Synergistic effect of tocotrienol-rich fraction (TRF25) of rice bran and lovastatin on lipid parameters in hypercholesterolemic humans

Qureshi, Asaf A.; Sami, Saeed A; Salser, Winston; Khan, Farooq Ahmad

doi:10.1016/s0955-2863(01)00144-9

Cited by 98 publications

(88 citation statements)

References 30 publications

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“…The utilisation of a mixture of tocotrienol and tocopherol, rather than a pure tocotrienol compound, could be the reason behind this observation. Although other human studies have demonstrated the benefit of this mixed fraction in lowering plasma lipids (Qureshi et al, 2001(Qureshi et al, , 2002, the fraction of tocopherol in the mixture used by them yielded a lower tocopherol fraction, compared to our TTMF (8% vs 26%, respectively).…”

Section: Discussioncontrasting

confidence: 65%

“…This is due to the inhibitory effect that tocotrienol has on HMGCoA reductase (Khor and Ng, 2000), the same enzyme that is inhibited by the statin group of drugs. Owing to their synergistic interaction, the combination of lovastatin and tocotrienol-rich fraction (TRF) has been shown to be effective in lowering plasma lipid parameters (Qureshi et al, 2001).OxLDL predisposes to inflammation (Bieghs et al, 2013) and endothelial dysfunction (Huang et al, 2013). In our study, we demonstrated that TTMF treatment had a neutral effect on hsCRP and TNF-, and a tendency for lowering of IL6 levels, thus proving to be potentially beneficial in quenching oxLDL-mediated inflammation.…”

Section: Tocotrienol-tocopherol and Vitamin C In Hypercholesterolaemimentioning

confidence: 64%

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Effects of adding tocotrienol-tocopherol mixed fraction and vitamin C on inflammatory status in hypercholesterolaemic patients in the low coronary risk category

et al. 2016

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Abstract-Aim:This study is designed to investigate the effects of tocotrienol-tocopherol mixed fraction (TTMF), vitamin C and combined TTMF-vitamin C supplementations on serum lipids and biochemical markers of inflammation and endothelial activation in hypercholesterolemic subjects in the low-risk category. Materials and Methods: 78 hypercholesterolaemic subjects (total cholesterol of  5.2 mmol/L and low-density lipoprotein 3.4 -4.9 mmol/L) in the low cardiovascular risk category according to the NCEP-ATP3 criteria were recruited. They were randomized into four treatment combination groups for a period of twelve months; (1) receiving TTMF and vitamin C, (2) receiving TTMF and placebo, (3) receiving vitamin C and placebo, and (4) receiving placebo for both. Serum fasting lipid profiles and levels of high-sensitivity C-reactive protein, interleukin-6, tumour necrosis factor-, intercellular adhesion molecule, vascular cell adhesion molecule, E-selectin and homocysteine were measured at entry and multiple time points post-randomisation. Results: There were no significant differences in percentage changes of lipid profiles and inflammatory markers between treated and placebo groups for either single or combined antioxidants supplementations. Conclusion: TTMF, vitamin C and combined TTMF-vitamin C supplementations have neutral effects on lipid profiles and biochemical markers of inflammation and endothelial activation in low risk subjects, suggesting that they offer no added advantage in the low cardiovascular risk group.

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Section: Discussioncontrasting

confidence: 65%

Section: Tocotrienol-tocopherol and Vitamin C In Hypercholesterolaemimentioning

confidence: 64%

Effects of adding tocotrienol-tocopherol mixed fraction and vitamin C on inflammatory status in hypercholesterolaemic patients in the low coronary risk category

et al. 2016

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“…None of the subjects reported any side-effects throughout the study of 25 weeks. 47 Consistent results were obtained using rice-bran derived TRF in another human study.…”

Section: Hypercholesterolemic Effectssupporting

confidence: 68%

Tocotrienols and its impact in cardiovascular health

Mishra

Badade²,

Lingidi³

et al. 2014

Int J Clin Trials

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“…There are also some data suggesting that high doses of γ-tocotrienol are partly converted to α-tocopherol [31]. As such, this may explain the effect seen in our study.…”

Section: A B C Dsupporting

confidence: 67%

Pure tocotrienol concentrate protected rat gastric mucosa from acute stress-induced injury by a non-antioxidant mechanism

Rodzian¹,

Ibrahim²,

Azlina³

2013

pjp

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Stress has been implicated as a risk factor of various major health problems, such as stress-induced gastric mucosal injury. This study was performed to investigate the action of a pure preparation of tocotrienol (T3) concentrate, made up of 90% δ-tocotrienol and 10% γ-tocotrienol, on gastric injury of rats induced by water-immersion restraint stress (WIRS). Fourteen male Sprague-Dawley rats (200-250 g) were divided into two equal groups: a control group and a treated group. The treatment group received T3 concentrate at 60 mg/kg body weight daily for 28 days. The body weights of rats were recorded daily before the treatment was given. At the end of the treatment period, all rats were subjected to WIRS for 3.5 hours, following which the rats were euthanized. The stomachs were isolated and opened along the greater curvature for the examination of lesions and measurements of gastric malondialdehyde (MDA) and prostaglandin E 2 (PGE 2 ) contents. The mean gastric mucosal lesion index in the treated rats was significantly lower than that in the control rats. This suggests that the T3 concentrate has the ability to confer protection to the gastric mucosa against gastric injury induced by acute stress. No significant difference was observed for changes in body weight before and after the treatment. The gastric PGE 2 content in both groups was comparable. However, the gastric MDA content was significantly higher in the treated group compared to the control group, indicating that the T3 supplementation was not able to reduce the lipid peroxidation process. This study concludes that the T3 concentrate has the ability to protect the gastric mucosa from stress-induced injury by a non-antioxidant mechanism.

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Synergistic effect of tocotrienol-rich fraction (TRF25) of rice bran and lovastatin on lipid parameters in hypercholesterolemic humans

Cited by 98 publications

References 30 publications

Effects of adding tocotrienol-tocopherol mixed fraction and vitamin C on inflammatory status in hypercholesterolaemic patients in the low coronary risk category

Effects of adding tocotrienol-tocopherol mixed fraction and vitamin C on inflammatory status in hypercholesterolaemic patients in the low coronary risk category

Tocotrienols and its impact in cardiovascular health

Pure tocotrienol concentrate protected rat gastric mucosa from acute stress-induced injury by a non-antioxidant mechanism

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