2022
DOI: 10.3389/fmed.2022.900784
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Synergistic effect of microneedle-delivered extracellular matrix compound and radiofrequency on rejuvenation of periorbital wrinkles

Abstract: BackgroundA combination of minimally invasive modalities can induce collagen regeneration more quickly and promote the penetration of topical agents, thus promoting skin rejuvenation. In this study, we aimed to investigate the synergistic efficacy of extracellular matrix compound (ECM-C) via microneedle (MN) and radiofrequency (RF) on periorbital wrinkles.MethodA total of 25 participants with periorbital wrinkles were selected for this study. The left and right side of the periorbital area was randomly given E… Show more

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Cited by 3 publications
(2 citation statements)
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“…5,29 The same applies to the injection of soft tissue fillers or to microneedling with or without radiofrequency as well as to tranexamic acid mesotherapy. [30][31][32][33][34] Periocular rhytidolysis by subcision with the wire scalpel has also been described 35 same as the use of monofilament dermal threads. 36 Topical application of various preparations, as well as topical adhesive pads have also been reported without much convincing high efficacy.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…5,29 The same applies to the injection of soft tissue fillers or to microneedling with or without radiofrequency as well as to tranexamic acid mesotherapy. [30][31][32][33][34] Periocular rhytidolysis by subcision with the wire scalpel has also been described 35 same as the use of monofilament dermal threads. 36 Topical application of various preparations, as well as topical adhesive pads have also been reported without much convincing high efficacy.…”
Section: Discussionmentioning
confidence: 99%
“…Various skin-resurfacing modalities have been proposed; though they may correct minor surface irregularities, they do not change mimetic behavior of the facial muscles nor do they influence gravitational forces thus their effectiveness has been limited 5,29 . The same applies to the injection of soft tissue fillers or to microneedling with or without radiofrequency as well as to tranexamic acid mesotherapy 30–34 . Periocular rhytidolysis by subcision with the wire scalpel has also been described 35 same as the use of monofilament dermal threads 36 .…”
Section: Discussionmentioning
confidence: 99%