Synergistic effect of MTHFR C677T and F2 G20210A polymorphisms on ischemic stroke

They-They, Thierry Paluku; Battas, Omar; Nadifi, Sellama

doi:10.1007/s12264-013-1381-4

Cited by 9 publications

(8 citation statements)

References 36 publications

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“…Twenty-three studies focusing on IS in all age groups revealed an average age ranging from 49 ± 15.2 to 67.3 ± 9.9 years old. Thus, the average age is listed in the fifth and sixth decade [13, 15–18, 20, 21, 23–28, 32–41]. However, two studies did not specify the average age of patients.…”

Section: Resultsmentioning

confidence: 99%

Ischemic stroke in Morocco: a systematic review

et al. 2019

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BackgroundThe aim of this systematic review is to determine the epidemiological and etiological profiles, the influential factors of the prehospital delay, thrombolysis management, the acute and 3-month mortality rate and the genetic aspect of ischemic stroke in Morocco.MethodsThe present work is a systematic review that was conducted according to the recommendations of the “Preferred reporting items for systematic reviews and meta-analysis”. We used Pubmed, Sciencedirect, Scopus, Clinicalkey, and Google scholar databases for the raking of the gray literature during the time frame 2009 and 2018. The protocol of the review was registered in the PROSPERO register (CRD42018115206).These studies were analyzed based on: Age, sex ratio, risk factors, etiological profile according to Trial of ORG classification 10,172 in Acute Stroke Treatment, prehospital delay average and its influential factors, thrombolyzed patients’ proportion, acute and 3-month mortality and the genetic factors of ischemic stroke in Morocco.ResultsTwenty-nine (n = 29) studies were selected. The average age ranged from 49 ± 15.2 to 67.3 ± 9.9 years old. Moreover, we reported male predominance within all ages in 13 studies. High blood pressure, diabetes, smoking and heart disease were the four identified main risk factors by the prementioned studies. Atherosclerosis and cardioembolic were the main described etiologies of cerebral ischemia, and the average prehospital time ranged from 26 to 61.9 h. The proportion of thrombolysed patients ranged from 1.8% to 2.9%, the mortality rate varied in the acute phase from 3 to 13%, and the 3-month mortality ranged from 4.3 to 32.5%. It is also important to highlight that most of these studies, which were conducted in hospital environment, have a reduced sample size and no confidence interval.ConclusionsIschemic stroke is affecting more likely the young population with male predominance. Moreover, the long prehospital delay and the low proportion of thrombolysed patients are alarming. This indicates the need to investigate in depth the key factors influencing the access to care for Moroccan patients in order to improve the management of this neurologic deficit in Morocco.

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Section: Resultsmentioning

confidence: 99%

Ischemic stroke in Morocco: a systematic review

et al. 2019

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“…In our study, we found that three MTHFR gene polymorphisms were not significantly associated with hypertension. Many genetic studies have shown that genetic variants in the MTHFR gene have been linked to CVDs, such as coronary heart disease [28,29], type 2 diabetes [30,31], ischemic stroke [32,33] and hypertension [34,35], but the clear mechanisms need to be further investigated. Markan et al [36] reported that MTHFR rs1801133 and rs1801131 alleles and the co-occurrence of rs1801133 CT/rs1801131 CC genotypes were linked to increased risk of hypertension in the Indian population.…”

Section: Discussionmentioning

confidence: 99%

Association of single nucleotide polymorphisms of MTHFR, TCN2, RNF213 with susceptibility to hypertension and blood pressure

Liu

et al. 2019

Bioscience Reports

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Methylenetetrahydrofolate reductase gene (MTHFR), transcobalaminII (TCN2) and ring finger protein 213 (RNF213) are related to homocysteine (Hcy) level and are of great significance for hypertension. We aimed to evaluate the associations of MTHFR (rs1801133, rs1801131, rs9651118), TCN2 (rs117353193) and RNF213 (rs9916351) with hypertension and blood pressure (BP). A total of 953 patients with hypertension and 1103 controls were enrolled. Genotyping was performed by Taqman. Logistic regression analysis indicated that A allele of TCN2 rs117353193 under the dominant model had a significantly protective effect (P=0.045) after adjustment, which showed that AA+GA genotype has a lower risk than GG. Additionally, the average diastolic BP (DBP) (P=0.044) and mean arterial pressure (MAP) (P=0.035) levels were significantly different between genotypes of RNF213 rs9916351. Further pairwise comparison showed that the average systolic BP (SBP) level of the TT genotype carriers were significantly higher than in CC (P=0.024), and the average DBP and MAP levels of the TT genotype carriers were higher than in CT (P=0.044, P=0.012, respectively) and CC (P=0.048, P=0.010, respectively). In the recessive model, the average SBP (P=0.043), DBP (P=0.018) and MAP (P=0.017) levels with the TT genotype carriers were significantly higher than in CT+CC. Multiple linear regression analysis suggested that RNF213 rs9916351 in the recessive model had significant effects on SBP (P=0.025), DBP (P=0.017) and MAP (P=0.010) as a risk factor. However, no associations were observed between MTHFR and hypertension. TCN2 rs117353193 might serve as a protective factor in hypertension, and RNF213 rs9916351 might be a risk factor that is linked to increase BP level in Northeast Chinese population.

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“…Водночас у цілій низці праць не було доведено прямого впливу C677T-поліморфізму на розвиток ішемічних уражень головного мозку. Такі дані, зокрема, одержано в Індії [33], Туреччині [34], Марокко [35].…”

Section: результати та їх обговоренняunclassified

Analysis of the effect of N5, N10-methylenetetrahydrofolate reductase gene C(677)-->T polymorphism on the ischemic stroke development in persons with various risk factors

Harbuzova¹,

Polonikov²,

Stroi³

et al. 2014

Fiziol Zh

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за χ 2-критерієм). Гомозиготи TT мають більшу ймовірність розвитку ІАТІ, ніж носії основного С-алеля (СT+СС) (OR=2,3, CI=0,911-5,449, P=0,049). У представників української популяції існує зв'язок між частотою генотипів за поліморфізмом C 677 T гена MTHFR і ризиком ІАТІ. Цей зв'язок проявляється у пацієнтів чоловічої статі, в осіб з нормальним артеріальним тиском і в людей, що не мають звички куріння. Стать пацієнтів, індекс маси тіла, значення артеріального тиску і куріння впливають на рівень асоціації вивченого поліморфізму з інсультом.

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Synergistic effect of MTHFR C677T and F2 G20210A polymorphisms on ischemic stroke

Cited by 9 publications

References 36 publications

Ischemic stroke in Morocco: a systematic review

Ischemic stroke in Morocco: a systematic review

Association of single nucleotide polymorphisms of MTHFR, TCN2, RNF213 with susceptibility to hypertension and blood pressure

Analysis of the effect of N5, N10-methylenetetrahydrofolate reductase gene C(677)-->T polymorphism on the ischemic stroke development in persons with various risk factors

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