Synergistic Effect of 3′,4′-Dihidroxifenilglicol and Hydroxytyrosol on Oxidative and Nitrosative Stress and Some Cardiovascular Biomarkers in an Experimental Model of Type 1 Diabetes Mellitus

Cruz, J. P. De La; Vallejo-Carmona, Leticia; Arrebola, María Monsalud; Martín-Aurioles, Esther; Rodríguez-Pérez, María Dolores; Ortega-Hombrados, Laura; Verdugo, Cristina; Fernández-Prior, África; Bermúdez-Oria, Alejandra; Correa, José Antonio González

doi:10.3390/antiox10121983

Cited by 10 publications

(14 citation statements)

References 32 publications

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“…The synergism between phenolic compounds could explain the superiority of whole OOs or phenolic extracts against pure phenolic compounds to inhibit platelet activation. A recent study of De La Cruz Cortés et al [57], clearly showed the synergistic effect of HT and DHPG in similar proportions found in EVOO to attenuate COL-induced platelet aggregation of diabetic rats and to spare prostacyclin synthesis by the aorta.…”

Section: Effect Of Phenolic Compounds/extracts Of Oo On Platelet Func...mentioning

confidence: 69%

“…The majority of the studies used rats as the preferred animal species while only one study used New Zealand rabbits. The pathological phenotypes induced by the researchers were either atherosclerosis (induced by an atherogenic diet) [55], diabetes (induced by streptozotocin) [56,57] while the rest of the intervention studies were conducted in healthy animals. The investigators administered [57] Rats (male Wistar) NDR: saline-treated non-diabetic rats either VOO [55,56,58], EVOOs with different concentrations of phenolics [59], HT [57,60], HTA [60], DHPG [57] and alkyl ether derivatives of HT [61].…”

Section: Effect Of Phenolic Compounds/extracts Of Oo On Platelet Func...mentioning

confidence: 99%

“…The pathological phenotypes induced by the researchers were either atherosclerosis (induced by an atherogenic diet) [55], diabetes (induced by streptozotocin) [56,57] while the rest of the intervention studies were conducted in healthy animals. The investigators administered [57] Rats (male Wistar) NDR: saline-treated non-diabetic rats either VOO [55,56,58], EVOOs with different concentrations of phenolics [59], HT [57,60], HTA [60], DHPG [57] and alkyl ether derivatives of HT [61]. The interventions lasted from 0 days (acute administration) to 3 months while the experimental oils/molecules were administered by oral gavage in the majority of the studies.…”

Section: Effect Of Phenolic Compounds/extracts Of Oo On Platelet Func...mentioning

confidence: 99%

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Olive Oil Phenolics and Platelets—From Molecular Mechanisms to Human Studies

Katsa¹,

Nomikos²

2022

Rev. Cardiovasc. Med.

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Chronically activated, dysfunctional platelets mediate the progression of the majority of non-communicable diseases in a pleiotropic fashion. Antiplatelet therapy remains an attractive therapeutic means which however hasn't reached the expected targets according to the promising preclinical studies. It is therefore obvious that the consumption of foods demonstrating antiplatelet activity may be a less drastic but on the other hand a more sustainable way of achieving daily antiplatelet therapy, either alone or in combination with antiplatelet drugs. Olive oil is probably the main cardioprotective component of the Mediterranean Diet according to the results of observational and dietary intervention studies. Among all phytochemicals of olive oil, its unique phenolics seems to be responsible for the majority of its cardioprotective properties. This review article aims to highlight the platelet modulating roles of olive oil polyphenols, trying to critically assess whether those properties could partially explain the cardioprotective role of olive oil. The cellular and animal studies clearly show that extra virging olive oil (EVOO) phenolics, mainly hydroxytyrosol, are able to inhibit the activation of platelets induced by several endogenous agonists and pathologies. However, the outcomes of the pre-clinical studies are difficult to be translated to humans mainly because the dosages and the chemical forms of the phenolics used to these studies are much higher and different to that found in human circulation. Despite the heterogeneity of the few human trials on the field so far, the results are promising showing that EVOO can exert antiplatelet actions in real, acute or long-term, trials and at least part of this antiplatelet action can be attributed to the phenolic content of EVOOs. Although we clearly need better, well-powered studies to give certain answers on this field the antiplatelet properties of olive oil phenolics is a promising, emerging mechanism which may explain some of the health properties of EVOO and the Mediterranean Diet.

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Section: Effect Of Phenolic Compounds/extracts Of Oo On Platelet Func...mentioning

confidence: 69%

Section: Effect Of Phenolic Compounds/extracts Of Oo On Platelet Func...mentioning

confidence: 99%

Section: Effect Of Phenolic Compounds/extracts Of Oo On Platelet Func...mentioning

confidence: 99%

See 1 more Smart Citation

Olive Oil Phenolics and Platelets—From Molecular Mechanisms to Human Studies

Katsa¹,

Nomikos²

2022

Rev. Cardiovasc. Med.

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“…Yet in vitro studies or animal models, even not concerning skeletal muscle, showed an interest in using a mixture of polyphenols. In fact, such a mixture of polyphenols is more active than each individual molecule alone as a synergy effect occurs between the molecules [ 205 , 206 ].…”

Section: Discussionmentioning

confidence: 99%

Grape Polyphenols in the Treatment of Human Skeletal Muscle Damage Due to Inflammation and Oxidative Stress during Obesity and Aging: Early Outcomes and Promises

et al. 2022

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Today, inactivity and high-calorie diets contribute to the development of obesity and premature aging. In addition, the population of elderly people is growing due to improvements in healthcare management. Obesity and aging are together key risk factors for non-communicable diseases associated with several co-morbidities and increased mortality, with a major impact on skeletal muscle defect and/or poor muscle mass quality. Skeletal muscles contribute to multiple body functions and play a vital role throughout the day, in all our activities. In our society, limiting skeletal muscle deterioration, frailty and dependence is not only a major public health challenge but also a major socio-economic issue. Specific diet supplementation with natural chemical compounds such as grape polyphenols had shown to play a relevant and direct role in regulating metabolic and molecular pathways involved in the prevention and treatment of obesity and aging and their related muscle comorbidities in cell culture and animal studies. However, clinical studies aiming to restore skeletal muscle mass and function with nutritional grape polyphenols supplementation are still very scarce. There is an urgent need for clinical studies to validate the very encouraging results observed in animal models.

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“… HT treatment decreased HDAC11 and HDAC11 mRNA expression. [ 34 ] Wistar rats (n = 60) Non-Diabetic rats Diabetic rats Diabetic + 5 mg/kg/day HT rats Diabetic + 0.5 mg/kg/day DHPG rats Diabetic + 0.5 mg/kg/day DHPG + HT rats Diabetic + 1 mg/kg/day DHPG + HT rats Every treatment were administrated in the drinking water once a day during 7 days before diabetes’ induction. Then, every treatment were administrated daily during 2 months.…”

Section: Hydroxytyrosol In Animal Studiesmentioning

confidence: 99%