Synergistic effects of curcumin and its analogs with other bioactive compounds: A comprehensive review

Hosseini‐Zare, Maryam Sadat; Sarhadi, Mozhgan; Mehdi, Zarei; Thilagavathi, Ramasamy; Selvam, Chelliah

doi:10.1016/j.ejmech.2020.113072

Cited by 66 publications

(48 citation statements)

References 120 publications

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“…At the same time, it turned out that one of the mechanisms of anticancer activity that polyphenols, including curcumin, can influence is the excessive production of oxygen free radicals [ 34 ]. Curcumin is characterized by low bioavailability [ 36 ], therefore, in recent years, there has been a trend of looking for a method of delivering this compound in systems with various forms of drug carriers, e.g., liposomes, to increase systemic application possibility. In vitro studies showed that liposomal curcumin had a dose-dependent effect on LoVo cell viability in the MTT assay and increased cell number in apoptosis [ 36 , 37 ].…”

Section: Resultsmentioning

confidence: 99%

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Colorectal Adenocarcinoma Cell Culture in a Microfluidically Controlled Environment with a Static Molecular Gradient of Polyphenol

2021

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To study the simultaneous effect of the molecular gradient of polyphenols (curcumin, trans-resveratrol, and wogonin) and biological factors released from tumor cells on apoptosis of adjacent cells, a novel microfluidic system was designed and manufactured. The small height/volume of microfluidic culture chambers and static conditions allowed for establishing the local microenvironment and maintaining undisturbed concentration profiles of naturally secreted from cells biochemical factors. In all trials, we observe that these conditions significantly affect cell viability by stimulating cell apoptosis at lower concentrations of polyphenols than in traditional multiwell cultures. The observed difference varied between 20.4–87.8% for curcumin, 11.0–37.5% for resveratrol, and 21.7–62.2% for wogonin. At low concentrations of polyphenols, the proapoptotic substances released from adjacent cells, like protein degradation products, significantly influence cell viability. The mean increase in cell mortality was 38.3% for microfluidic cultures. Our research has also confirmed that the gradient microsystem is useful in routine laboratory tests in the same way as a multiwell plate and may be treated as its replacement in the future. We elaborated the new repetitive procedures for cell culture and tests in static gradient conditions, which may become a gold standard of new drug investigations in the future.

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Section: Resultsmentioning

confidence: 99%

“…Moreover, curcumin stops the cell cycle in the S phase of LoVo cells. It has also been shown that curcumin activates AMP-activated 5 protein kinase (AMPK) and suppresses NF p65 phosphorylation-κB, uPA and MMP9 [ 36 , 40 , 41 ].…”

Section: Resultsmentioning

confidence: 99%

Colorectal Adenocarcinoma Cell Culture in a Microfluidically Controlled Environment with a Static Molecular Gradient of Polyphenol

2021

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“…This effect could be explained by the synergetic effects of these two phenolic compounds on enhancing plant metabolic response to cope with abiotic stresses. Indeed, some authors reported the synergistic effects among phenolic compounds on biological activity improvement, including antioxidant and enzyme inhibition effects [ 31 , 32 , 33 , 34 , 35 ]. In stressed conditions, CGA and HES application combined improved the enzyme inhibition effects compared with the salt group (except for BChE).…”

Section: Discussionmentioning

confidence: 99%

The Combination of Mild Salinity Conditions and Exogenously Applied Phenolics Modulates Functional Traits in Lettuce

Zhang

Martinelli

Senizza

et al. 2021

Plants

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The quest for sustainable strategies aimed at increasing the bioactive properties of plant-based foods has grown quickly. In this work, we investigated the impact of exogenously applied phenolics, i.e., chlorogenic acid (CGA), hesperidin (HES), and their combinations (HES + CGA), on Lactuca sativa L. grown under normal- and mild-salinity conditions. To this aim, the phenolic profile, antioxidant properties, and enzyme inhibitory activity were determined. The untargeted metabolomics profiling revealed that lettuce treated with CGA under non-stressed conditions exhibited the highest total phenolic content (35.98 mg Eq./g). Lettuce samples grown under salt stress showed lower phenolic contents, except for lettuce treated with HES or HES + CGA, when comparing the same treatment between the two conditions. Furthermore, the antioxidant capacity was investigated through DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,20-azinobis-(3-ethylbenzothiazoline-6-sulfonate)), and FRAP (ferric reducing antioxidant power) assays, coupled with metal-chelating activity and phosphomolybdenum capacity. An exciting increase in radical scavenging capacity was observed in lettuce treated with exogenous phenolics, in both stress and non-stress conditions. The inhibitory activity of the samples was evaluated against target health-related enzymes, namely cholinesterases (acetylcholinesterase; AChE; butyryl cholinesterase; BChE), tyrosinase, α-amylase, and α-glucosidase. Lettuce treated with HES + CGA under non-stress conditions exhibited the strongest inhibition against AChE and BChE, while the same treatment under salinity conditions resulted in the highest inhibition capacity against α-amylase. Additionally, CGA under non-stress conditions exhibited the best inhibitory effect against tyrosinase. All the functional traits investigated were significantly modulated by exogenous phenolics, salinity, and their combination. In more detail, flavonoids, lignans, and stilbenes were the most affected phenolics, whereas glycosidase enzymes and tyrosinase activity were the most affected among enzyme assays. In conclusion, the exogenous application of phenolics to lettuce represents an effective and green strategy to effectively modulate the phenolic profile, antioxidant activity, and enzyme inhibitory effects in lettuce, deserving future application to produce functional plant-based foods in a sustainable way.

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“…Cur also exhibits an antitumor effect as an inhibitor of the transcription factor signal transducer and activator of transcription 3 (STAT3) in various tumors [ 18 , 19 , 20 , 21 ], and STAT3 is reported to upregulate the expression of NNMT in CRC [ 22 ]. In addition, it has been reported that Cur potentiates the effect of many chemotherapy drugs, including 5-FU [ 18 , 23 , 24 ]. It has been observed that, regardless of the drug that it is combined with, Cur always results in an enhanced effect with reduced dose and side effects [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, it has been reported that Cur potentiates the effect of many chemotherapy drugs, including 5-FU [ 18 , 23 , 24 ]. It has been observed that, regardless of the drug that it is combined with, Cur always results in an enhanced effect with reduced dose and side effects [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Curcumin Reverses NNMT-Induced 5-Fluorouracil Resistance via Increasing ROS and Cell Cycle Arrest in Colorectal Cancer Cells

Fang

Shao

et al. 2021

Biomolecules

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Nicotinamide N-methyltransferase (NNMT) plays multiple roles in improving the aggressiveness of colorectal cancer (CRC) and enhancing resistance to 5-Fluorouracil (5-FU), making it an attractive therapeutic target. Curcumin (Cur) is a promising natural compound, exhibiting multiple antitumor effects and potentiating the effect of 5-FU. The aim of the present study is to explore the effect of Cur on attenuating NNMT-induced resistance to 5-FU in CRC. A panel of CRC cell lines with different NNMT expressions are used to characterize the effect of Cur. Herein, it is observed that Cur can depress the expression of NNMT and p-STAT3 in CRC cells. Furthermore, Cur can induce inhibition of cell proliferation, G2/M phase cell cycle arrest, and reactive oxygen species (ROS) generation, especially in high-NNMT-expression CRC cell lines. Cur can also re-sensitize high-NNMT-expression CRC cells to 5-FU both in vitro and in vivo. In summary, it is proposed that Cur can reverse NNMT-induced cell proliferation and 5-FU resistance through ROS generation and cell cycle arrest. Given that Cur has long been used, we suppose that Cur is a promising anticancer drug candidate with minimal side effects for human CRC therapy and can attenuate NNMT-induced resistance to 5-FU.

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Synergistic effects of curcumin and its analogs with other bioactive compounds: A comprehensive review

Cited by 66 publications

References 120 publications

Colorectal Adenocarcinoma Cell Culture in a Microfluidically Controlled Environment with a Static Molecular Gradient of Polyphenol

Colorectal Adenocarcinoma Cell Culture in a Microfluidically Controlled Environment with a Static Molecular Gradient of Polyphenol

The Combination of Mild Salinity Conditions and Exogenously Applied Phenolics Modulates Functional Traits in Lettuce

Curcumin Reverses NNMT-Induced 5-Fluorouracil Resistance via Increasing ROS and Cell Cycle Arrest in Colorectal Cancer Cells

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