Synergistic effects of carotenoids: Therapeutic benefits on human health

Islam, Fahadul; Khan, Jishan; Zehravi, Mehrukh; Das, Rajib; Haque, M. Akiful; Banu, Ahmedi; Parwaiz, Shaikh; Nainu, Firzan; Nafady, Mohamed H.; Shahriar, S. M. Shatil; Hossain, Md. Jamal; Muzammil, Khursheed; Emran, Talha Bin

doi:10.1016/j.procbio.2023.11.033

Cited by 5 publications

(5 citation statements)

References 157 publications

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“…Previous studies have demonstrated many excellent properties of sericin derived from commercial white cocoons, including antioxidant properties, antibacterial properties, UV protection, good water solubility, and moisture retention [29], as a biomaterial. A lot of research has also confirmed the potential health benefits of carotenoids for humans, such as anticancer, anti-inflammatory, antibacterial, antidiabetic, and neuroprotective [12]. For B. mori, in addition to white cocoons, there are also yellow-red cocoons produced by rare local strains.…”

Section: Discussionmentioning

confidence: 99%

“…Many composition materials have been developed to obtain better properties by means of synergistic effects among materials [33,34]. The more excellent properties of natural carotenoid-containing sericin obviously resulted from the synergistic effect of sericin with carotenoids, each of which also had commendable biocompatibility, inoxidizability, and antibacterial properties [12]. These results suggested that natural carotenoid-containing sericin derived from strains XS7 and XS8 is a natural hybrid material between sericin and carotenoids, rather than a simple mixture of sericin and carotenoids, and thus displays more excellent characteristics than white cocoon sericin and carotenoids.…”

Section: Discussionmentioning

confidence: 99%

“…Given the outstanding antimicrobial activity demonstrated by white sericin [27] and carotenoids [12], it is enticing to investigate whether XS7 and XS8 sericin exhibit stronger antimicrobial activity than Qiubai sericin. Through antibacterial experiments, Qiubai sericin manifested an inhibitory effect on E. coli at the concentration of 80 mg/mL or 40 mg/mL.…”

Section: Comparison Of Antimicrobial Effects Of Sericin From Xs7 Xs8 ...mentioning

confidence: 99%

“…Carotenoids usually contain eight isoprenoid units as their basic components, which endow carotenoids with good properties [11]. The potential health benefits of carotenoids have been well-established in many studies, for example anticancer, anti-inflammatory, antibacterial, antidiabetic, and neuroprotective [12]. Based on the physiological activity of carotenoids, they are embedded in drug carriers for medical research [13].…”

Section: Introductionmentioning

confidence: 99%

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The Potential of Natural Carotenoids-Containing Sericin of the Domestic Silkworm Bombyx mori

Liu,

Zhang,

Zhou

et al. 2024

IJMS

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Sericin derived from the white cocoon of Bombyx mori has been attracting more attention for its utilization in food, cosmetics, and biomedicine. The potential health benefits of natural carotenoids for humans have also been well-established. Some rare strains of Bombyx mori (B. mori) produce yellow–red cocoons, which endow a potential of natural carotenoid-containing sericin. We hypothesized that natural carotenoid-containing sericin from yellow–red cocoons would exhibit better properties compared with white cocoon sericin. To investigate the physicochemical attributes of natural carotenoid-containing sericin, we bred two silkworm strains from one common ancestor, namely XS7 and XS8, which exhibited different cocoon colors as a result of the inconsistent distribution of lutein and β-carotene. Compared with white cocoon sericin, the interaction between carotenoids and sericin molecules in carotenoid-containing sericin resulted in a unique fluorescence emission at 530, 564 nm. The incorporation of carotenoids enhanced the antibacterial effect, anti-cancer ability, cytocompatibility, and antioxidant of sericin, suggesting potential wide-ranging applications of natural carotenoid-containing sericin as a biomass material. We also found differences in fluorescence characteristics, antimicrobial effects, anti-cancer ability, and antioxidants between XS7 and XS8 sericin. Our work for the first time suggested a better application potential of natural carotenoid-containing sericin as a biomass material than frequently used white cocoon sericin.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Comparison Of Antimicrobial Effects Of Sericin From Xs7 Xs8 ...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Potential of Natural Carotenoids-Containing Sericin of the Domestic Silkworm Bombyx mori

Liu,

Zhang,

Zhou

et al. 2024

IJMS

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“…Some of these drugs or supplements currently available in international markets include Pregvit ® , Soriatane ® , and Epuris ® , which are indicated for reducing photosensitivity in patients, treating psoriasis, and managing severe recalcitrant nodular acne, respectively [ 19 ]. Due to their clinical safety and tolerability, carotenoids have been suggested as important adjuvant drugs in the treatment of COVID-19 [ 20 ], melanoma [ 21 ], breast cancer [ 22 ], diabetic retinopathy [ 23 ], and MetS [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in the Therapeutic Potential of Carotenoids in Preventing and Managing Metabolic Disorders

Ortega-Regules,

Martínez-Thomas,

Schürenkämper-Carrillo

et al. 2024

Plants

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Carotenoids constitute compounds of significant biological interest due to their multiple biological activities, such as antimicrobial, anticancer, antiadipogenic, antidiabetic, and antioxidant properties. Metabolic syndrome (MetS) comprehends a series of metabolic abnormalities (e.g., hypertension, obesity, and atherogenic dyslipidemia) that can affect children, adolescents, and the elderly. The treatment of MetS involves numerous medications, which, despite their efficacy, pose challenges due to prolonged use, high costs, and various side effects. Carotenoids and their derivatives have been proposed as alternative treatments to MetS because they reduce serum triglyceride concentrations, promote insulin response, inhibit adipogenesis, and downregulate angiotensin-converting enzyme activity. However, carotenoids are notably sensitive to pH, light exposure, and temperature. This review addresses the activity of carotenoids such as lycopene, lutein, fucoxanthin, astaxanthin, crocin, and β-carotene towards MetS. It includes a discussion of sources, extraction methods, and characterization techniques for analyzing carotenoids. Encapsulation approaches are critically reviewed as alternatives to prevent degradation and improve the biological performance of carotenoids. A brief overview of the physiopathology and epidemiology of the diseases, including MetS, is also provided.

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