanoparticles) nanoparticles against A549 cells (human lung carcinoma cell line) (Fayez et al, 2020). Shikonin used in the synthesis of AgNPs reduced the hazards related to toxic chemicals, and together they possess inhibitory and proliferation activity against A549 cells (Fayez et al, 2020). The IC50 of shikonin-AgNPs determined by MTT assay after 24 h was 2.4 ± 0.11 μg/ml (Fayez et al, 2020).…”

Section: Antitumoral and Anti-cancer Effectsmentioning

confidence: 99%

Review of Shikonin and Derivatives: Isolation, Chemistry, Biosynthesis, Pharmacology and Toxicology

et al. 2022

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Shikonin and its derivatives, isolated from traditional medicinal plant species of the genus Lithospermum, Alkanna, Arnebia, Anchusa, Onosma, and Echium belonging to the Boraginaceae family, have numerous applications in foods, cosmetics, and textiles. Shikonin, a potent bioactive red pigment, has been used in traditional medicinal systems to cure various ailments and is well known for its diverse pharmacological potential such as anticancer, antithrombotic, neuroprotective, antidiabetic, antiviral, anti-inflammatory, anti-gonadotropic, antioxidants, antimicrobial and insecticidal. Herein, updated research on the natural sources, pharmacology, toxicity studies, and various patents filed worldwide related to shikonin and approaches to shikonin’s biogenic and chemical synthesis are reviewed. Furthermore, recent studies to establish reliable production systems to meet market demand, functional identification, and future clinical development of shikonin and its derivatives against various diseases are presented.

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“…Through radioiodination of 131 I to the synthesized shikonin-AgNPs, biodistribution studies by gamma counting showed their highest preferential retention time in the lung tissues at all-time points compared to other organs, indicating specific targeting in lungs. Moreover, shikonin-AgNPs also showed inhibitory effects for A549 cells in cell viability and proliferation [37]. AuNPs were used as delivery cargos to deliver boron atoms to cancer cells for boron neutron capture therapy (BNCT).…”

Section: Nanomaterials For Theranostic Nuclear Imaging Probesmentioning

confidence: 99%

Nanomaterial Probes for Nuclear Imaging

et al. 2022

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Nuclear imaging is a powerful non-invasive imaging technique that is rapidly developing in medical theranostics. Nuclear imaging requires radiolabeling isotopes for non-invasive imaging through the radioactive decay emission of the radionuclide. Nuclear imaging probes, commonly known as radiotracers, are radioisotope-labeled small molecules. Nanomaterials have shown potential as nuclear imaging probes for theranostic applications. By modifying the surface of nanomaterials, multifunctional radio-labeled nanomaterials can be obtained for in vivo biodistribution and targeting in initial animal imaging studies. Various surface modification strategies have been developed, and targeting moieties have been attached to the nanomaterials to render biocompatibility and enable specific targeting. Through integration of complementary imaging probes to a single nanoparticulate, multimodal molecular imaging can be performed as images with high sensitivity, resolution, and specificity. In this review, nanomaterial nuclear imaging probes including inorganic nanomaterials such as quantum dots (QDs), organic nanomaterials such as liposomes, and exosomes are summarized. These new developments in nanomaterials are expected to introduce a paradigm shift in nuclear imaging, thereby creating new opportunities for theranostic medical imaging tools.

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Synergistic Cytotoxicity Of Shikonin‐Silver Nanoparticles As An Opportunity For Lung Cancer

Cited by 35 publications

References 28 publications

Synthesis and Pharmacological In Vitro Investigations of Novel Shikonin Derivatives with a Special Focus on Cyclopropane Bearing Derivatives

Synthesis and Pharmacological In Vitro Investigations of Novel Shikonin Derivatives with a Special Focus on Cyclopropane Bearing Derivatives

Review of Shikonin and Derivatives: Isolation, Chemistry, Biosynthesis, Pharmacology and Toxicology

Nanomaterial Probes for Nuclear Imaging

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