1992
DOI: 10.1098/rspb.1992.0002
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Synergistic effect ofAdhalleles inDrosophila melanogaster

Abstract: In laboratory cultures of Drosophila melanogaster derived from an African population, the quantities of six out of seven enzymes (G6PD, IDH, GPDH, ME, MDH, PGM and ADH) were higher in Adh-FF homozygotes than they were in Adh-SS. In crosses between Adh-FF and Adh-SS flies, the differences segregated as co-dominant alleles of a single Mendelian gene closely linked, or identical, to the Adh locus. The generality of these associations was suggested by the study of a French population with a very different history … Show more

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Cited by 3 publications
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“…MDH is involved in the malateaspartate shuttle. ADH and GPDH activities covary under both ethanol and glycerol exposure (Khan et al 1996) and synergistic activity variation between ADH genotypes and GPDH and MDH activities have been reported (Li 1992). A common genetic response to ethanol exposure in population cages has also been reported for these three genes and their allozyme polymorphisms (Cavener and Clegg 1981).…”
Section: Discussionmentioning
confidence: 90%
“…MDH is involved in the malateaspartate shuttle. ADH and GPDH activities covary under both ethanol and glycerol exposure (Khan et al 1996) and synergistic activity variation between ADH genotypes and GPDH and MDH activities have been reported (Li 1992). A common genetic response to ethanol exposure in population cages has also been reported for these three genes and their allozyme polymorphisms (Cavener and Clegg 1981).…”
Section: Discussionmentioning
confidence: 90%