Synergistic effects of hyperthermia in preoperative radiochemotherapy for rectal carcinoma

Furuta, Kazuhiro; Konishi, Fumio; Kanazawa, Kyotaro; Saito, Ken; Sugawara, Tadashi

doi:10.1007/bf02050814

Cited by 14 publications

(7 citation statements)

References 33 publications

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“…17 Grade 1 was defined as slight changes only; grade 2 as necrosis and degeneration in less than one-third of the tumor tissue; grade 3 as necrosis and degeneration in one-third to two-thirds of the tumor tissue; and grade 4 as necrosis and degeneration in more than two-thirds of the tumor tissue.…”

Section: Methodsmentioning

confidence: 99%

“…The details of our preoperative treatment regimen have been described in a previous report. 17 In brief, radiation treatment was carried out using a linear accelerator delivering 10 MV X-ray with two opposing fields by accelerated hyperfractionation. A dosage of 1.5 Gy was given twice a day for 5 days a week, to a total dose of 40.5 Gy.…”

Section: Methodsmentioning

confidence: 99%

“…To reduce the period required for preoperative treatment and also to enhance the tumoricidal effects of radiotherapy with less untoward side effects, we combined radiation therapy at a dose of 40.5 Gy, accelerated hyperfractionation, and chemotherapy using a 5-fluorouracil suppository, either with or without hyperthermia. 17 Herein, we report the favorable outcome of patients who underwent surgery following radiochemotherapy, and describe the associated complications after treatment.…”

Section: Introductionmentioning

confidence: 98%

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Improved outcome following preoperative radiochemotherapy: 40.5 Gy accelerated hyperfractionation and 5-fluorouracil suppositories for patients with carcinoma of the lower rectum

et al. 1999

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The aim of this study was to determine the long-term effects of administering preoperative radiochemotherapy to patients with carcinoma of the lower rectum. The outcomes of 29 patients who underwent curative surgery for carcinoma of the lower rectum after receiving radiochemotherapy in the form of 40.5 Gy accelerated hyperfractionation and a total dose of 3 400 mg 5-fluorouracil given as suppositories, with or without hyperthermia, and 48 patients who underwent surgery alone, were retrospectively compared. The tumors in all the patients were histologically diagnosed as stage T3. The cumulative 5-year survival rate and 5-year local recurrence-free rate of the patients treated with radiochemotherapy plus surgery were significantly better than those of the patients treated by surgery alone, the respective values being 80.5% vs 59.8% (P = 0.0325) and 95.7% vs 61.4% (P = 0.0041). Dehiscence of the perineal wound, anastomotic leakage, and postoperative ileus occurred at similar frequencies in both groups; however, perineal wound healing after abdominoperineal resection was delayed in the patients treated with radiochemotherapy plus surgery at 42.7 days vs 25.4 days (P = 0. 0062). In conclusion, although the wound healing was delayed, preoperative radiochemotherapy is considered to be beneficial for patients with carcinoma of the lower rectum.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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Improved outcome following preoperative radiochemotherapy: 40.5 Gy accelerated hyperfractionation and 5-fluorouracil suppositories for patients with carcinoma of the lower rectum

et al. 1999

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“…Before publication of the 'Dutch Deep Hyperthermia' trial, it had already been demonstrated in a number of phase I/II trials that adjunctive hyperthermia does not relevantly enhance the acute toxicity of radio-+/-chemotherapy in patients with primary and locally recurrent rectal cancer, while hyperthermic radio-/radiochemotherapy induced promising response rates. In addition, a clear-cut correlation between thermal dose applied and local tumour control was established in a mixed cohort of patients with both primary and recurrent rectal cancer in a report of our group [47][48][49][50][51][52]. Two randomised trials are available in which hyperthermia was added to standard radio-/radiochemotherapy in patients with primary rectal cancer.…”

Section: Regional Pelvic Hyperthermia In Locally Recurrent Rectal Cancermentioning

confidence: 99%

Treatment of Locally Recurrent Rectal Cancer with Special Focus on Regional Pelvic Hyperthermia

Hildebrandt

Wust²,

Gellermann³

et al. 2004

Oncol Res Treat

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Progress in surgery and adjuvant therapy has markedly improved local control and survival rates in patients with primary, non-metastatic rectal cancer. However, the prognosis of patients with locally recurrent disease is still poor, and a realistic chance for repeated treatment with curative intent is still restricted to the minority of cases. Therefore, effective palliation of symptoms and preservation of a good quality of life are the major goals of therapy for most patients with local recurrence of rectal cancer. Here we give a short overview on the options available for the treatment of pelvic recurrence of rectal cancer, with special focus on adjunctive regional pelvic radiofrequency hyperthermia.

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“…Since its first description in 1952, cutaneous MC has been reported to occur on the head [5, 7, 15, 23], neck [6], extremities [11, 13, 17]intertriginous areas [20]and the trunk [1]. MCs may also develop in the gastrointestinal tract [6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28], breast [29], lung, ovary and prostate. Therefore MC of the skin has to be differentiated from metastatic lesions [13, 25]of extracutaneous MC.…”

Section: Introductionmentioning

confidence: 99%

Primary Mucinous Carcinoma of the Scalp

Breier

Clabian²,

Pokieser³

et al. 2000

Dermatology

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Primary cutaneous mucinous carcinoma (MC) is a rare epithelial neoplasm derived from the sweat glands. Herein, we report a case of MC located on the head. A 66-year-old woman underwent excision of a nodular tumor with a reddish brown surface on the left parietal region. Histopathology revealed a neoplasm extending from the reticular dermis into the subcutaneous fat. The tumor cell aggregates showed cribriform and solid lobules and were embedded in lakes of mucin, separated by thin, fibrous septae. Focally single neoplastic cells were arranged in an Indian-file pattern. The tumor cells displayed an eosinophilic cytoplasm, large basophilic nuclei and some discrete nuclear atypia. Vascular spaces, filled by densely packed erythrocytes between the septae, were also observed. We compared the mucinous component with the tumor cell and the stromal component by light microscopy. Analyzing the tumor by an image analysis system in Alcian-blue-stained serial sections, we found the averaged total tumor area measuring 99.7 mm². The area of the mucinous component measured 92.4 mm², that of the tumor cells 3.7 mm² and that of the stromal component 3.6 mm². The extensive checkup of the patient disclosed no evidence for a further malignant neoplasm. After excision of the tumor an adjuvant radiotherapy was performed. The patient was free of recurrence and metastatic spread of the mucinous carcinoma during a 4-year follow-up.

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Synergistic effects of hyperthermia in preoperative radiochemotherapy for rectal carcinoma

Abstract: Addition of hyperthermia resulted in a greater degree of tumor necrosis and was considered to be useful as a preoperative treatment for rectal carcinoma.

Cited by 14 publications

References 33 publications

Improved outcome following preoperative radiochemotherapy: 40.5 Gy accelerated hyperfractionation and 5-fluorouracil suppositories for patients with carcinoma of the lower rectum

Improved outcome following preoperative radiochemotherapy: 40.5 Gy accelerated hyperfractionation and 5-fluorouracil suppositories for patients with carcinoma of the lower rectum

Treatment of Locally Recurrent Rectal Cancer with Special Focus on Regional Pelvic Hyperthermia

Primary Mucinous Carcinoma of the Scalp

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