Synergistic Effect of Metal Nanoparticles on the Antimicrobial Activities of Antibiotics against Biorecycling Microbes

Khurana, Chandni; Sharma, Purnima; Pandey, O.P.; Chudasama, Bhupendra

doi:10.1016/j.jmst.2016.02.004

Cited by 59 publications

(37 citation statements)

References 28 publications

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“…The challenge is to tune such geometric parameters of AgNPs, in nanometer scale, to control their antimicrobial effects. [17][18][19][20] Chitosan is a biodegradable and biocompatible copolymer of N-acetyl-D-glucosamine and D-glucosamine that presents antimicrobial activity. Such macromolecules showed high capacity to stabilize and prevent aggregation of AgNPs in aqueous medium, due to the strong coordinative interaction involving amine groups and silver atoms.…”

Section: Introductionmentioning

confidence: 99%

Synergism in the Antibacterial Action of Ternary Mixtures Involving Silver Nanoparticles, Chitosan and Antibiotics

Brasil¹,

Filgueiras²,

Campos³

et al. 2018

J. Braz. Chem. Soc.

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The investigations of the antibacterial actions, observed in ternary associations involving silver nanoparticles (AgNPs), chitosan and the antibiotics azithromycin (AZ), levofloxacin (LE) or tetracycline (TE), against Gram-negative and Gram-positive bacterial strains, were performed by in vitro antimicrobial susceptibility testing and checkerboard assays. The pH impact in the culture medium was carefully discarded, but preserving the best conditions for solubilizing chitosan. The synergistic antibacterial effects were observed in the most combinations of AgNPs, chitosan and antibiotic, leading to a reduction from 37 to 97% in the minimum inhibitory concentration of the drugs. The mechanisms for the enhanced antimicrobial effects were proposed based on the investigations of the adsorptions of the drugs on the silver surfaces through surface-enhanced Raman scattering (SERS) spectroscopy.

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Section: Introductionmentioning

confidence: 99%

Synergism in the Antibacterial Action of Ternary Mixtures Involving Silver Nanoparticles, Chitosan and Antibiotics

Brasil¹,

Filgueiras²,

Campos³

et al. 2018

J. Braz. Chem. Soc.

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show abstract

“…AgNPs do not have a specific bactericidal effect, so the risk of development of resistance is not as high as for antibiotics. (23,(35)(36)(37)(38). Strain specificity has been observed for different microorganisms (35,39) and more pronounced effect was observed against Gramnegative bacteria in comparison to that against Grampositive bacteria (18).…”

Section: Agnpsmentioning

confidence: 95%

Nanoantibiotics Future nanotechnologies to combat antibiotic resistance

et al. 2018

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The discovery of antibiotics was hailed as a historic breakthrough for the human race in the fight against bacterial and malignant infections. However, in a very short time, owing to their acute and aggressive nature, bacteria have developed resistance against antibiotics and other chemotherapeutics agents. Potentially, this situation could again result in bacterial infection outbreaks. Metal and metal oxide nanoparticles have been proven as better alternatives; the combination of antibiotics and metal oxide nanoparticles was shown to decrease the toxicity and enhance the antibacterial, antiviral, and anticancer efficacy of the agents. This review provides a detailed view about the role of metal and metal oxide nanoparticles in the treatment of infections in conjunction with antibiotics, their modes of action, and synergism. In addition, the problems of multidrug resistance are addressed and will allow the development of a comprehensive, reliable, and rational treatment plan. It is expected that this comprehensive review will lead to new research opportunities, which should be helpful for future applications in biomedical science.

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“…Finally, the use of more than one agent broadens the antibacterial spectrum of the empirical therapy and thus ensures that at least one agent will cover the infecting organism (Gurjar et al, 2014). such as gold (El-Sheekh and El Kassas, 2014;Kalita et al, 2016;Al-Mawlawi and Obaid, 2019;Arya et al, 2019;Nishanthi et al, 2019;Yang et al, 2019), copper (Khurana et al, 2016;Woźniak-Budych et al, 2017;Murugan, 2018;Selvaraj et al, 2019), and zinc (Banoee et al, 2010;Bhande et al, 2013) have been used in combination with a variety of antibiotic families to enhance bactericidal efficacy.…”

Section: Metal Nanoparticle-based Combinatorial Treatmentsmentioning

confidence: 99%

“…They can be used in combinatorial treatments with currently used antibiotics for enhanced antimicrobial activity ( Shahverdi et al, 2007 ; Kora and Rastogi, 2013 ; Naqvi et al, 2013 ; Singh et al, 2013 ; Panácek et al, 2016 ; Lopez-Carrizales et al, 2018 ; Perveen et al, 2018 ; Vazquez-Muñoz et al, 2019 ). Nonetheless, some other MNPs such as gold ( El-Sheekh and El Kassas, 2014 ; Kalita et al, 2016 ; Al-Mawlawi and Obaid, 2019 ; Arya et al, 2019 ; Lee and Lee, 2019 ; Nishanthi et al, 2019 ; Yang et al, 2019 ), copper ( Khurana et al, 2016 ; Woźniak-Budych et al, 2017 ; Murugan, 2018 ; Selvaraj et al, 2019 ), and zinc ( Banoee et al, 2010 ; Bhande et al, 2013 ) have been used in combination with a variety of antibiotic families to enhance bactericidal efficacy.…”

Section: The New Therapeutic Alternatives: Input From Recent Studiesmentioning

confidence: 99%

The Demand for New Antibiotics: Antimicrobial Peptides, Nanoparticles, and Combinatorial Therapies as Future Strategies in Antibacterial Agent Design

et al. 2020

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Synergistic Effect of Metal Nanoparticles on the Antimicrobial Activities of Antibiotics against Biorecycling Microbes

Cited by 59 publications

References 28 publications

Synergism in the Antibacterial Action of Ternary Mixtures Involving Silver Nanoparticles, Chitosan and Antibiotics

Synergism in the Antibacterial Action of Ternary Mixtures Involving Silver Nanoparticles, Chitosan and Antibiotics

Nanoantibiotics Future nanotechnologies to combat antibiotic resistance

The Demand for New Antibiotics: Antimicrobial Peptides, Nanoparticles, and Combinatorial Therapies as Future Strategies in Antibacterial Agent Design

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