Synergistic effect of lycopene and tocopherol against oxidative stress and mammary tumorigenesis induced by 7,12-dimethyl[<i>a</i>]benzanthracene in female rats

Al-Malki, Abdulrahman L.; Moselhy, Said S; Refai, Mohammed Y.

doi:10.1177/0748233711416948

Cited by 24 publications

(13 citation statements)

References 37 publications

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“…Lycopene has 11 conjugated double bonds and has the most efficient quenching activity among biological carotenoids (15). Previous studies reported that elevated serum lipid peroxide levels induced by 2,7-dimethyl(a)benzanthracene in SD female rats were significantly reduced by a diet supplemented with approximately 50 ppm lycopene for 90 or 120 d, compared with a non-treated group (33,34). In the present study, serum lycopene concentrations in the lycopene intake groups were undetectable by the analytical methods used.…”

Section: Discussionmentioning

confidence: 99%

Lycopene Intake Facilitates the Increase of Bone Mineral Density in Growing Female Rats

Iimura¹,

Agata²,

Takeda³

et al. 2014

J Nutr Sci Vitaminol

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Section: Discussionmentioning

confidence: 99%

Lycopene Intake Facilitates the Increase of Bone Mineral Density in Growing Female Rats

Iimura¹,

Agata²,

Takeda³

et al. 2014

J Nutr Sci Vitaminol

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“…2,24 En este trabajo se utilizó el anión superóxido como marcador de oxidación por ser precursor de otras especies reactivas oxidantes, y por su capacidad de responder a factores ambientales y nutricionales. 4,9,11 Existen datos preclínicos que sugieren actividad antioxidante de los carotenoides no provitamínicos, 25 pero la evidencia en seres humanos no es concluyente. 26 Esto concuerda con la falta de asociación significativa hallada en la presente investigación, entre el consumo de éstos y el nivel de superóxido, al ajustar por edad, estado nutricional y nivel de actividad física.…”

Section: Discussionunclassified

Modificaciones en el nivel de anión superóxido en leche materna, según la ingesta de flavonoides y carotenoides

et al. 2017

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“…Similarly, synergistic inhibition of oxidative stress in a mouse tumor model [40] or inhibition of androgen signaling and PSA secretion by lycopene and tocopherol [41] was determined. In addition, the synergistic effect of a TNC and carnosic acid (from rosemary) has recently been observed on inhibition of UVB-induced IL6 secretion in keratinocytes as compared to the single interventions (Calniquer et al, unpublished data).…”

Section: Resultsmentioning

confidence: 99%

Tomato Phytonutrients Balance UV Response: Results from a Double-Blind, Randomized, Placebo-Controlled Study

Groten

Marini

Jaenicke

et al. 2019

Skin Pharmacol Physiol

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Background: Our previous double-blinded, placebo-controlled cross-over study indicated that a nutritional supplement named lycopene-rich tomato nutrient complex (TNC) can protect from UVA1-induced (340–400 nm) and UVA- (320–400 nm)/UVB-induced (280–320 nm) upregulation of molecular markers associated with oxidative stress, inflammation, and ageing. Objectives: in the current double-blind, randomized, placebo-controlled multicenter study, we analyze whether a similar, synergistic carotenoid-rich TNC can protect from broadband UVB-induced threshold erythema formation assessed as increase in minimal erythemal dose (MED) reading, the intensity of erythema formation, and the upregulation of molecular markers associated with inflammation and immunosuppression, and whether this correlates with carotenoid blood levels. Methods: One hundred and forty-nine healthy volunteers were randomized to two groups and subjected to a 5-week washout phase, followed by a 12-week treatment phase receiving either 15 mg lycopene, 5.8 mg phytoene and phytofluene, 0.8 mg β-carotene, 5.6 mg tocopherols from tomato extract, and 4 mg carnosic acid from rosemary extract per day or placebo made from medium-chain triglycerides. At the end of each phase, MED determination, UVB irradiation, chromametry, biopsies, and blood samples were undertaken. Results: The active supplement was well tolerated. Interestingly, no significant difference was seen in the MED between the active-supplement and placebo groups, as determined by visual grading by expert assessors. Of note, the carotenoid-containing supplement significantly protected against UVB-induced erythema formation measured as Δa* after the intervention minus Δa* after the washout phase as compared to the placebo. Moreover, intake of the active supplement significantly protected against UVB-induced upregulation of IL6 and TNFα as compared with the intake of placebo. Lastly, carotenoid plasma levels were significantly increased. Conclusion: This well-tolerated carotenoid-containing supplement significantly protected against UVB-induced erythema formation and upregulation of proinflammatory cytokines in healthy volunteers.

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Synergistic effect of lycopene and tocopherol against oxidative stress and mammary tumorigenesis induced by 7,12-dimethyl[a]benzanthracene in female rats

Cited by 24 publications

References 37 publications

Lycopene Intake Facilitates the Increase of Bone Mineral Density in Growing Female Rats

Lycopene Intake Facilitates the Increase of Bone Mineral Density in Growing Female Rats

Modificaciones en el nivel de anión superóxido en leche materna, según la ingesta de flavonoides y carotenoides

Tomato Phytonutrients Balance UV Response: Results from a Double-Blind, Randomized, Placebo-Controlled Study

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