Synergistic effect of cholecystokinin octapeptide and angiotensin II in reversal of morphine induced analgesia in rats

Han, N.L.; Luo, Fei; Bian, Zhu-Ping; Han, Ji-Sheng

doi:10.1016/s0304-3959(99)00294-8

Cited by 19 publications

(8 citation statements)

References 19 publications

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“…Synergism between ZOL and paclitaxel/cisplatin was evaluated by isobolographic analysis[24]. This method is referred to as a ‘gold standard’ because it is the only model of analysis proven valid for analyzing interactions between biologically active agents [24]–[28].…”

Section: Methodsmentioning

confidence: 99%

“…This method is referred to as a ‘gold standard’ because it is the only model of analysis proven valid for analyzing interactions between biologically active agents [24]–[28]. Briefly, doses of ZOL were plotted on the x -axis and doses of paclitaxel/cisplatin were plotted on the y -axis, and points representing equal effects on cell viability were connected to obtain an isobologram.…”

Section: Methodsmentioning

confidence: 99%

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Reactive Oxygen Species and Autophagy Associated Apoptosis and Limitation of Clonogenic Survival Induced by Zoledronic Acid in Salivary Adenoid Cystic Carcinoma Cell Line SACC-83

Yang

Jiang

et al. 2014

PLoS ONE

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Salivary adenoid cystic carcinoma is an epithelial tumor in the head and neck region. Despite its slow growth, patients with salivary adenoid cystic carcinoma exhibit poor long term survival because of a high rate of distant metastasis. Lung and bone are common distant metastasis sites. Zoledronic acid, a third generation bisphosphonate, has been used for tumor-induced osteolysis due to bone metastasis and has direct antitumor activity in several human neoplasms. Here, we observed that zoledronic acid inhibited salivary adenoid cystic carcinoma cell line SACC-83 xenograft tumor growth in nude mice. In vitro, zoledronic acid induced apoptosis and reduced clonogenic survival in SACC-83. Flow cytometry and western blotting indicated that the cell cycle was arrested at G0/G1. Zoledronic acid treatment upregulated reactive oxygen species as well as the autophagy marker protein LC-3B. Reactive oxygen species scavenger N-acetylcysteine and autophagy antagonist 3-methyladenine decreased zoledronic acid-induced apoptosis and increased clonogenic survival. Silencing of the autophagy related gene Beclin-1 also decreased zoledronic acid-induced apoptosis and inhibition of clonogenic formation. In addition, isobolographic analysis revealed synergistic effects on apoptosis when zoledronic acid and paclitaxel/cisplatin were combined. Taken together, our results suggest that zoledronic acid induced apoptosis and reduced clonogenic survival via upregulation of reactive oxygen species and autophagy in the SACC-83 cell line. Thus, zoledronic acid should be considered a promising drug for the treatment of salivary adenoid cystic carcinoma.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Reactive Oxygen Species and Autophagy Associated Apoptosis and Limitation of Clonogenic Survival Induced by Zoledronic Acid in Salivary Adenoid Cystic Carcinoma Cell Line SACC-83

Yang

Jiang

et al. 2014

PLoS ONE

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“…However, another possible explanation for the increased expression of AT1 receptor mRNA relates to immunohistochemical observations showing that the AT1 receptor is found in axonal fibers and terminals in lamina II of the dorsal horn (Ahmad et al, 2003). Lamina II is the site of termination for nociceptive fibers and there is precedence for a role of angiotensin II in modulating pain pathways-centrally administered angiotensin II attenuates morphineinduced analgesia in mice and rats (Han et al, 2000;Kaneko et al, 1985). Moreover, studies that have examined whether endogenous opioids are operative in modulating the CNS action of angiotensin II (ang II) on blood pressure have shown that endogenous opioids modulate the pressor response to intracerebral ang II and that this effect is mediated mainly through endogenous kappa opioid receptors (Rabkin, 2007).…”

Section: Decreased Opioid Receptor Expressionmentioning

confidence: 99%

Decreased spinal cord opioid receptor mRNA expression and antinociception in a Theiler's murine encephalomyelitis virus model of multiple sclerosis

et al. 2008

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Multiple sclerosis patients typically experience increased pain that is relatively insensitive to opiate treatment. The mechanistic basis for this increased nociception is currently poorly understood. In the present study, we utilized the Theiler's murine encephalomyelitis virus (TMEV) model of MS to examine possible changes in spinal cord opioid receptor mRNA over the course of disease progression. TMEV infection led to significantly decreased mu, delta and kappa opioid receptor mRNA expression as analyzed by quantitative real-time PCR in both male and female mice at days 90, 150 and 180 post-infection (PI). Since opioid receptor mRNA expression decreased in TMEV mice, we examined whether opiate analgesia is also altered. TMEV infected female mice had significantly decreased opiate analgesia in thermal nociceptive tests beginning at day 90 PI, while TMEV-infected male mice did not display significantly decreased opiate analgesia until day 120 PI. The novel finding that opioid receptor expression is significantly decreased in the spinal cord of TMEV mice could explain the increased nociception and loss of opiate analgesia observed in both TMEV mice and multiple sclerosis patients.

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“…A variety of other receptors, enzymes and cytokines that play a role in the modulation of pain and inflammation have been identified and are being researched as potential targets for novel analgesics. These include, but are not limited to, angiotensin II, glycine, glutamate, GABA and protein kinase [155,[457][458][459][460][461][462][463][464][465][466][467][468][469][470][471][472][473][474]. A detailed discussion of this literature to date is beyond the scope of this review.…”

Section: Other Potential Targetsmentioning

confidence: 99%

Analgesia for Sheep in Commercial Production: Where to Next?

Small

Fisher

et al. 2021

Animals

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Increasing societal and customer pressure to provide animals with ‘a life worth living’ continues to apply pressure on livestock production industries to alleviate pain associated with husbandry practices, injury and illness. Over the past 15–20 years, there has been considerable research effort to understand and develop mitigation strategies for painful husbandry procedures in sheep, leading to the successful launch of analgesic approaches specific to sheep in a number of countries. However, even with multi-modal approaches to analgesia, using both local anaesthetic and non-steroidal anti-inflammatory drugs (NSAID), pain is not obliterated, and the challenge of pain mitigation and phasing out of painful husbandry practices remains. It is timely to review and reflect on progress to date in order to strategically focus on the most important challenges, and the avenues which offer the greatest potential to be incorporated into industry practice in a process of continuous improvement. A structured, systematic literature search was carried out, incorporating peer-reviewed scientific literature in the period 2000–2019. An enormous volume of research is underway, testament to the fact that we have not solved the pain and analgesia challenge for any species, including our own. This review has highlighted a number of potential areas for further research.

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Synergistic effect of cholecystokinin octapeptide and angiotensin II in reversal of morphine induced analgesia in rats

Cited by 19 publications

References 19 publications

Reactive Oxygen Species and Autophagy Associated Apoptosis and Limitation of Clonogenic Survival Induced by Zoledronic Acid in Salivary Adenoid Cystic Carcinoma Cell Line SACC-83

Reactive Oxygen Species and Autophagy Associated Apoptosis and Limitation of Clonogenic Survival Induced by Zoledronic Acid in Salivary Adenoid Cystic Carcinoma Cell Line SACC-83

Decreased spinal cord opioid receptor mRNA expression and antinociception in a Theiler's murine encephalomyelitis virus model of multiple sclerosis

Analgesia for Sheep in Commercial Production: Where to Next?

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