Synergistic effects of CuO/TiO<sub>2</sub>‐chitosan‐farnesol nanocomposites: Synthesis, characterization, antimicrobial, and anticancer activities on melanoma cells SK‐MEL‐3

Indumathi, Thangavelu; Suriyaprakash, Jagadeesh; Alarfaj, Abdullah A.; Hirad, Abdurahman Hajinur; Jaganathan, Ravindran; Mathanmohun, Maghimaa

doi:10.1002/jobm.202300505

Cited by 12 publications

(1 citation statement)

References 51 publications

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“…Biomedicine is crucial for advancing nanotechnology, particularly in developing and using nanomaterials for various medical purposes. 4 Key contributions include drug delivery, imaging, diagnostics, tissue engineering, therapeutics, biosensing, and safety assessment. Collaborations between biomedicine and nanotechnology are driving revolutionary healthcare improvements, evident in the widespread use of nanoparticles (NPs) in biological applications.…”

Section: Introductionmentioning

confidence: 99%

Biocidal activities of nickel oxide nanoparticles modified by copper and manganese, synthesized by green process

Ganapathy,

Pandey,

Bishnoi

et al. 2024

Applied Organom Chemis

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In recent years, the development of dual dopant‐based nanoparticles (NPs) has gained significant attention as they possess exceptional physico‐chemical and biomedical properties, making them potential candidates for antimicrobial and anticancer uses. In this research, we successfully synthesized nickel oxide (NiO) and copper, manganese‐doped NiO (CuMn:NiO) NPs using a green synthesis method. The synthesis process involved Trigonella foenum‐graecum (T.f.graecum) leaves extract as a nucleating agent. The synthesized nanoparticles were confirmed by various physico‐chemical studies. Based on X‐ray diffraction analysis, the median size was determined as 36 nm for NiO and 32 nm for CuMn:NiO NPs. The antibacterial study revealed that CuMn:NiO NPs exhibited a higher zone of inhibition in contrast to both Gram‐positive (Streptococcus pneumoniae, Bacillus subtilis, Bacillus megaterium) and Gram‐negative bacteria (Klebsiella pneumoniae, Escherichia coli, Vibrio cholerae) compared with NiO NPs and commercial amoxicillin. The antifungal studies conducted against Candida albicans demonstrated that CuMn:NiO NPs exhibited enhanced efficacy in comparison to NiO NPs. In vitro testing against human breast cancer cells (MCF‐7) demonstrated the anticancer potential of NiO and CuMn:NiO NPs, supported by IC50 concentrations of 11 and 9 μg/mL, respectively. The photoluminescence (PL) spectra of NiO and CuMn:NiO NPs exhibited a green emission at 508 and 518 nm, respectively, which indicated the generation of active free radicals by the NPs. These findings suggest that CuMn:NiO NPs hold promise in the healthcare industry.

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Section: Introductionmentioning

confidence: 99%

Biocidal activities of nickel oxide nanoparticles modified by copper and manganese, synthesized by green process

Ganapathy,

Pandey,

Bishnoi

et al. 2024

Applied Organom Chemis

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Pemetrexed loaded gold nanoparticles as cytotoxic and apoptosis inducers in lung cancer cells through ROS generation and mitochondrial dysfunction pathway

Periasamy,

Alarfaj

et al. 2024

Biotech and App Biochem

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Supramolecular nanoparticles containing peptides and drugs have recently gained recognition as an effective tumor treatment drug delivery system. A multitarget drug termed pemetrexed is effective against various cancers, including nonsmall cell lung cancer. The work aims to establish the capability of pemetrexed gold nanoparticles (PEM‐AuNPs) to induce apoptosis and explore molecular changes. X‐ray diffraction, Fourier‐transform infrared spectroscopy, ultraviolet–visible spectroscopy, scanning electron microscope, and transmission electron microscope were used to investigate the synthesized nanoparticles. The MTT assay was utilized to investigate the anticancer properties of PEM‐AuNPs at varying concentrations (50, 100, and 200 µM). PEM‐AuNPs demonstrated a decrease in cell viability with 55.87%, 43.04%, and 25.59% for A549 cells and 54.31%, 37.40%, and 25.84% for H1299 cells at the respective concentrations. To assess apoptosis and perform morphological analysis, diverse biochemical staining techniques, including acridine orange‐ethidium bromide and 4′,6‐diamidino‐2‐phenylindole nuclear staining assays, were employed. Additionally, 2′,7′‐dichlorofluorescein diacetate staining confirmed the induction of reactive oxygen species generation, while JC‐1 staining validated the impact on the mitochondrial membrane at the IC50 concentration of PEM‐AuNPs. Thus, the study demonstrated that the synthesized PEM‐AuNPs exhibited enhanced anticancer activity against both A549 and H1299 cells.

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Facile construction of gefitinib‐loaded zeolitic imidazolate framework nanocomposites for the treatment of different lung cancer cells

Aiyasamy,

Ramasamy,

Hirad

et al. 2024

Biotech and App Biochem

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Gefitinib (GET) is a revolutionary targeted treatment inhibiting the epidermal growth factor receptor's tyrosine kinase action by competitively inhibiting the ATP binding site. In preclinical trials, several lung cancer cell lines and xenografts have demonstrated potential activity with GET. Response rates neared 25% in preclinical trials for non‐small cell lung cancer. Here, we describe the one‐pot synthesis of GET@ZIF‐8 nanocomposites (NCs) in pure water, encapsulating zeolitic imidazolate framework 8 (ZIF‐8). This method developed NCs with consistent morphology and a loading efficiency of 9%, resulting in a loading capacity of 20 wt%. Cell proliferation assay assessed the anticancer effect of GET@ZIF‐8 NCs on A549 and H1299 cells. The different biochemical staining (Calcein‐AM and PI and 4′,6‐Diamidino‐2‐phenylindole nuclear staining) assays assessed the cell death and morphological examination. Additionally, the mode of apoptosis was evaluated by mitochondrial membrane potential (∆ψm) and reactive oxygen species. Therefore, the study concludes that GET@ZIF‐8 NCs are pledged to treat lung cancer cells.

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Synergistic effects of CuO/TiO₂‐chitosan‐farnesol nanocomposites: Synthesis, characterization, antimicrobial, and anticancer activities on melanoma cells SK‐MEL‐3

Cited by 12 publications

References 51 publications

Biocidal activities of nickel oxide nanoparticles modified by copper and manganese, synthesized by green process

Biocidal activities of nickel oxide nanoparticles modified by copper and manganese, synthesized by green process

Pemetrexed loaded gold nanoparticles as cytotoxic and apoptosis inducers in lung cancer cells through ROS generation and mitochondrial dysfunction pathway

Facile construction of gefitinib‐loaded zeolitic imidazolate framework nanocomposites for the treatment of different lung cancer cells

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Synergistic effects of CuO/TiO2‐chitosan‐farnesol nanocomposites: Synthesis, characterization, antimicrobial, and anticancer activities on melanoma cells SK‐MEL‐3

Cited by 12 publications

References 51 publications

Biocidal activities of nickel oxide nanoparticles modified by copper and manganese, synthesized by green process

Biocidal activities of nickel oxide nanoparticles modified by copper and manganese, synthesized by green process

Pemetrexed loaded gold nanoparticles as cytotoxic and apoptosis inducers in lung cancer cells through ROS generation and mitochondrial dysfunction pathway

Facile construction of gefitinib‐loaded zeolitic imidazolate framework nanocomposites for the treatment of different lung cancer cells

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Synergistic effects of CuO/TiO₂‐chitosan‐farnesol nanocomposites: Synthesis, characterization, antimicrobial, and anticancer activities on melanoma cells SK‐MEL‐3