Synergistic effect of low K and D vitamin status on arterial stiffness in a general population

Mayer, Otto; Seidlerová, Jitka; Wohlfahrt, Peter; Filipovský, Jan; Cífková, Renata; Černá, Václava; Kučerová, Alena; Pešta, Martin; Fuchsova, Radka; Topolčan, Ondřej; Jardon, Kelly M; Drummen, Nadja E.A.; Vermeer, Cees

doi:10.1016/j.jnutbio.2017.04.010

Cited by 17 publications

(12 citation statements)

References 50 publications

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“…O’Connor et al provided evidence that 25(OH)D deficiency was associated with lower serum uncarboxylated osteocalcin and lower bone mineral content in Danish girls, although a vitamin D supplement did not increase serum osteocalcin (400 IU/day for 12 months) [76]. In a cross-sectional study, Mayer et al noticed that insufficient 25(OH)D levels were associated with higher serum levels of dephospho-uncarboxylated matrix γ-carboxyglutamate protein, and thus were associated with higher aortic pulse wave velocity and aortic stiffness, and the polymorphism of vitamin D receptor (GG phenotype) along with vitamin K deficiency predicted higher aortic pulse wave velocity [77]. Because deficiencies of vitamins D and K play a conjunctive role in osteoporosis and vitamin K-dependent protein metabolism, vitamin D or K supplementation could alleviate vascular calcification in CKD patients.…”

Section: Introductionmentioning

confidence: 99%

Emerging Role of Vitamins D and K in Modulating Uremic Vascular Calcification: The Aspect of Passive Calcification

Hou

Zheng

et al. 2019

Nutrients

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Vascular calcification is a critical complication in patients with chronic kidney disease (CKD) because it is predictive of cardiovascular events and mortality. In addition to the traditional mechanisms associated with endothelial dysfunction and the osteoblastic transformation of vascular smooth muscle cells (VSMCs), the regulation of calcification inhibitors, such as calciprotein particles (CPPs) and matrix vesicles plays a vital role in uremic vascular calcification in CKD patients because of the high prevalence of vitamin K deficiency. Vitamin K governs the gamma-carboxylation of matrix Gla protein (MGP) for inhibiting vascular calcification, and the vitamin D binding protein receptor is related to vitamin K gene expression. For patients with chronic kidney disease, adequate use of vitamin D supplements may play a role in vascular calcification through modulation of the calciprotein particles and matrix vesicles (MVs).

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Section: Introductionmentioning

confidence: 99%

Emerging Role of Vitamins D and K in Modulating Uremic Vascular Calcification: The Aspect of Passive Calcification

Hou

Zheng

et al. 2019

Nutrients

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“…Moreover, pulse wave velocity was independently associated with both dp-ucMGP and 25-OH-D3. The authors concluded that a deficiency of both vitamin K and D might act synergistically to promote arterial stiffness [ 34 ]. In CKD patients, subclinical deficiency of vitamin D and K status (assessed by circulating dp-ucMGP and 25-OH-D, respectively) was highly prevalent and associated with albuminuria and CKD stage [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

The Association of dp-ucMGP with Cardiovascular Morbidity and Decreased Renal Function in Diabetic Chronic Kidney Disease

Roumeliotis

Στάμου

et al. 2020

IJMS

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We aimed to investigate the possible association of the inactive, dephosphorylated, uncarboxylated matrix Gla protein (dp-ucMGP) with oxidized low-density lipoprotein (ox-LDL) and all-cause/cardiovascular (CV) mortality and renal function in diabetic chronic kidney disease (CKD). Ox-LDL and dp-ucMGP were determined in 66 diabetic CKD patients. All patients were prospectively followed for seven years, or until the occurrence of death, or a composite renal outcome of 30% estimated glomerular filtration rate (eGFR) reduction or progression to end-stage renal disease (ESRD) requiring dialysis occurred. Secondary outcomes were the occurrence of CV events. Kaplan–Meier curves showed that patients with plasma dp-ucMGP levels above the median (≥656 pM) had a significantly higher risk for all study endpoints. After adjustment for several well-known cofounders, multivariate Cox analysis showed that high plasma dp-ucMGP levels were associated with all-cause mortality (Hazard ratio-HR = 2.63, 95% Confidence Interval-CI = 1.17–5.94, p = 0.02), CV mortality (HR = 2.82, 95% CI = 1.07–7.49, p = 0.037) and progression of CKD (HR = 4.02, 95% CI = 1.20–13.46, p = 0.024). Circulating dp-ucMGP is associated with mortality and decreased renal function in diabetic CKD.

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“…Animal and human studies suggest that optimal concentrations of both vitamin D and vitamin K are beneficial for bone and cardiovascular health [6,7,8]. Previous studies have suggested joint associations to vitamin D and K status, with incident hypertension and arterial stiffness among general populations [9,10]. Recent evidence also indicates that vitamin D promotes the production of vitamin K-dependent proteins [11].…”

Section: Introductionmentioning

confidence: 99%

Effect of 6-Month Vitamin D Supplementation on Plasma Matrix Gla Protein in Older Adults

et al. 2019

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Vitamin D supplementation has been widely promoted to restore 25-hydroxyvitamin D concentrations; however, experimental evidence suggests a nutrient interaction with vitamin K. We assessed the effects of 1200 IU vitamin D3 per day versus placebo for six months on vitamin K status in a randomized, double-blind, placebo-controlled trial with participants aged 60–80 years with depressive symptoms and ≥1 functional limitation for a secondary analysis. Stored baseline and six-month follow-up blood samples were available for 131 participants (n = 65 placebo vs. n = 66 vitamin D supplementation). We measured dephosphorylated uncarboxylated matrix gla protein (MGP) (dp-ucMGP) concentrations—a marker of vitamin K deficiency. Mean age was 68 years, and 89 participants (68%) were women. Vitamin K antagonists were used by 16 participants and multivitamin supplements by 50 participants. No differences in change between intervention and placebo were found (−38.5 ± 389 vs. 4.5 ± 127 (pmol/L), p = 0.562). When excluding vitamin K antagonist users and multivitamin users, dp-ucMGP at follow-up was significantly higher in the vitamin D group (n = 40) compared to placebo (n = 30), with a difference of 92.8 (5.7, 180) pmol/L, adjusting for baseline dp-ucMGP and sex. In conclusion, vitamin D supplementation for six months did not affect vitamin K status; however, among participants without vitamin K antagonist or multivitamin use, vitamin D supplementation influenced dp-ucMGP concentrations.

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Synergistic effect of low K and D vitamin status on arterial stiffness in a general population

Cited by 17 publications

References 50 publications

Emerging Role of Vitamins D and K in Modulating Uremic Vascular Calcification: The Aspect of Passive Calcification

Emerging Role of Vitamins D and K in Modulating Uremic Vascular Calcification: The Aspect of Passive Calcification

The Association of dp-ucMGP with Cardiovascular Morbidity and Decreased Renal Function in Diabetic Chronic Kidney Disease

Effect of 6-Month Vitamin D Supplementation on Plasma Matrix Gla Protein in Older Adults

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