Synergistic effect of sevoflurane and isoflurane on inhibition of the adult-type muscle nicotinic acetylcholine receptor by rocuronium

Liu, Li; Li, Wei; Wei, Ke; Cao, Jian; Luo, Jie; Wang, Bin; Min, Su

doi:10.1007/s00540-012-1527-y

Cited by 4 publications

(4 citation statements)

References 26 publications

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“…It is noteworthy that volatile anaesthetics reduce ischemic brain damage and improve the neurologic outcome (Brosnan and Thiesen 2012; Ding et al 2009; Liu et al 2013; Mackay et al 2006; Schefold et al 2009). They stabilise cerebral blood flow, improve ischemia-injured blood–brain barrier integrity and stabilise cell membranes in brain tissue and reduce glial damage (Ding et al 2009; Heyes et al 1992; Schefold et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Plasma Kynurenic Acid Concentration in Patients Undergoing Cardiac Surgery: Effect of Anaesthesia

Kotlińska-Hasiec

Nowicka-Stążka

Parada-Turska

et al. 2014

Arch. Immunol. Ther. Exp.

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Increases in plasma kynurenic acid (KYNA) concentration relate to the severity of inflammation. The aim of this study was to analyse changes in plasma KYNA concentration and neutrophil/lymphocyte ratio (NLR) in cardiac surgery patients. Additionally, the effect of anaesthesia was analysed. Adult cardiac surgery patients under intravenous general anaesthesia were studied. Additionally, some patients received sevoflurane (SEV) prior to cardiopulmonary bypass. Plasma KYNA concentration and NLR were measured before anaesthesia, just after surgery and on postoperative days 1, 2 and 3. Patients were assigned to two groups: patients who did not receive SEV (NonSEV group) and patients who received SEV (SEV group). Forty-three patients were studied. Twenty-four of them received SEV. KYNA increased immediately after surgery and remained elevated through postoperative day 3 in the NonSEV group, whereas it was similar to the preoperative concentration in the SEV group. NLR increased immediately after surgery in both groups, and higher values were noted in the NonSEV group than in the SEV group at postoperative days 2 and 3. Plasma KYNA concentration correlated with NLR in the NonSEV group. Cardiac surgery caused an increase in NLR. Plasma KYNA increased in the NonSEV group and correlated with NLR. Administration of SEV inhibited the increase in KYNA, most likely due to its anti-inflammatory properties.

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Section: Discussionmentioning

confidence: 99%

Plasma Kynurenic Acid Concentration in Patients Undergoing Cardiac Surgery: Effect of Anaesthesia

Kotlińska-Hasiec

Nowicka-Stążka

Parada-Turska

et al. 2014

Arch. Immunol. Ther. Exp.

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“…Liu et al . [27] also reported that the inhibitory effect of rocuronium on the inward current of the adult mouse nAChR was enhanced by sevoflurane in a concentration-dependent manner. These in vitro studies showed that the co-application of sevoflurane significantly enhanced the inhibitory effects of NDMBAs [27, 41].…”

Section: Discussionmentioning

confidence: 99%

“…[27] also reported that the inhibitory effect of rocuronium on the inward current of the adult mouse nAChR was enhanced by sevoflurane in a concentration-dependent manner. These in vitro studies showed that the co-application of sevoflurane significantly enhanced the inhibitory effects of NDMBAs [27, 41]. Moreover, these studies demonstrated that a lower NDMBA concentration resulted in a stronger synergistic effect with sevoflurane [27, 41].…”

Section: Discussionmentioning

confidence: 99%

“…These in vitro studies showed that the co-application of sevoflurane significantly enhanced the inhibitory effects of NDMBAs [27, 41]. Moreover, these studies demonstrated that a lower NDMBA concentration resulted in a stronger synergistic effect with sevoflurane [27, 41]. It has been suggested that sevoflurane might potentiate the neuromuscular blockade of rocuronium by strengthening rocuronium pharmacodynamics at the neuromuscular junction, particularly at a lower rocuronium Cp.…”

Section: Discussionmentioning

confidence: 99%

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Effect of sevoflurane anesthesia on neuromuscular blockade produced by rocuronium infusion in dogs

Sakata

Ishikawa

Ishihara³

et al. 2019

The Journal of Veterinary Medical Science

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This study evaluated the effect of sevoflurane anesthesia on neuromuscular blockade with rocuronium in dogs. Six healthy beagle dogs were anesthetized four times with a minimum 14-day washout period. On each occasion, the dogs were administered 1.25-, 1.5-, 1.75-, or 2.0-fold of the individualized minimum alveolar concentration (MAC) of sevoflurane and received an infusion of rocuronium (0.5 mg/kg followed by 0.2 mg/kg/hr) for 120 min. Neuromuscular function was monitored with acceleromyography and train-of-four (TOF) stimulation of the left hind limb. Time to achieve TOF count 0 (onset time), time from the onset of neuromuscular blockade to the reappearance of TOF count 4 (blockade period), and time from the onset of rocuronium infusion to attaining a 70 or 90% TOF ratio (TOFR 70 or TOFR 90 ) were recorded. There were no significant differences in the onset time, blockade period, and plasma rocuronium concentration between the sevoflurane MAC multiples. The TOFR 70 and TOFR 90 were dose-dependently prolonged with the sevoflurane MAC multiples. There were significant differences in the TOFR 70 and TOFR 90 between the 1.25 sevoflurane MAC (median: 55 and 77.5 min, respectively) and 1.75 sevoflurane MAC (122.0 and 122.6 min; P =0.020 and P =0.020, respectively), 1.25 sevoflurane MAC and 2.0 sevoflurane MAC (126.0 and 131.4 min; P =0.020 and P =0.020), and 1.5 sevoflurane MAC (97.5 and 121.3 min) and 2.0 sevoflurane MAC ( P =0.033 and P =0.032). In dogs, sevoflurane anesthesia produced dose-dependent prolongation of recovery from neuromuscular blockade produced by rocuronium.

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Glial cell-derived neurotrophic factor alleviates sepsis-induced neuromuscular dysfunction by decreasing the expression of γ- and α7-nicotinic acetylcholine receptors in an experimental rat model of neuromyopathy

Wang

Min

Xie

et al. 2018

Biochemical and Biophysical Research Communications

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Synergistic effect of sevoflurane and isoflurane on inhibition of the adult-type muscle nicotinic acetylcholine receptor by rocuronium

Abstract: Residual-concentration sevoflurane or isoflurane has a strong synergistic effect with rocuronium at clinically relevant residual concentrations. A lower rocuronium concentration resulted in a stronger synergistic effect.

Cited by 4 publications

References 26 publications

Plasma Kynurenic Acid Concentration in Patients Undergoing Cardiac Surgery: Effect of Anaesthesia

Plasma Kynurenic Acid Concentration in Patients Undergoing Cardiac Surgery: Effect of Anaesthesia

Effect of sevoflurane anesthesia on neuromuscular blockade produced by rocuronium infusion in dogs

Glial cell-derived neurotrophic factor alleviates sepsis-induced neuromuscular dysfunction by decreasing the expression of γ- and α7-nicotinic acetylcholine receptors in an experimental rat model of neuromyopathy

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