Synergistic effect of two antimicrobial peptides, Nisin and P10 with conventional antibiotics against extensively drug-resistant Acinetobacter baumannii and colistin-resistant Pseudomonas aeruginosa isolates

Jahangiri, Abolfazl; Neshani, Alireza; Mirhosseini, Seyed Ali; Ghazvini, Kiarash; Zare, Hosna; Sedighian, Hamid

doi:10.1016/j.micpath.2020.104700

Cited by 56 publications

(29 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several complications such as chronic skin and soft tissue infections which can complicate the clinical course of ulcers, diabetic foot infections, post-surgical infections, and burn wounds are characterized by a progressive worsening of their clinical outcome, when antibiotic-resistant pathogens are involved. Likewise, the Gram-negative bacterium A. baumannii has been reported as responsible for a variety of antibiotic-resistant infections such as wound, skin, and urinary tract infections, but also pneumonia and bacteremia [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Insect antimicrobial peptides: potential weapons to counteract the antibiotic resistance

Manniello

Moretta

Salvia

et al. 2021

Cell. Mol. Life Sci.

170

111

View full text Add to dashboard Cite

Misuse and overuse of antibiotics have contributed in the last decades to a phenomenon known as antibiotic resistance which is currently considered one of the principal threats to global public health by the World Health Organization. The aim to find alternative drugs has been demonstrated as a real challenge. Thanks to their biodiversity, insects represent the largest class of organisms in the animal kingdom. The humoral immune response includes the production of antimicrobial peptides (AMPs) that are released into the insect hemolymph after microbial infection. In this review, we have focused on insect immune responses, particularly on AMP characteristics, their mechanism of action and applications, especially in the biomedical field. Furthermore, we discuss the Toll, Imd, and JAK-STAT pathways that activate genes encoding for the expression of AMPs. Moreover, we focused on strategies to improve insect peptides stability against proteolytic susceptibility such as D-amino acid substitutions, N-terminus modification, cyclization and dimerization.

show abstract

Section: Introductionmentioning

confidence: 99%

Insect antimicrobial peptides: potential weapons to counteract the antibiotic resistance

Manniello

Moretta

Salvia

et al. 2021

Cell. Mol. Life Sci.

170

111

View full text Add to dashboard Cite

show abstract

“…As an example, Jangra and coworkers [ 35 ] tested the AMP Tridecaptin M together with rifampicin, vancomycin, clarithromycin, imipenem, and ceftazidime against several MDR A. baumannii strains and obtained FIC values ranging from 0.25 to 0.5 [ 35 ]. Jahangiri et al [ 36 ], proved that combination of the polycyclic peptide nisin with colistin gives rise to an additive effect against the resistant strains of A. baumannii used in their study, except for one strain against which a synergistic effect was observed (FIC = 0.5) [ 36 ]. Lately, Witherell and coworkers [ 37 ] showed a synergistic activity between the AMP CDP-B11 and colistin against several MDR Gram-negative bacteria, including A. baumannii .…”

Section: Discussionmentioning

confidence: 99%

The Antimicrobial Peptide Esc(1-21) Synergizes with Colistin in Inhibiting the Growth and in Killing Multidrug Resistant Acinetobacter baumannii Strains

et al. 2022

View full text Add to dashboard Cite

Multidrug-resistant microbial infections and the scarce availability of new antibiotics capable of eradicating them are posing a serious problem to global health security. Among the microorganisms that easily acquire resistance to antibiotics and that are the etiological cause of severe infections, there is Acinetobacter baumannii. Carbapenems are the principal agents used to treat A. baumannii infections. However, when strains develop resistance to this class of antibiotics, colistin is considered one of the last-resort drugs. However, the appearance of resistance to colistin also makes treatment of the Acinetobacter infections very difficult. Antimicrobial peptides (AMP) from the innate immunity hold promise as new alternative antibiotics due to their multiple biological properties. In this study, we characterized the activity and the membrane-perturbing mechanism of bactericidal action of a derivative of a frog-skin AMP, namely Esc(1-21), when used alone or in combination with colistin against multidrug-resistant A. baumannii clinical isolates. We found that the mixture of the two compounds had a synergistic effect in inhibiting the growth and killing of all of the tested strains. When combined at dosages below the minimal inhibitory concentration, the two drugs were also able to slow down the microbial growth and to potentiate the membrane-perturbing effect. To the best of our knowledge, this is the first report showing a synergistic effect between AMPs, i.e., Esc(1-21), and colistin against colistin-resistant A. baumannii clinical isolates, highlighting the potential clinical application of such combinational therapy.

show abstract

“…It was also found that two studied AMPs, alone and in combination with antibiotics, showed the ability to kill XDR A. baumannii and colistin-resistant P. aeruginosa isolates. Among the combination therapy of AMPs and antibiotics, synergism of Nisin + colistin and P10 + ceftazidime/doripenem shows considerable therapeutic worthiness as antibacterial drugs against colistin-resistant isolates (Jahangiri et al 2021 ). In another study, six cationic α-helical frog skin-derived AMPs including CPF-AM1, PGLa-AM1, B2RP-ERa, [E4K] alyteserin-1c, [D4K] B2RP, and [G4K] XT-7 against colistin-resistant Acinetobacter isolates were examined.…”

Section: Amp In the War With Colistin-resistant Bacteriamentioning

confidence: 99%

Rescuing humanity by antimicrobial peptides against colistin-resistant bacteria

Moghadam

Mojtahedi

Moghaddam

et al. 2022

Appl Microbiol Biotechnol

View full text Add to dashboard Cite

It has been about a century since the discovery of the first antibiotic, and during this period, several antibiotics were produced and marketed. The production of high-potency antibiotics against infections led to victories, but these victories were temporary. Overuse and misuse of antibiotics have continued to the point that humanity today is almost helpless in the fight against infection. Researchers have predicted that by the middle of the new century, there will be a dark period after the production of antibiotics that doctors will encounter antibiotic-resistant infections for which there is no cure. Accordingly, researchers are looking for new materials with antimicrobial properties that will strengthen their ammunition to fight antibiotic-resistant infections. One of the most important alternatives to antibiotics introduced in the last three decades is antimicrobial peptides (AMPs), which affect a wide range of microbes. Due to their different antimicrobial properties from antibiotics, AMPs can fight and kill MDR, XDR, and colistin-resistant bacteria through a variety of mechanisms. Therefore, in this study, we intend to use the latest studies to give a complete description of AMPs, the importance of colistin-resistant bacteria, and their resistance mechanisms, and represent impact of AMPs on colistin-resistant bacteria. Key points • AMPs as limited options to kill colistin-resistant bacteria. • Challenge of antibiotics resistance, colistin resistance, and mechanisms. • What is AMPs in the war with colistin-resistant bacteria?

show abstract

Synergistic effect of two antimicrobial peptides, Nisin and P10 with conventional antibiotics against extensively drug-resistant Acinetobacter baumannii and colistin-resistant Pseudomonas aeruginosa isolates

Cited by 56 publications

References 39 publications

Insect antimicrobial peptides: potential weapons to counteract the antibiotic resistance

Insect antimicrobial peptides: potential weapons to counteract the antibiotic resistance

The Antimicrobial Peptide Esc(1-21) Synergizes with Colistin in Inhibiting the Growth and in Killing Multidrug Resistant Acinetobacter baumannii Strains

Rescuing humanity by antimicrobial peptides against colistin-resistant bacteria

Contact Info

Product

Resources

About