Synergistic effects of bisphosphonate and calcium phosphate nanoparticles on peri-implant bone responses in osteoporotic rats

Alghamdi, Hamdan S.; Bosco, Ruggero; Both, Sanne K.; Iafisco, Michele; Leeuwenburgh, Sander C. G.; Jansen, John A.; Beucken, Jeroen J.J.P. van den

doi:10.1016/j.biomaterials.2014.03.069

Cited by 75 publications

(72 citation statements)

References 41 publications

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“…Similar results were also observed with previous HA-based nanoparticles, supporting the bioactivity and osteoinductivity of HA nanoparticles. 10–12,14 Compared pure silk particles, higher expression of osteocalcin occurred the silk-HA composite particles without the loading of BMP-2 which suggested that the upregulation of osteocalcin should be due to the HA existence. The controlled release of BMP-2 could also improve the upregulatation of osteocalcin.…”

Section: Resultsmentioning

confidence: 99%

Bioactive natural protein–hydroxyapatite nanocarriers for optimizing osteogenic differentiation of mesenchymal stem cells

et al. 2016

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Improving the controlled release of bioactive growth factors to regulate cell behavior and tissue regeneration remains a need in tissue engineering and regenerative medicine. Inorganic and polymeric nanoparticles have been extensively fabricated as bioactive biomaterials with enhanced biocompatibility and effective carriers of therapeutic agents, however, challenges remain such as the achievement of high loading capacity and sustained release, and the bioactivity preservation of growth factors. Here, a multilayered, silk coated hydroxyapatite (HA) nanocarrier with drug loading-release capacity superior to pure silk or HA nanoparticles was developed. Bone morphogenetic protein-2 (BMP-2) was bound to the silk coatings with a high binding efficiency of 99.6%, significantly higher than that in silk or the HA nanoparticles alone. The release of BMP-2 was sustained in vitro over a period of 21 days without burst release. Compared with BMP-2 loaded silk or HA particles, bone mesenchymal stem cells (BMSCs) showed improved proliferation and osteogenesis when cultured with the BMP-2 loaded composite nanocarriers. Therefore, these silk-HA composite nanoparticles present a useful approach to designing bioactive nanocarrier systems with enhanced functions for bone tissue regeneration needs.

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Section: Resultsmentioning

confidence: 99%

Bioactive natural protein–hydroxyapatite nanocarriers for optimizing osteogenic differentiation of mesenchymal stem cells

et al. 2016

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“…Alternatively, recent experimental work has shown beneficial effects of ESD-based coatings, which makes that actual coating adhesion might not be necessary for anti-osteoporotic effects of loaded drugs onto an implant surface [42]. Other methods to incorporate bisphosphonate as a co-precipitation compound during the synthesis of calcium phosphate crystals could reduce the therapeutic effect of the bisphosphonate loaded onto bigger hydroxyapatite crystals A c c e p t e d M a n u s c r i p t obtained due to high temperature of synthesis (90 ºC) [28,43].…”

Section: Discussionmentioning

confidence: 97%

Hydroxyapatite nanocrystals functionalized with alendronate as bioactive components for bone implant coatings to decrease osteoclastic activity

Bosco

Iafisco

Tampieri

et al. 2015

Applied Surface Science

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“…The resulting nanoengineered surface showed multifunctional properties, such as antifouling, combined with antibacterial properties, thus reducing the adhesion and viability of gram-positive (Staphylococcus aureus) and gram-negative (Pseudomonas aeruginosa) bacteria, without apparent cytotoxicity (i.e., against African green monkey kidney fibroblast-like cells; COS-7). NE attachment is usually induced by noncovalent bonds, especially with electrostatic (i.e., +/-charge combination) and other interactions (e.g., hydrogen bonds, hydrophobic, hostguest chemistry; Marsich et al 2013;Alghamdi et al 2014;Borges et al 2014;Horev et al 2015;Jia et al 2016). In some cases, an NE-surface attachment through covalent bonds can provide more resilient assemblies for preventing deterioration and undesired detachment of NEs (Mokkaphan et al 2014).…”

Section: Nanoelementmentioning

confidence: 99%

Nanosized Building Blocks for Customizing Novel Antibiofilm Approaches

Paula

Koo

2016

J Dent Res

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Recent advances in nanotechnology provide unparalleled flexibility to control the composition, size, shape, surface chemistry, and functionality of materials. Currently available engineering approaches allow precise synthesis of nanocompounds (e.g., nanoparticles, nanostructures, nanocrystals) with both top-down and bottom-up design principles at the submicron level. In this context, these "nanoelements" (NEs) or "nanosized building blocks" can 1) generate new nanocomposites with antibiofilm properties or 2) be used to coat existing surfaces (e.g., teeth) and exogenously introduced surfaces (e.g., restorative or implant materials) for prevention of bacterial adhesion and biofilm formation. Furthermore, functionalized NEs 3) can be conceived as nanoparticles to carry and selectively release antimicrobial agents after attachment or within oral biofilms, resulting in their disruption. The latter mechanism includes "smart release" of agents when triggered by pathogenic microenvironments (e.g., acidic pH or low oxygen levels) for localized and controlled drug delivery to simultaneously kill bacteria and dismantle the biofilm matrix. Here we discuss inorganic, metallic, polymeric, and carbon-based NEs for their outstanding chemical flexibility, stability, and antibiofilm properties manifested when converted into bioactive materials, assembled on-site or delivered at biofilm-surface interfaces. Details are provided on the emerging concept of the rational design of NEs and recent technological breakthroughs for the development of a new generation of nanocoatings or functional nanoparticles for biofilm control in the oral cavity.

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Synergistic effects of bisphosphonate and calcium phosphate nanoparticles on peri-implant bone responses in osteoporotic rats

Cited by 75 publications

References 41 publications

Bioactive natural protein–hydroxyapatite nanocarriers for optimizing osteogenic differentiation of mesenchymal stem cells

Bioactive natural protein–hydroxyapatite nanocarriers for optimizing osteogenic differentiation of mesenchymal stem cells

Hydroxyapatite nanocrystals functionalized with alendronate as bioactive components for bone implant coatings to decrease osteoclastic activity

Nanosized Building Blocks for Customizing Novel Antibiofilm Approaches

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