Synergistic effects of Isatis tinctoria L. and tacrolimus in the prevention of acute heart rejection in mice

Botanical Drugs, Synergy, and Network Pharmacology: Forth and Back to Intelligent Mixtures

“…This is an outstanding example of pharmacological synergy between two classes of compounds that target different proteins. There are many other recent reports on actual and putative pharmacological synergies between plant mixtures and/or single phytochemicals [68][69][70][71][72][73][74][75][76][77][78][79][80][81][82][83], but in many cases the experimental proof and in particular the clinical corroboration remain insufficient. Rational drug combinations are known in the clinic and have first been pointed out by Berenbaum in the 1980s [84].…”

Ginsenosides are active ingredients in Panax ginseng with immunomodulatory properties from cellular to organismal levels

“…CK, a potent immunosuppressive adjuvant, was tested by Wang et al. [ 86 ] for its ability to inhibit acute rejection in both C57BL/6 and BALB/c mice. The results showed that CK decreased the proliferation of lymphocytes.…”

New insights into immunomodulatory properties of lactic acid bacteria fermented herbal medicines

“…Ginsenoside Rh 2 can enhance the infiltration and cytotoxicity of T lymphocytes in tumors, improving the cellular immune function of tumor-bearing mice ( Wang et al, 2017 ). Ginsenoside compound K (CK) can inhibit the abnormal activation of T lymphocytes in mice with collagenous arthritis, and suppress memory T cells, preventing the immune system from rejecting heart transplantations ( Wang et al, 2009 ; Liu et al, 2014 ).…”