Synergistic Effects of Anti-MRSA Herbal Extracts Combined with Antibiotics

Bao, Mei; Zhang, Lulu; Liu, Bin; Li, Li; Zhang, Yin; Zhao, Heru; Ji, Xinyu; Chen, Qing; Hu, Mingliang; Bai, Jingan; Pang, Guoming; Yi, Jianfeng; Tan, Yong; Lü, Cheng

doi:10.2217/fmb-2020-0001

Cited by 19 publications

(12 citation statements)

References 83 publications

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“…Введение тетрациклинов но- ЧАСТНАЯ ЗООТЕХНИЯ, КОРМЛЕНИЕ ЖИВОТНЫХ вого поколения в организм животных [15] также не оказывает негативного влияния на уровень эритроцитов, в то же время отмечено увеличение уровня гемоглобина в клетках. Подтверждения положительного синергетического действия антибиотиков и фитохимических веществ получены некоторыми исследователями: в отношении усиления антибактериального эффекта [16] на грамотрицательные микроорганизмы [17] при комбинации тетрациклина и неочищенных экстрактов растений (Vernoniaa mygdalina, Garciniak ola); Macleayac ordata улучшает действие тетрациклина на показатели роста цыплят-бройлеров, такие как выживаемость, суточный вес и соотношение корма к весу [18]. Схожий эффект был отмечен в нашем эксперименте.…”

Section: результаты и обсуждение / Results and Discussionunclassified

The effect of the combined use of gammaoctalactone and chlortetracycline in the broiler diet: live weight, feed efficiency and the microbiome of the caecum

et al. 2022

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Relevance, materials and methods. The experimental scheme included the control group — the main diet (MD); group I (positive control) — MD + chlortetracycline (20%) 0.63 g per 1 kg of body weight for 20 days; group II — MD + gamma-octalactone at a dosage of 0.1 ml/kg of b.w./day; III group — MD + gammaoctalactone + chlortetracycline (20%).Results. In the course of research, the advantage of the live weight of experimental broilers over the control was established. The broilers that received gamma-octolactone + chlortetracycline with the main dietwere distinguished by the greatest live weight (16.5% more than in the control) . A similar situation was observed in terms of live weight gains. Broilers of the experimental groups ate more feed (by 3.23–8.47%), against the background of low feed consumption per 1 kg of live weight (by 6.38–10.6%) compared to the control. Broilers from group III had a higher content of erythrocytes (by 12.6–30.7%) and the weight of the spleen. The microbial profile of group III broilers (a combination of gamma-octalactone and chlortetracycline) was represented by microorganisms belonging to 4 phylum. The dominant phylum was Firmicutes (81.3%). Comparison with the control showed that the combination of substances reduced the number of bacteria of this phylum by 4.46%, against the background of an increase in the number of representatives of the Bacteroidetes phylum by 9.32% relative to the control. There was an increase in representatives of the genera Alistipes, Lactobacillus and unclassified genera of the family Clostridiales, while the number of representatives of unclassified genera of the family Ruminococcaceae decreased.

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Section: результаты и обсуждение / Results and Discussionunclassified

The effect of the combined use of gammaoctalactone and chlortetracycline in the broiler diet: live weight, feed efficiency and the microbiome of the caecum

et al. 2022

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“…In summary, herbal extracts combined with antibiotics such as quinolones, β-lactams, aminoglycosides, tetracyclines, and glycopeptides could greatly enhance antibacterial effects, reduce therapeutic dose, reduce adverse effects, and reverse MRSA resistance. As a result, botanicals coupled with antibiotics could be a beneficial MRSA treatment strategy [82].…”

Section: Synergistic Effect Of Synthetic and Natural Drugs For Mrsa T...mentioning

confidence: 99%

Potential Use of African Botanicals and Other Compounds in the Treatment of Methicillin-Resistant Staphylococcus aureus Infections

Adesanya¹,

Ogunlakin²

2023

Infectious Diseases

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Infections caused by the group of Staphylococcus bacteria are commonly called Staph infections, and over 30 types of Staphylococcal bacteria exist with Staphylococcus aureus causing about 90% of the infections from the genus. Staphylococcus aureus (S. aureus) is a major cause of both hospital- and community-acquired infections with major concern arising from its strain of species that is resistant to many antibiotics. One of such strain is the Methicillin-resistant Staphylococcus aureus (MRSA) that has been described to be a resistance to methicillin drugs. Another is glycopeptides-resistant emerging from the increased use of glycopeptides drugs. This continuous emergence and spread of new resistant strains of S. aureus is a major challenge which makes the search for novel anti-resistant agents imperative. The development of vaccines from natural and synthetic products is some of the measures being proposed for the protection against the infections. Also, the development of monoclonal or polyclonal antibodies for passive immunization is sought for, and attentions with regard to arriving at successful trials have been directed back to medicinal plant research as an alternative. This review discusses the treatment strategies of MRSA, the antibacterial property of various medicinal plants, and the influence of their active compounds on methicillin-resistant S. aureus (MRSA), as well as to recommend the path to future research in this area.

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“…Methicillin-resistant S. aureus (MRSA) has severe multidrug resistance to aminoglycosides, 26 fluoroquinolones, 27 tetracycline, 28 macrolides, and other antimicrobial drugs. 29 , 30 Vancomycin-resistant Enterococcus (VRE) was first discovered in a clinical isolate in 1986. Vancomycin-resistant S. aureus (VRSA) isolates, which pose serious threat to healthcare, were discovered in 2002 because of the transmission of vanA resistance genes.…”

Section: Major Drug-resistant Bacteriamentioning

confidence: 99%

Development and Research Progress of Anti-Drug Resistant Bacteria Drugs

Cui¹,

Lü²,

Yue³

2021

IDR

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Bacterial resistance has become increasingly serious because of the widespread use and abuse of antibiotics. In particular, the emergence of multidrug-resistant bacteria has posed a serious threat to human public health and attracted the attention of the World Health Organization (WHO) and the governments of various countries. Therefore, the establishment of measures against bacterial resistance and the discovery of new antibacterial drugs are increasingly urgent to better contain the emergence of bacterial resistance and provide a reference for the development of new antibacterial drugs. In this review, we discuss some antibiotic drugs that have been approved for clinical use and a partial summary of the meaningful research results of anti-drug resistant bacterial drugs in different fields, including the antibiotic drugs approved by the FDA from 2015 to 2020, the potential drugs against drug-resistant bacteria, the new molecules synthesized by chemical modification, combination therapy, drug repurposing, immunotherapy and other therapies.

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Synergistic Effects of Anti-MRSA Herbal Extracts Combined with Antibiotics

Cited by 19 publications

References 83 publications

The effect of the combined use of gammaoctalactone and chlortetracycline in the broiler diet: live weight, feed efficiency and the microbiome of the caecum

The effect of the combined use of gammaoctalactone and chlortetracycline in the broiler diet: live weight, feed efficiency and the microbiome of the caecum

Potential Use of African Botanicals and Other Compounds in the Treatment of Methicillin-Resistant Staphylococcus aureus Infections

Development and Research Progress of Anti-Drug Resistant Bacteria Drugs

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